Zobrazeno 1 - 10
of 386
pro vyhledávání: '"Jerod S"'
Autor:
Yahua Zhang, Fabian Bock, Mohammed Ferdaus, Juan Pablo Arroyo, Kristie L Rose, Purvi Patel, Jerod S. Denton, Eric Delpire, Alan M. Weinstein, Ming-Zhi Zhang, Raymond C. Harris, Andrew S. Terker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The renal epithelium is sensitive to changes in blood potassium (K+). We identify the basolateral K+ channel, Kir4.2, as a mediator of the proximal tubule response to K+ deficiency. Mice lacking Kir4.2 have a compensated baseline phenotype w
Externí odkaz:
https://doaj.org/article/466eefddbfcf433986c90e461a6b9ab4
Autor:
Eric E. Figueroa, Jerod S. Denton
Publikováno v:
Channels, Vol 16, Iss 1, Pp 27-36 (2022)
Newly emerging roles of LRRC8 volume-regulated anion channels (VRAC) raise important questions about the therapeutic potential of VRAC in the treatment of epilepsy, type 2 diabetes, and other human diseases. A critical barrier to evaluating whether V
Externí odkaz:
https://doaj.org/article/1309af476b9141f4a355509a3ed9d3ba
Publikováno v:
eLife, Vol 12 (2023)
Volume-regulated anion channels (VRACs) mediate volume regulatory Cl- and organic solute efflux from vertebrate cells. VRACs are heteromeric assemblies of LRRC8A-E proteins with unknown stoichiometries. Homomeric LRRC8A and LRRC8D channels have a sma
Externí odkaz:
https://doaj.org/article/aa7ea42837e04d9ba238be46ae7f3f71
Autor:
Karolina E. Zaborska, Prasanna K. Dadi, Matthew T. Dickerson, Arya Y. Nakhe, Ariel S. Thorson, Charles M. Schaub, Sarah M. Graff, Jade E. Stanley, Roy S. Kondapavuluru, Jerod S. Denton, David A. Jacobson
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101056- (2020)
Objective: Elevations in pancreatic α-cell intracellular Ca2+ ([Ca2+]i) lead to glucagon (GCG) secretion. Although glucose inhibits GCG secretion, how lactate and pyruvate control α-cell Ca2+ handling is unknown. Lactate enters cells through monoca
Externí odkaz:
https://doaj.org/article/739b7a2b2b794efa9353527289b42407
Autor:
Aqeela Afzal, Eric E. Figueroa, Sujay V. Kharade, Kevin Bittman, Brittany K. Matlock, David K. Flaherty, Jerod S. Denton
Publikováno v:
Physiological Reports, Vol 7, Iss 23, Pp n/a-n/a (2019)
Abstract There has been a resurgence of interest in the volume‐regulated anion channel (VRAC) since the recent cloning of the LRRC8A‐E gene family that encodes VRAC. The channel is a heteromer comprised of LRRC8A and at least one other family mem
Externí odkaz:
https://doaj.org/article/1ed9b19f0c6b4c8cb960f91917af1c42
Autor:
Conor McCloskey, Cara Rada, Elizabeth Bailey, Samantha McCavera, Hugo A van den Berg, Jolene Atia, David A Rand, Anatoly Shmygol, Yi‐Wah Chan, Siobhan Quenby, Jan J Brosens, Manu Vatish, Jie Zhang, Jerod S Denton, Michael J Taggart, Catherine Kettleborough, David Tickle, Jeff Jerman, Paul Wright, Timothy Dale, Srinivasan Kanumilli, Derek J Trezise, Steve Thornton, Pamela Brown, Roberto Catalano, Nan Lin, Sarah K England, Andrew M Blanks
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 9, Pp 1161-1174 (2014)
Abstract Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including preterm birth, dysfunctional labour and post‐partum haemorrhage. Uterine contractile patterns are controlled by the generation of complex elec
Externí odkaz:
https://doaj.org/article/71bb4ab0b03e42c5af65876d7a37e163
Publikováno v:
Insects, Vol 9, Iss 4, p 163 (2018)
The inward rectifier potassium (Kir) channels play key roles in the physiology of mosquitoes and other insects. Our group, among others, previously demonstrated that small molecule inhibitors of Kir channels are promising lead molecules for developin
Externí odkaz:
https://doaj.org/article/bf6ce75edebe425d892984b9ff9fe598
Autor:
Jennifer L Herington, Daniel R Swale, Naoko Brown, Elaine L Shelton, Hyehun Choi, Charles H Williams, Charles C Hong, Bibhash C Paria, Jerod S Denton, Jeff Reese
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143243 (2015)
The uterine myometrium (UT-myo) is a therapeutic target for preterm labor, labor induction, and postpartum hemorrhage. Stimulation of intracellular Ca2+-release in UT-myo cells by oxytocin is a final pathway controlling myometrial contractions. The g
Externí odkaz:
https://doaj.org/article/f0f2083e05c54991a5f8cc8c6e99d788
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100700 (2014)
Mosquitoes are important disease vectors that transmit a wide variety of pathogens to humans, including those that cause malaria and dengue fever. Insecticides have traditionally been deployed to control populations of disease-causing mosquitoes, but
Externí odkaz:
https://doaj.org/article/fbcdfa1e9b0e48e481ae0f11a9325307
Autor:
Rene Raphemot, Matthew F Rouhier, Daniel R Swale, Emily Days, C David Weaver, Kimberly M Lovell, Leah C Konkel, Darren W Engers, Sean R Bollinger, Corey Hopkins, Peter M Piermarini, Jerod S Denton
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e110772 (2014)
Vector-borne diseases such as dengue fever and malaria, which are transmitted by infected female mosquitoes, affect nearly half of the world's population. The emergence of insecticide-resistant mosquito populations is reducing the effectiveness of co
Externí odkaz:
https://doaj.org/article/e02339d3e86b4ec08682a15b3ac994af