Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Jerod S Denton"'
Publikováno v:
eLife, Vol 12 (2023)
Volume-regulated anion channels (VRACs) mediate volume regulatory Cl- and organic solute efflux from vertebrate cells. VRACs are heteromeric assemblies of LRRC8A-E proteins with unknown stoichiometries. Homomeric LRRC8A and LRRC8D channels have a sma
Externí odkaz:
https://doaj.org/article/aa7ea42837e04d9ba238be46ae7f3f71
Autor:
Conor McCloskey, Cara Rada, Elizabeth Bailey, Samantha McCavera, Hugo A van den Berg, Jolene Atia, David A Rand, Anatoly Shmygol, Yi‐Wah Chan, Siobhan Quenby, Jan J Brosens, Manu Vatish, Jie Zhang, Jerod S Denton, Michael J Taggart, Catherine Kettleborough, David Tickle, Jeff Jerman, Paul Wright, Timothy Dale, Srinivasan Kanumilli, Derek J Trezise, Steve Thornton, Pamela Brown, Roberto Catalano, Nan Lin, Sarah K England, Andrew M Blanks
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 9, Pp 1161-1174 (2014)
Abstract Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including preterm birth, dysfunctional labour and post‐partum haemorrhage. Uterine contractile patterns are controlled by the generation of complex elec
Externí odkaz:
https://doaj.org/article/71bb4ab0b03e42c5af65876d7a37e163
Autor:
Jennifer L Herington, Daniel R Swale, Naoko Brown, Elaine L Shelton, Hyehun Choi, Charles H Williams, Charles C Hong, Bibhash C Paria, Jerod S Denton, Jeff Reese
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143243 (2015)
The uterine myometrium (UT-myo) is a therapeutic target for preterm labor, labor induction, and postpartum hemorrhage. Stimulation of intracellular Ca2+-release in UT-myo cells by oxytocin is a final pathway controlling myometrial contractions. The g
Externí odkaz:
https://doaj.org/article/f0f2083e05c54991a5f8cc8c6e99d788
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100700 (2014)
Mosquitoes are important disease vectors that transmit a wide variety of pathogens to humans, including those that cause malaria and dengue fever. Insecticides have traditionally been deployed to control populations of disease-causing mosquitoes, but
Externí odkaz:
https://doaj.org/article/fbcdfa1e9b0e48e481ae0f11a9325307
Autor:
Rene Raphemot, Matthew F Rouhier, Daniel R Swale, Emily Days, C David Weaver, Kimberly M Lovell, Leah C Konkel, Darren W Engers, Sean R Bollinger, Corey Hopkins, Peter M Piermarini, Jerod S Denton
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e110772 (2014)
Vector-borne diseases such as dengue fever and malaria, which are transmitted by infected female mosquitoes, affect nearly half of the world's population. The emergence of insecticide-resistant mosquito populations is reducing the effectiveness of co
Externí odkaz:
https://doaj.org/article/e02339d3e86b4ec08682a15b3ac994af
Autor:
Rene Raphemot, Matthew F Rouhier, Corey R Hopkins, Rocco D Gogliotti, Kimberly M Lovell, Rebecca M Hine, Dhairyasheel Ghosalkar, Anthony Longo, Klaus W Beyenbach, Jerod S Denton, Peter M Piermarini
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64905 (2013)
Mosquito-borne diseases such as malaria and dengue fever take a large toll on global health. The primary chemical agents used for controlling mosquitoes are insecticides that target the nervous system. However, the emergence of resistance in mosquito
Externí odkaz:
https://doaj.org/article/97eadc8a5b0a43be83b56b9f91e89b74
Autor:
Jerod S Denton
Publikováno v:
Frontiers in Pharmacology, Vol 2 (2011)
The inward rectifier family of potassium (Kir) channels is comprised of at least 16 family members exhibiting broad and often overlapping cellular, tissue or organ distributions. The discovery of disease-causing mutations in humans and experiments on
Externí odkaz:
https://doaj.org/article/30427501ae2e4daeaab9cf9e7c4de869
Autor:
Eric E. Figueroa, Jerod S. Denton
Publikováno v:
Channels, Vol 16, Iss 1, Pp 27-36 (2022)
Newly emerging roles of LRRC8 volume-regulated anion channels (VRAC) raise important questions about the therapeutic potential of VRAC in the treatment of epilepsy, type 2 diabetes, and other human diseases. A critical barrier to evaluating whether V
Externí odkaz:
https://doaj.org/article/1309af476b9141f4a355509a3ed9d3ba
Autor:
Karolina E. Zaborska, Prasanna K. Dadi, Matthew T. Dickerson, Arya Y. Nakhe, Ariel S. Thorson, Charles M. Schaub, Sarah M. Graff, Jade E. Stanley, Roy S. Kondapavuluru, Jerod S. Denton, David A. Jacobson
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101056- (2020)
Objective: Elevations in pancreatic α-cell intracellular Ca2+ ([Ca2+]i) lead to glucagon (GCG) secretion. Although glucose inhibits GCG secretion, how lactate and pyruvate control α-cell Ca2+ handling is unknown. Lactate enters cells through monoca
Externí odkaz:
https://doaj.org/article/739b7a2b2b794efa9353527289b42407
Autor:
Jerod S. Denton, Eric Delpire
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C603-C605
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d639e614ebf383fb7f4d62157a5198a
https://doi.org/10.1152/ajpcell.00457.2022
https://doi.org/10.1152/ajpcell.00457.2022