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of 4
pro vyhledávání: '"Jeremy T-H. Chang"'
Autor:
Jeremy T-H. Chang, Shibai Li, Emily C. Beckwitt, Thane Than, Cory Haluska, Joshua Chandanani, Michael E. O’Donnell, Xiaolan Zhao, Shixin Liu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Using single-molecule visualization and manipulation, Chang et al. show that the eukaryotic Smc5/6 complex preferentially binds to and stabilizes ssDNA-dsDNA junctions, which could serve as the molecular basis for its diverse roles in genome maintena
Externí odkaz:
https://doaj.org/article/2e0ce673a1a9497cb9e6ee2939131165
Autor:
Tuan Nguyen, Sai Li, Jeremy T-H Chang, John W. Watters, Htet Ng, Adewola Osunsade, Yael David, Shixin Liu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Here the authors used single-molecule imaging and manipulation to study the mechanical effects of transcription factor Sox2 co-condensation with DNA and chromatin. They found that Sox2 condensates exert a high level of mechanical stress on DNA, but t
Externí odkaz:
https://doaj.org/article/a5fc41cecb574669a410977790cd6293
Autor:
Tuan Nguyen, Sai Li, Jeremy T-H Chang, John W. Watters, Htet Ng, Adewola Osunsade, Yael David, Shixin Liu
Publikováno v:
Nature communications. 13(1)
Formation of biomolecular condensates constitutes an emerging mechanism for transcriptional regulation. Recent studies suggest that the co-condensation between transcription factors (TFs) and DNA can generate mechanical forces driving genome rearrang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19b56072e744a79346f5cfe5c7ab082
https://pubmed.ncbi.nlm.nih.gov/35810158
https://pubmed.ncbi.nlm.nih.gov/35810158
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168284 (2016)
Breast cancer is the second-most common cancer and second-leading cause of cancer mortality in American women. The dysregulation of microRNAs (miRNAs) plays a key role in almost all cancers, including breast cancer. We comprehensively analyzed miRNA
Externí odkaz:
https://doaj.org/article/09e89cbd8d12462384099bee85873b2f