Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jeremy W. Linsley"'
Autor:
Jeremy W. Linsley, Kevan Shah, Nicholas Castello, Michelle Chan, Dominik Haddad, Zak Doric, Shijie Wang, Wiktoria Leks, Jay Mancini, Viral Oza, Ashkan Javaherian, Ken Nakamura, David Kokel, Steven Finkbeiner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Cell death is a critical process in health and disease, yet available markers record later stages of cell death once a cell has already begun to decompose. Here the authors show the use of a genetically encoded calcium indicator that demarcates an ir
Externí odkaz:
https://doaj.org/article/2c47160676034ab2bc322fd5c88405c2
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Neurotoxicity can be detected in live microscopy by morphological changes such as retraction of neurites, fragmentation, blebbing of the neuronal soma and ultimately the disappearance of fluorescently labeled neurons. However, quantification of these
Externí odkaz:
https://doaj.org/article/75df8dab1e564b4d8fae3634e2badcf2
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Stac3 regulates excitation-contraction coupling (EC coupling) in vertebrate skeletal muscles by regulating the L-type voltage-gated calcium channel (Cav channel). Recently a stac-like gene, Dstac, was identified in Drosophila and found to be expresse
Externí odkaz:
https://doaj.org/article/4d5487f3d3204588bf7575bb932ab900
Autor:
Jeremy W. Linsley, Nadia Perez, I-Uen Hsu, Yuyang Yang, Naveen Jasti, Matthew Waalkes, Eric J. Horstick, John Y. Kuwada
The stac family of genes are expressed by several cell types including neurons and muscles in a wide variety of animals. In vertebrates, stac3 encodes an adaptor protein specifically expressed by skeletal muscle that regulates L-type calcium channels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89c8abe0dbe4f9a70f8841d2f814173d
https://doi.org/10.1101/2022.08.24.505176
https://doi.org/10.1101/2022.08.24.505176
Autor:
Allison M Orzel, Richard I. Hume, Miranda C Lum, Lilly E. Reid, Catherine A. Collins, Jade E Varineau, Edwin S. Levitan, John Y. Kuwada, Haoxing Xu, Ari Leflein, Xiaoli Zhang, Jeremy W. Linsley, Drew A Berkhoudt, I-Uen Hsu
Publikováno v:
Proc Natl Acad Sci U S A
Significance Many neurons release neuropeptides as well as classical neurotransmitters. Neuropeptides often regulate neural circuits controlling behaviors such as emotional behaviors. However, how neuropeptide release is regulated is not well-underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144c861eee26045445989fff66ac1a7a
https://doi.org/10.1073/pnas.2009224117
https://doi.org/10.1073/pnas.2009224117
Autor:
Jeremy W. Linsley, Drew A. Linsley, Josh Lamstein, Gennadi Ryan, Kevan Shah, Nicholas A. Castello, Viral Oza, Jaslin Kalra, Shijie Wang, Zachary Tokuno, Ashkan Javaherian, Thomas Serre, Steven Finkbeiner
Publikováno v:
Science Advances
Science Advances, vol 7, iss 50
Science Advances, vol 7, iss 50
Description
High-throughput microscopy has outpaced analysis; biomarker-optimized CNNs are a generalizable, fast, and interpretable solution.
Cellular events underlying neurodegenerative disease may be captured by longitudinal live microsco
High-throughput microscopy has outpaced analysis; biomarker-optimized CNNs are a generalizable, fast, and interpretable solution.
Cellular events underlying neurodegenerative disease may be captured by longitudinal live microsco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26d4c3d0128624eceba3e84af17d814
https://doi.org/10.1126/sciadv.abf8142
https://doi.org/10.1126/sciadv.abf8142
Publikováno v:
Expert Opin Drug Discov
Expert opinion on drug discovery, vol 14, iss 9
Expert opinion on drug discovery, vol 14, iss 9
Introduction: Neurodegenerative diseases affect millions of people worldwide. Neurodegeneration is gradual over time, characterized by neuronal death that causes deterioration of cognitive or motor functions, ultimately leading to the patient's death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731e89e17ebd80b6703cd295d00a93ae
https://doi.org/10.1080/17460441.2019.1623784
https://doi.org/10.1080/17460441.2019.1623784
Autor:
Phil Synder, Jeremy W. Linsley, Kenneth Daily, Irina Epstein, Larsson Omberg, Steve Finkbeiner, Young Hwan Chang, Josh Lamstein, Mariya, Laura M. Heiser, Jaslin Kalra
Publikováno v:
CDC
Live-cell imaging is an important technique to study cell migration and proliferation as well as image-based profiling of drug perturbations over time. To gain biological insights from live-cell imaging data, it is necessary to identify individual ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9de406e2b1044f3853bb71acd89b17a
https://doi.org/10.1101/2020.08.20.259408
https://doi.org/10.1101/2020.08.20.259408
Autor:
Jeremy W. Linsley, Ashkan Javaherian, Josh Lamstein, Viral Oza, Steven Finkbeiner, Gennadi Ryan, Zachary Tokuno, Drew Linsley, Shijie Wang, Thomas Serre, Kevan Shah, Jaslin Kalra, Nicholas A. Castello
Cell death is an essential process in biology that must be accounted for in live microscopy experiments. Nevertheless, cell death is difficult to detect without perturbing experiments with stains, dyes or biosensors that can bias experimental outcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b99f9521d2fa22b89e646e6c84bcbaed
https://doi.org/10.1101/2020.08.04.237032
https://doi.org/10.1101/2020.08.04.237032
Autor:
Jeremy W. Linsley, Kevan Shah, Nicholas Castello, Michelle Chan, Dominic Haddad, Jay Mancini, Viral Oza, Shijie Wang, Ashkan Javaherian, David Kokel, Steven Finkbeiner
Cell death is a critical process that occurs normally in health and disease. However, its study is limited due to available technologies that only detect very late stages in the process or specific death mechanisms. Here, we report the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ab6998882c781813ff8de9c9ad3ce8