Synthesis of indolo[2,3-a]carbazole glycoside analogs of rebeccamycin: inhibitors of cyclin D1-CDK4

Autor: Concha Sanchez-Martinez, Jeremy T. Cooper, Leonard L. Winneroski, John L. Grutsch, Chuan Shih, Margaret M. Faul, Kevin A. Sullivan

Publikováno v: Tetrahedron Letters. 45:1095-1098

The synthesis and structure–activity relationships of a new series of indolo[2,3- a ]carbazole glycosides, analogs of rebeccamycin, derived from the natural sugars (glucose, fucose, mannose, xylose, rhamnose, and galactose) is described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::835c35143ef35e384d293e37d7e2626d
https://doi.org/10.1016/j.tetlet.2003.10.184

(S)​-​(-​)​-​4-​(2-​methylpropyl)​-​2-​(2-​pyridyl)​-​2-​oxazoline

Autor: Jérôme Lacour, Martina Austeri, Jeremy T. Cooper

Publikováno v: Handbook of Reagents for Organic Synthesis: Catalytic Oxidation Reagents pp. 388-390
e-EROS Encyclopedia of Reagents for Organic Synthesis
Encyclopedia of Reagents for Organic Synthesis

[108915-07-7] C12H16N2O (MW 204.27) InChI = 1S/C12H16N2O/c1-9(2)7-10-8-15-12(14-10)11-5-3-4-6-13-11/h3-6,9-10H,7-8H2,1-2H3/t10-/m0/s1 InChIKey = MFEIEQDUFOSLGN-JTQLQIEISA-N (chiral ligand for enantiocontrol of metal-catalyzed reactions) Physical Data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b61f089bcd3f900649b757d3927f34
https://archive-ouverte.unige.ch/unige:36203

Synthesis of aryl- and heteroaryl[a]pyrrolo[3,4-c]carbazoles

Autor: Stanley P. Kokis, Jeremy T. Cooper, Kevin A. Sullivan, John L. Grutsch, Margaret M. Faul, Chuan Shih, Concha Sanchez-Martinez

Publikováno v: The Journal of organic chemistry. 68(21)

Synthesis of aryl- and hetero[a]pyrrolo[3,4-c]carbazoles by photochemical oxidation and Heck cyclization are described. Photochemical oxidation of 2-naphthyl indolyl maleimide affords two different carbazole regioisomers, depending on the reaction co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c73a0dbc7a89b80d512964c712f37b5
https://pubmed.ncbi.nlm.nih.gov/14535777

Acyclic stereoselective boron alkylation reactions for the asymmetric synthesis of beta-substituted alpha-amino acid derivatives

Autor: Mary M. Mader, Jeremy T. Cooper, Martin J. O'Donnell

Publikováno v: Journal of the American Chemical Society. 125(9)

Optically active syn- or anti-beta-substituted-alpha-amino acid derivatives are prepared in 94 to/=99% ee and 66-98% ds by reaction of the Schiff base acetate of glycine tert-butyl ester with chiral, nonracemic B-alkyl-9-BBN derivatives in the presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e828d1c8959b4c075cd28c2661c6b93d
https://pubmed.ncbi.nlm.nih.gov/12603106

Solution phase synthesis of libraries of variably substituted olefin scaffolds: a library of allylic amines

Autor: Darrin Mayhew, Craig E. Dixon, Stephen W. Kaldor, Jeremy T. Cooper, Michael G. Organ, Miles Goodman Siegel, David J. Lavorato

Publikováno v: Journal of combinatorial chemistry. 3(1)

The synthesis of allylic amine libraries derived from olefin templates is described. The two-step, solution phase reaction sequence consists of amination of the template followed by Suzuki coupling and expedited purification via ion exchange chromato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f49757650b5bb9383ddc5093f9d56d52
https://pubmed.ncbi.nlm.nih.gov/11148064