Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jerneja Kladnik"'
Autor:
Luka Rejc, Damijan Knez, Gabriela Molina-Aguirre, Alba Espargaró, Jerneja Kladnik, Anže Meden, Lana Blinc, Matic Lozinšek, Ross D. Jansen-van Vuuren, Matic Rogan, Bruno Aleksander Martek, Jernej Mlakar, Ana Dremelj, Andrej Petrič, Stanislav Gobec, Raimon Sabaté, Mara Bresjanac, Balazs Pinter, Janez Košmrlj
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116616- (2024)
Fluorescent probes are a powerful tool for imaging amyloid β (Aβ) plaques, the hallmark of Alzheimer’s disease (AD). Herein, we report the synthesis and comprehensive characterization of 21 novel probes as well as their optical properties and bin
Externí odkaz:
https://doaj.org/article/5dba3452cc3d4596945a7835ff379451
Autor:
Lana Blinc, Mateja Drolec Novak, Jernej Mlakar, Damijan Knez, Matic Rogan, Jerneja Kladnik, Ross Jansen-Van Vuuren, Janez Košmrlj, Maja Bresjanac
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S371- (2023)
Externí odkaz:
https://doaj.org/article/b88cf8f835b64d8bb4ec89d393ddcc3c
Autor:
Jerneja Kladnik, Ana Dolinar, Jakob Kljun, David Perea, Judith Grau-Expósito, Meritxell Genescà, Marko Novinec, Maria J. Buzon, Iztok Turel
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2158-2168 (2022)
Zinc pyrithione (1a), together with its analogues 1b–h and ruthenium pyrithione complex 2a, were synthesised and evaluated for the stability in biologically relevant media and anti-SARS-CoV-2 activity. Zinc pyrithione revealed potent in vitro inhib
Externí odkaz:
https://doaj.org/article/c5d1adac442a492aaa8f559c8cfcbc0e
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Selective photochemical oxidation of styrene was performed in an active acetonitrile medium, using H2O2 with or without ultraviolet (UV) light radiation. Pyrithione metal complexes (M–Pth: M = Cu(II), Ni(II), Ru(II); Pth = 2-mercaptopyridi
Externí odkaz:
https://doaj.org/article/22497ec5b5354ca486a1ef1f16903750
Autor:
Jakob Kljun, Mihaela Rebernik, Lucía M. Balsa, Jerneja Kladnik, Uroš Rapuš, Tomaž Trobec, Kristina Sepčić, Robert Frangež, Ignacio E. León, Iztok Turel
Publikováno v:
Molecules, Vol 28, Iss 6, p 2499 (2023)
Organoruthenium pyrithione (1-hydroxypyridine-2-thione) complexes have been shown in our recent studies to be a promising family of compounds for development of new anticancer drugs. The complex [(η6-p-cymene)Ru(pyrithionato)(pta)]PF6 contains phosp
Externí odkaz:
https://doaj.org/article/0bf0627171a9456fb44468bc7d49c0e4
Autor:
Tomaž Trobec, Monika C. Žužek, Kristina Sepčić, Jerneja Kladnik, Jakob Kljun, Iztok Turel, Evelyne Benoit, Robert Frangež
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 127, Iss , Pp 110161- (2020)
In addition to antibacterial and antitumor effects, synthetic ruthenium complexes have been reported to inhibit several medicinally important enzymes, including acetylcholinesterase (AChE). They may also interact with muscle-type nicotinic acetylchol
Externí odkaz:
https://doaj.org/article/eb12c927658748ed9ce994e8ab41032d
Autor:
Tomaž Trobec, Kristina Sepčić, Monika Cecilija Žužek, Jerneja Kladnik, Nina Podjed, Catarina Cardoso Páscoa, Iztok Turel, Robert Frangež
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1243 (2021)
Cholinesterases (ChEs) show increased activities in patients with Alzheimer’s disease, and remain one of the main therapeutic targets for treatment of this neurodegenerative disorder. A library of organoruthenium(II) complexes was prepared to inves
Externí odkaz:
https://doaj.org/article/7e0a392a6aed4096978e4a29155187f8
Autor:
Tamás Pivarcsik, Gábor Tóth, Nikoletta Szemerédi, Anita Bogdanov, Gabriella Spengler, Jakob Kljun, Jerneja Kladnik, Iztok Turel, Éva A. Enyedy
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 518 (2021)
In this work, the various biological activities of eight organoruthenium(II) complexes were evaluated to reveal correlations with their stability and reactivity in aqueous media. Complexes with general formula [Ru(η6-p-cymene)(X,Y)(Z)] were prepared
Externí odkaz:
https://doaj.org/article/68e7925729e148a1a140a161a25d66c4
Autor:
Katarina Marković, Radmila Milačič, Stefan Marković, Jerneja Kladnik, Iztok Turel, Janez Ščančar
Publikováno v:
Molecules, Vol 25, Iss 7, p 1512 (2020)
The development of ruthenium-based complexes for cancer treatment requires a variety of pharmacological studies, one of them being a drug’s binding kinetics to serum proteins. In this work, speciation analysis was used to study kinetics of rutheniu
Externí odkaz:
https://doaj.org/article/cfbd6800e9f14ff89b6d68317e1f0403
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2681
International journal of molecular sciences, vol. 24, no. 3, 2681, 2023.
Volume 24
Issue 3
Pages: 2681
International journal of molecular sciences, vol. 24, no. 3, 2681, 2023.
Enzyme butyrylcholinesterase (BChE) shows increased activity in some brain regions after progression of Alzheimer’s disease and is therefore one of the therapeutic targets for symptomatic treatment of this neurodegenerative disorder. The organoruth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63ea878b2fac56b8054c5e88914e77c