Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jeremy T. Lant"'
Autor:
Lei Jin, Ziyang Yu, Aaron Au, Peter Serles, Nan Wang, Jeremy T. Lant, Tobin Filleter, Christopher M. Yip
Publikováno v:
HardwareX, Vol 17, Iss , Pp e00508- (2024)
We present the design of a low-cost, portable telecentric digital holographic microscope (P-TDHM) that utilizes off-the-shelf components. We describe the system’s hardware and software elements and evaluate its performance by imaging samples rangin
Externí odkaz:
https://doaj.org/article/2cb610f9a60247ac90375345c16e8040
Autor:
Samuel S. Slattery, Daniel J. Giguere, Emily E. Stuckless, Arina Shrestha, Lee-Ann K. Briere, Alexa Galbraith, Stephen Reaume, Xenia Boyko, Henry H. Say, Tyler S. Browne, Mallory I. Frederick, Jeremy T. Lant, Ilka U. Heinemann, Patrick O’Donoghue, Liann Dsouza, Steven Martin, Peter Howard, Christopher Jedeszko, Kinza Ali, Garth Styba, Martin Flatley, Bogumil J. Karas, Gregory B. Gloor, David R. Edgell
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The worldwide COVID-19 pandemic caused by the SARS-CoV-2 betacoronavirus has highlighted the need for a synthetic biology approach to create reliable and scalable sources of viral antigen for uses in diagnostics, therapeutics and basic biome
Externí odkaz:
https://doaj.org/article/addb994c28b44678acdeb227ced926e1
Autor:
Peter Rozik, Robert Szabla, Jeremy T. Lant, Rashmi Kiri, David E. Wright, Murray Junop, Patrick O’Donoghue
Publikováno v:
RNA Biology. 19:220-232
High-fidelity translation was considered a requirement for living cells. The frozen accident theory suggested that any deviation from the standard genetic code should result in the production of so much mis-made and non-functional proteins that cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5de92fb8cfd3c78ed1b83aff95521f3
https://doi.org/10.1080/15476286.2021.2015173
https://doi.org/10.1080/15476286.2021.2015173
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 378
By linking amino acids to their codon assignments, transfer RNAs (tRNAs) are essential for protein synthesis and translation fidelity. Some human tRNA variants cause amino acid mis-incorporation at a codon or set of codons. We recently found that a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb25a4f3cd8135a138d30c796ec36d23
https://doi.org/10.1098/rstb.2022.0029
https://doi.org/10.1098/rstb.2022.0029
Publikováno v:
Nucleic Acids Research
In neurodegenerative diseases, including pathologies with well-known causative alleles, genetic factors that modify severity or age of onset are not entirely understood. We recently documented the unexpected prevalence of transfer RNA (tRNA) mutants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9378af5ab8f09f4024913d18a561ea98
http://europepmc.org/articles/PMC8599886
http://europepmc.org/articles/PMC8599886
Publikováno v:
Genes
Volume 14
Issue 2
Pages: 518
Volume 14
Issue 2
Pages: 518
High-fidelity protein synthesis requires properly aminoacylated transfer RNAs (tRNAs), yet diverse cell types, from bacteria to humans, show a surprising ability to tolerate errors in translation resulting from mutations in tRNAs, aminoacyl-tRNA synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50618e28fa9c8b696c920213147f8498
https://doi.org/10.3390/genes14020518
https://doi.org/10.3390/genes14020518
Autor:
Samuel S. Slattery, Daniel J. Giguere, Emily E. Stuckless, Arina Shrestha, Lee-Ann K. Briere, Alexa Galbraith, Stephen Reaume, Xenia Boyko, Henry H. Say, Tyler S. Browne, Mallory I. Frederick, Jeremy T. Lant, Ilka U. Heinemann, Patrick O’Donoghue, Liann Dsouza, Steven Martin, Peter Howard, Christopher Jedeszko, Kinza Ali, Garth Styba, Martin Flatley, Bogumil J. Karas, Gregory B. Gloor, David R. Edgell
Publikováno v:
Scientific reports. 12(1)
The worldwide COVID-19 pandemic caused by the SARS-CoV-2 betacoronavirus has highlighted the need for a synthetic biology approach to create reliable and scalable sources of viral antigen for uses in diagnostics, therapeutics and basic biomedical res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d174156761934a5ded90634e359680ab
https://pubmed.ncbi.nlm.nih.gov/35487958
https://pubmed.ncbi.nlm.nih.gov/35487958
Autor:
John F. Robinson, Patrick O'Donoghue, Julie Genereaux, Robert A. Hegele, Christopher J. Brandl, Daniel J. Giguere, Jian Wang, Matthew D. Berg, Jeremy T. Lant, Gregory B. Gloor, Calwing Liao, Jacqueline S. Dron
Publikováno v:
RNA Biology
Transfer RNAs are required to translate genetic information into proteins as well as regulate other cellular processes. Nucleotide changes in tRNAs can result in loss or gain of function that impact the composition and fidelity of the proteome. Despi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99b2d50a9794953a2a21c3e532c9868
http://europepmc.org/articles/PMC6779403
http://europepmc.org/articles/PMC6779403
Autor:
Ilka U. Heinemann, Christopher J. Brandl, Patrick O'Donoghue, Jeremy T. Lant, Matthew D. Berg
Publikováno v:
Journal of Biological Chemistry. 294:5294-5308
Perfectly accurate translation of mRNA into protein is not a prerequisite for life. Resulting from errors in protein synthesis, mistranslation occurs in all cells, including human cells. The human genome encodes >600 tRNA genes, providing both the ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318fc9d4edf9882c4bba071127003090
https://doi.org/10.1074/jbc.rev118.002982
https://doi.org/10.1074/jbc.rev118.002982
Autor:
Teah Jazey, Jeremy T. Lant, Zachary Klassen, Helen Wang, Isabel Desgagné-Penix, Jasmine A. Therrien, Samuel S Slattery, Bogumil J. Karas, Andrew Diamond, Kyle Lee, David R. Edgell
Publikováno v:
ACS Synthetic Biology. 7:328-338
With the completion of the genome sequence, and development of an efficient conjugation-based transformation system allowing the introduction of stable episomes, Phaeodactylum tricornutum has become an ideal platform for the study of diatom biology a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27fc3295e3c50cd9673c8450d704863
https://doi.org/10.1021/acssynbio.7b00191
https://doi.org/10.1021/acssynbio.7b00191