Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation

Autor: Pazhanichamy Kalailingam, Hui Bing Tan, Neeraj Jain, Ming Keat Sng, Jeremy Soon Kiat Chan, Nguan Soon Tan, Thirumaran Thanabalu

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Abstract Neural-Wiskott Aldrich Syndrome Protein (N-WASP) is expressed ubiquitously and regulates actin cytoskeleton remodeling. In order to characterize the role of N-WASP in epidermal homeostasis and cutaneous biology, we generated conditional N-WA

Externí odkaz: https://doaj.org/article/fc361caafd504099aa1586a2013021c0

ROS release by PPARβ/δ-null fibroblasts reduces tumor load through epithelial antioxidant response

Autor: Chek Kun Tan, Jeremy Soon Kiat Chan, Ming Keat Sng, Ivan Shun Bo How, Jiapeng Chen, Nguan Soon Tan, Walter Wahli, Eddie Han Pin Tan

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2018, ⟨10.1038/s41388-017-0109-8⟩
Oncogene, . (2018)
Oncogene, vol. 37, no. 15, pp. 2067-2078

Tumor stroma has an active role in the initiation, growth, and propagation of many tumor types by secreting growth factors and modulating redox status of the microenvironment. Although PPARβ/δ in fibroblasts was shown to modulate oxidative stress i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90dba0839e5e7cbe6786f08970b1780e
https://doi.org/10.1038/s41388-017-0109-8

Selective deletion of PPAR beta/delta in fibroblasts causes dermal fibrosis by attenuated LRG1 expression

Autor: Ya Lin Tnay, Terri Phua, Mintu Pal, Shunsuke Chiba, Ming Keat Sng, Jia Peng Chen, Jonathan Wei Kiat Wee, Jeremy Soon Kiat Chan, Benny Meng Kiat Tong, Walter Wahli, Eddie Han Pin Tan, Nguan Soon Tan, Ziqiang Teo, Nikki Jun Ning Koh, Xuan Rui Ng, Xiaomeng Wang, Pengcheng Zhu, Chek Kun Tan

Publikováno v: Cell Discovery
Cell Discovery, 2018, 4, ⟨10.1038/s41421-018-0014-5⟩
Cell Discovery, Vol 4, Iss 1, Pp 1-16 (2018)
Cell Discovery (4), . (2018)
Cell discovery, vol. 4, pp. 15

Connective tissue diseases of the skin are characterized by excessive collagen deposition in the skin and internal organs. Fibroblasts play a pivotal role in the clinical presentation of these conditions. Nuclear receptor peroxisome-proliferator acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aeba379b0856a59b339eea783f2354f
https://hal.inrae.fr/hal-02628817/document

Angiopoietin-like 4 Stimulates STAT3-mediated iNOS Expression and Enhances Angiogenesis to Accelerate Wound Healing in Diabetic Mice

Autor: Chi Qin Goh, Jeremy Soon Kiat Chan, Natalia V. Gounko, Marcus Thien Chong Wong, Sander Kersten, Nguan Soon Tan, Han Chung Chong, Baiwen Luo, Xiaoling Wang, Selin Foo, Cleo Choong

Publikováno v: Molecular Therapy 22 (2014) 9
Molecular Therapy, 22(9), 1593-1604

Impaired wound healing is a major source of morbidity in diabetic patients. Poor outcome has, in part, been related to increased inflammation, poor angiogenesis, and deficiencies in extracellular matrix components. Despite the enormous impact of thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e879a021385761cea0712ee66c852656

Targeting nuclear receptors in cancer-associated fibroblasts as concurrent therapy to inhibit development of chemoresistant tumors

Autor: J S Twang, Ziqiang Teo, Ming Keat Sng, Han Chung Chong, Nguan Soon Tan, Jeremy Soon Kiat Chan

Publikováno v: Oncogene

Most anticancer therapies to date focus on druggable features of tumor epithelia. Despite the increasing repertoire of treatment options, patient responses remain varied. Moreover, tumor resistance and relapse remain persistent clinical challenges. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f93c92b6947282bfce07f82183be2c
http://hdl.handle.net/10220/48495