Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jerod L. Ptacin"'
Autor:
Jerod L. Ptacin, Lina Ma, Carolina E. Caffaro, Nicole V. Acuff, Kristine Germar, Peter Severy, Yanyan Qu, Jose-Luis Vela, Xinming Cai, Kristine M. San Jose, Hans R. Aerni, David B. Chen, Ean Esche, Taylor K. Ismaili, Rob Herman, Yelena Pavlova, Michael J. Pena, Jasmine Nguyen, Lilia K. Koriazova, Laura K. Shawver, Ingrid B. Joseph, Jill Mooney, Mark Peakman, Marcos E. Milla
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-16 (2024)
Abstract Background Natural cytokines are poorly suited as therapeutics for systemic administration due to suboptimal pharmacological and pharmacokinetic (PK) properties. Recombinant human interleukin-2 (rhIL-2) has shown promise for treatment of aut
Externí odkaz:
https://doaj.org/article/224e433676bd420da232e1c317680a2d
Autor:
Jerod L. Ptacin, Carolina E. Caffaro, Lina Ma, Kristine M. San Jose Gall, Hans R. Aerni, Nicole V. Acuff, Rob W. Herman, Yelena Pavlova, Michael J. Pena, David B. Chen, Lilia K. Koriazova, Laura K. Shawver, Ingrid B. Joseph, Marcos E. Milla
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The use of synthetic organisms could provide opportunities for discovery and advanced manufacturing of medical drugs. Here the authors use a semi-synthetic organism with an expanded genetic code to generate site-specific chemical modifications in hum
Externí odkaz:
https://doaj.org/article/1eeb5f339edc4637a3c9f0f0c17dcf95
Autor:
Jerod L. Ptacin, Ewa Folta-Stogniew, Adam M. Perez, Luis R. Comolli, Eseosa T. Ighodaro, Grant R. Bowman, Lucy Shapiro
Publikováno v:
Molecular Microbiology. 90:776-795
In Caulobacter crescentus, the PopZ polar scaffold protein supports asymmetric cell division by recruiting distinct sets of binding partners to opposite cell poles. To understand how polar organizing centres are established by PopZ, we investigated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8053fc7d4cbfa6a1591fb98595079db
https://doi.org/10.1111/mmi.12398
https://doi.org/10.1111/mmi.12398
Autor:
Alexander R. S. von Diezmann, Sean Quirin, Mikael P. Backlund, W. E. Moerner, Lucy Shapiro, Rafael Piestun, Ginni Grover, Andreas Gahlmann, Jerod L. Ptacin, Marissa K. Lee
Publikováno v:
Nano Letters. 13:987-993
We demonstrate quantitative multicolor three-dimensional (3D) subdiffraction imaging of the structural arrangement of fluorescent protein fusions in living Caulobacter crescentus bacteria. Given single-molecule localization precisions of 20-40 nm, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22816b340387063356a20d4825c035f9
https://doi.org/10.1021/nl304071h
https://doi.org/10.1021/nl304071h
Autor:
Carlos Bustamante, Jerod L. Ptacin, Paul J. Pease, David J. Sherratt, Oren Levy, Gregory J. Cost, Jeff Gore, Nicholas R. Cozzarelli
DNA translocases are molecular motors that move rapidly along DNA using adenosine triphosphate as the source of energy. We directly observed the movement of purified FtsK, an Escherichia coli translocase, on single DNA molecules. The protein moves at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2306758a8eedba0cc6da460b70cf9514
https://ora.ox.ac.uk/objects/uuid:756d27b3-b8ab-4163-8e84-87a5d0eb14d8
https://ora.ox.ac.uk/objects/uuid:756d27b3-b8ab-4163-8e84-87a5d0eb14d8
Autor:
Lucy Shapiro, Jerod L. Ptacin
Publikováno v:
Cellular Microbiology. 15:45-52
The bacterial chromosome encodes information at multiple levels. Beyond direct protein coding, genomes encode regulatory information required to orchestrate the proper timing and levels of gene expression and protein synthesis, and contain binding si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd8c473aa5caa17bb1a1f6c0182ed2dd
https://doi.org/10.1111/cmi.12049
https://doi.org/10.1111/cmi.12049
Autor:
Ethan C. Garner, Steven F. Lee, Esteban Toro, W. E. Moerner, Jerod L. Ptacin, Luis R. Comolli, Michael Eckart, Lucy Shapiro
Publikováno v:
Nature Cell Biology. 12:791-798
Until recently, a dedicated mitotic apparatus that segregates newly replicated chromosomes into daughter cells was believed to be unique to eukaryotic cells. Here we demonstrate that the bacterium Caulobacter crescentus segregates its chromosome usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1447739ab91dd5f291ffd9f5babb44
https://doi.org/10.1038/ncb2083
https://doi.org/10.1038/ncb2083
Autor:
Sigal Ben-Yehuda, David Z. Rudner, Marcelo Nollmann, Carlos Bustamante, Briana M. Burton, Jerod L. Ptacin, Kathleen A. Marquis
Publikováno v:
Genes & Development. 22:1786-1795
The FtsK/SpoIIIE family of DNA transporters are responsible for translocating missegregated chromosomes after the completion of cell division. An extreme example of this post-cytokinetic DNA segregation occurs during spore formation in the bacterium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd748946c92fb201d1b8d736ff33c31d
https://doi.org/10.1101/gad.1684008
https://doi.org/10.1101/gad.1684008
Publikováno v:
Molecular Microbiology
Tn5 transposition is a complicated process that requires the formation of a highly ordered protein-DNA structure, a synaptic complex, to catalyse the movement of a sequence of DNA (transposon) into a target DNA. Much is known about the structure of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12d1776b5a36596fe38837744c76cc9
https://doi.org/10.1111/j.1365-2958.2007.06056.x
https://doi.org/10.1111/j.1365-2958.2007.06056.x
Autor:
Cris V. Van Hout, Michael J. Moser, Jerod L. Ptacin, Craig S. Richmond, Christopher B. Sherrill, Jennifer K. Grenier, Sara J. Zanton, Collin D. Kieffer, David J. Marshall, Anthony A. Killeen, Christopher W. Scherrer, Eric B. Roesch, James R. Prudent
Publikováno v:
Clinical Chemistry. 49:407-414
Background: With the invention of the DNA chip, genome-wide analysis is now a reality. Unfortunately, solid-phase detection systems such as the DNA chip suffer from a narrow range in quantification and sensitivity. Today the best methodology for sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358f01cddce6c3ea63114d625fabe075
https://doi.org/10.1373/49.3.407
https://doi.org/10.1373/49.3.407