An Examination of the Effect of Aspirin and Salicylic Acid on Soluble Fms-like Tyrosine Kinase-1 Release from Human Placental Trophoblasts

Autor: Jiawu Zhao, Rui Duan, Jinghui Sun, Rebecca P. Chow, Timothy J. Lyons, Jeremy Y. Yu

Publikováno v: Cells, Vol 13, Iss 2, p 113 (2024)

Low-dose aspirin (LDA) is efficacious in preventing preeclampsia, but its mechanism of action is unclear. Conflicting evidence suggests that it may inhibit placental trophoblast release of soluble fms-like tyrosine kinase-1 (sFlt1), a key mediator of

Externí odkaz: https://doaj.org/article/d2327c7727c54a95b118b414b48d9920

Vitamin D Metabolites and Binding Protein Predict Preeclampsia in Women with Type 1 Diabetes

Autor: Clare B. Kelly, Carol L. Wagner, Judith R. Shary, Misti J. Leyva, Jeremy Y. Yu, Alicia J. Jenkins, Alison J. Nankervis, Kristian F. Hanssen, Satish K. Garg, James A. Scardo, Samar M. Hammad, Christopher E. Aston, Timothy J. Lyons

Publikováno v: Nutrients, Vol 12, Iss 7, p 2048 (2020)

The risk for preeclampsia (PE) is enhanced ~4-fold by the presence of maternal type 1 diabetes (T1DM). Vitamin D is essential for healthy pregnancy. We assessed the total, bioavailable, and free concentrations of plasma 25-hydroxyvitamin D (25(OH)D),

Externí odkaz: https://doaj.org/article/a299034631154e7da5b8b3554ba916ce

Comparisons of α2-Adrenergic Agents, Medetomidine and Xylazine, with Pentobarbital for Anesthesia: Important Pitfalls in Diabetic and Nondiabetic Rats

Autor: Anna R. Connell, Michelle B. Hookham, Dongxu Fu, Derek P. Brazil, Timothy J. Lyons, Jeremy Y. Yu

Publikováno v: Connell, A R, Hookham, M B, Fu, D, Brazil, D P, Lyons, T J & Yu, J Y 2021, ' Comparisons of α2-Adrenergic Agents, Medetomidine and Xylazine, with Pentobarbital for Anesthesia: Important Pitfalls in Diabetic and Nondiabetic Rats ', Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics . https://doi.org/10.1089/jop.2021.0084

Anesthesia is necessary to conduct rodent electroretinograms (ERGs). We evaluated utility of the α2-agonist medetomidine versus xylazine for ERG studies in nondiabetic and diabetic rats. Pentobarbital was included as a comparator. Male Sprague-Dawle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f1bc05bb1eab6b2970db6ad8a19ddb
https://doi.org/10.1089/jop.2021.0084

Differential regulation of a placental SAM68 and sFLT1 gene pathway and the relevance to maternal vitamin D sufficiency

Autor: Oyindamola Awe, Paul J. Nietert, James M. Sinkway, Carol L. Wagner, Quentell Wagener, Kyu-Ho Lee, Rebecca P. Chow, Jeremy Y. Yu, Elizabeth V. Schulz

Publikováno v: Pregnancy Hypertens

OBJECTIVE: The goal of this study was to determine if a previously observed axis of placental gene expression associated with early onset and severe preeclampsia (EOSPE) was operative in term pregnancy and correlated with vitamin D sufficiency. METHO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722cf2949af5e5778b5c87763b07e52e
https://doi.org/10.1016/j.preghy.2020.09.004

Vitamin D Metabolites and Binding Protein Predict Preeclampsia in Women with Type 1 Diabetes

Autor: Kristian F. Hanssen, James A. Scardo, Jeremy Y. Yu, Christopher E. Aston, Judith Shary, Alison Nankervis, Satish K. Garg, Timothy J. Lyons, Clare B. Kelly, Alicia J. Jenkins, Carol L. Wagner, Samar M. Hammad, Misti J. Leyva

Publikováno v: Nutrients, Vol 12, Iss 2048, p 2048 (2020)
Kelly, C B, Wagner, C L, Shary, J R, Leyva, M J, Yu, J Y, Jenkins, A J, Nankervis, A J, Hanssen, K F, Garg, S K, Scardo, J A, Hammad, S M, Aston, C E & Lyons, T J 2020, ' Vitamin D Metabolites and Binding Protein Predict Preeclampsia in Women with Type 1 Diabetes ', Nutrients, vol. 12, no. 7, 2048 . https://doi.org/10.3390/nu12072048
Nutrients
Volume 12
Issue 7

The risk for preeclampsia (PE) is enhanced ~4-fold by the presence of maternal type 1 diabetes (T1DM). Vitamin D is essential for healthy pregnancy. We assessed the total, bioavailable, and free concentrations of plasma 25-hydroxyvitamin D (25(OH)D),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f119bcf1f3e9ca2022cff10fc5dd28
https://www.mdpi.com/2072-6643/12/7/2048