Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jeremy W. Mason"'
Autor:
Liam Hudson, Jeremy W. Mason, Matthias V. Westphal, Matthieu J. R. Richter, Jonathan R. Thielman, Bruce K. Hua, Christopher J. Gerry, Guoqin Xia, Heather L. Osswald, John M. Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I. C. Tresco, Shuang Liu, Andrew G. Reidenbach, Katherine S. Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M. Gampe, Nichola J. Smith, James E. Bradner, Connor W. Coley, Paul A. Clemons, Bruno Melillo, C. Suk-Yee Hon, Johannes Ottl, Christoph E. Dumelin, Jonas V. Schaefer, Ann Marie E. Faust, Frédéric Berst, Stuart L. Schreiber, Frédéric J. Zécri, Karin Briner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Diversity-oriented synthesis (DOS) is a powerful strategy to prepare molecules with underrepresented features in commercial screening collections, resulting in the elucidation of novel biological mechanisms. In parallel to the development of
Externí odkaz:
https://doaj.org/article/36c9d05209eb47b1b03cc9fce00df87d
Autor:
Liam Hudson, Jeremy W. Mason, Matthias V. Westphal, Matthieu J. R. Richter, Jonathan R. Thielman, Bruce K. Hua, Christopher J. Gerry, Guoqin Xia, Heather L. Osswald, John M. Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I. C. Tresco, Shuang Liu, Andrew G. Reidenbach, Katherine S. Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M. Gampe, Nichola J. Smith, James E. Bradner, Connor W. Coley, Paul A. Clemons, Bruno Melillo, C. Suk-Yee Hon, Johannes Ottl, Christoph E. Dumelin, Jonas V. Schaefer, Ann Marie E. Faust, Frédéric Berst, Stuart L. Schreiber, Frédéric J. Zécri, Karin Briner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/d2f9e92baa034e31a3064fe3179e5c22
Autor:
Shuang Liu, Bingqi Tong, Jeremy W. Mason, Jonathan M. Ostrem, Antonin Tutter, Bruce K. Hua, Sunny A. Tang, Simone Bonazzi, Karin Briner, Frédéric Berst, Frédéric J. Zécri, Stuart L. Schreiber
Publikováno v:
bioRxiv
The hallmark of a molecular glue is its ability to induce cooperative protein–protein interactions, leading to the formation of a ternary complex, despite weaker binding towards one or both individual proteins. Notably, the extent of cooperativity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf3ad108fb04b6c68686d086e12b440
https://europepmc.org/articles/PMC10245867/
https://europepmc.org/articles/PMC10245867/
Autor:
Jeremy W. Mason, Liam Hudson, Matthias V. Westphal, Antonin Tutter, Gregory Michaud, Wei Shu, Xiaolei Ma, Connor W. Coley, Paul A. Clemons, Simone Bonazzi, Frédéric Berst, Frédéric J. Zécri, Karin Briner, Stuart L. Schreiber
Molecular glues and bifunctional compounds that induce protein–protein associations provide a powerful and general mechanism to modulate cell circuitry. We sought to develop a platform for the direct discovery of compounds able to induce associatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::353823b77fa8f321be337dcdf45df150
https://doi.org/10.1101/2022.10.13.512184
https://doi.org/10.1101/2022.10.13.512184
Autor:
Liam Hudson, Jeremy W. Mason, Matthias V. Westphal, Matthieu J. R. Richter, Jonathan R. Thielman, Bruce K. Hua, Christopher J. Gerry, Guoqin Xia, Heather L. Osswald, John M. Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I. C. Tresco, Shuang Liu, Andrew G. Reidenbach, Katherine S. Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M. Gampe, Nichola J. Smith, James E. Bradner, Connor W. Coley, Paul A. Clemons, Bruno Melillo, C. Suk-Yee Hon, Johannes Ottl, Christoph E. Dumelin, Jonas V. Schaefer, Ann Marie E. Faust, Frédéric Berst, Stuart L. Schreiber, Frédéric J. Zécri, Karin Briner
Diversity-oriented synthesis (DOS)is a powerful strategy to prepare molecules with underrepresented features in commercial screening collections, resulting in the elucidation of novel biological mechanisms. In parallel to the development of DOS, DNA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea89009e90b9f024b527255fb7155d39
https://doi.org/10.1101/2022.10.16.512431
https://doi.org/10.1101/2022.10.16.512431
Autor:
Katherine S. Lim, Andrew G. Reidenbach, Bruce K. Hua, Jeremy W. Mason, Christopher J. Gerry, Paul A. Clemons, Connor W. Coley
Publikováno v:
Journal of chemical information and modeling. 62(10)
DNA-encoded library (DEL) screening and quantitative structure-activity relationship (QSAR) modeling are two techniques used in drug discovery to find novel small molecules that bind a protein target. Applying QSAR modeling to DEL selection data can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b042cb995b3f460946c14530f9ccbe
https://pubmed.ncbi.nlm.nih.gov/35535861
https://pubmed.ncbi.nlm.nih.gov/35535861
Autor:
Karin Briner, Liam Hudson, Johan A Pradeilles, Matthias V Westphal, Jeremy W Mason, Stuart L. Schreiber, Frédéric Zecri
Publikováno v:
J Am Chem Soc
DNA-encoded libraries of small molecules are being explored extensively for the identification of binders in early drug-discovery efforts. Combinatorial syntheses of such libraries require water- and DNA-compatible reactions, and the paucity of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f0d19cdfb83e29c8e85a274dcbd595
https://doi.org/10.1021/jacs.9b13186
https://doi.org/10.1021/jacs.9b13186
Autor:
Matthias V. Westphal, Liam Hudson, Jeremy W. Mason, Frédéric J. Zécri, Karin Briner, Stuart L. Schreiber
DNA-encoded libraries of small molecules are being explored extensively for the identification of binders in early drug-discovery efforts. Combinatorial syntheses of such libraries require water- and DNA-compatible reactions, and the paucity of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5d037e4a6cb006eafa0ba4ff60e31e
https://doi.org/10.26434/chemrxiv.11342471
https://doi.org/10.26434/chemrxiv.11342471
Xanthates as Synthetic Equivalents of Oxyacyl Radicals: Access to Lactones under Tin-Free Conditions
Publikováno v:
The Journal of Organic Chemistry. 77:6332-6339
In addition to their utility in Barton-McCombie deoxygenations, xanthates can engage in 5-exo-trig radical cyclizations to afford lactones after oxidative workup. In this paper, we describe a tin-free protocol that provides direct access to lactones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c053959d72ffca43808922d728fb59f
https://doi.org/10.1021/jo300939f
https://doi.org/10.1021/jo300939f
Autor:
Jeremy E. Wulff, Martin J. Boulanger, Tracy Chan, Michael G. Brant, Jeremy W. Mason, Martine D. Lunke, Caleb M. Bromba, Martin Petric
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7137-7141
The guanidine function in the potent neuraminidase inhibitor peramivir was included early on in the drug design process, and examination of X-ray structural data for the enzyme-inhibitor complex would seem to indicate that the guanidine plays a criti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f98537d234a874ab9b3bf16f4177fb7
https://doi.org/10.1016/j.bmcl.2011.09.076
https://doi.org/10.1016/j.bmcl.2011.09.076