The transfer of multigene panel testing for hereditary breast and ovarian cancer to healthcare: What are the implications for the management of patients and families?

Autor: Marie Eliade, Jeremy Skrzypski, Amandine Baurand, Caroline Jacquot, Geoffrey Bertolone, Catherine Loustalot, Charles Coutant, France Guy, Pierre Fumoleau, Yannis Duffourd, Laurent Arnould, Alexandra Delignette, Marie-Martine Padéano, Côme Lepage, Géraldine Raichon-Patru, Axelle Boudrant, Marie-Christine Bône-Lépinoy, Anne-Laure Villing, Aurélie Charpin, Karine Peignaux, Sandy Chevrier, Frédérique Vegran, François Ghiringhelli, Romain Boidot, Nicolas Sevenet, Sarab Lizard, Laurence Faivre

Publikováno v: Oncotarget
Oncotarget, Impact journals, 2017, 8 (2), pp.1957-1971. 〈http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path=12699&pubmed-linkout=1〉. 〈10.18632/oncotarget.12699〉
Oncotarget, Impact journals, 2017, 8 (2), pp.1957-1971. ⟨10.18632/oncotarget.12699⟩

IF 5.008 (2015/2016); International audience; Until recently, the molecular diagnosis of hereditary breast and ovarian cancer (HBOC) was mostly based on BRCA1/2 testing. Next generation sequencing and the recent discovery of new genes involved in HBO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3e57cdb27eb854c758930ccf5b719d
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01527309

Effect of dietary polyunsaturated fatty acids on the expression of peroxisomal ABC transporters

Autor: Franck Bonnetain, Catherine Gondcaille, Sabrina Leclercq, Stéphane Savary, Michel Narce, Agnès André, Anne Courvoisier, Jérôme Bellenger, Jean-Michel Chardigny, Jeremy Skrzypski, Sandrine Bellenger

Publikováno v: Biochimie. 90:1602-1607

Peroxisomal ABC transporters encoded by the ABCD genes are thought to participate in the import of specific fatty acids in the peroxisomal matrix. ABCD1 deficiency is associated with X-linked adrenoleukodystrophy (X-ALD), the most frequent peroxisoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba230885ca5bcf922e59351706cf519
https://doi.org/10.1016/j.biochi.2008.05.022

Impact du bévacizumab ajouté à un traitement de radiochimiothérapie par témozolamide sur le temps jusqu’à détérioration de la qualité de vie chez des patients atteints d’un glioblastome non résécable

Autor: Jeremy Skrzypski, S. Dabakuyo, C. Dalban, Olivier Chinot, L. Feuvret, Amélie Anota, Astrid Pozet, L. Taillandier, B. Chauffert, Chantal Campello

Publikováno v: Revue d'Épidémiologie et de Santé Publique. 63:S62-S63

Introduction Le pronostic des patients atteints d’un glioblastome non resecable reste mauvais, malgre un traitement par radiochimiotherapie a base de temozolamide (TMZ). Un essai clinique francais de phase II a recemment evalue l’adjonction du be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4ff2639d7ed094981ba9976b8dea1c0
https://doi.org/10.1016/j.respe.2015.03.057

Revisiting delta-6 desaturase regulation by C18 unsaturated fatty acids, depending on the nutritional status

Autor: Mickaël Rialland, J.-P. Poisson, Christian Tessier, Andrew J. Sinclair, Jeremy Skrzypski, Jérôme Bellenger, Michel Narce, Sandrine Bellenger

Publikováno v: Biochimie. 91(11-12)

Dietary polyunsaturated fatty acids (PUFA) play a key role in regulating delta-6 desaturase (D6D), the key enzyme for long-chain PUFA biosynthesis. Nevertheless, the extent of their effects on this enzyme remains controversial and difficult to assess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5308fb74e7b07cbe18388af7d77c43a3
https://pubmed.ncbi.nlm.nih.gov/19679157

Phase I dose escalation study of oral lapatinib in combination with docetaxel in patients with HER2-positive locally advanced or metastatic breast cancer (LAMBC): Initial safety and tolerability results

Autor: Bruno Coudert, Cristian Moldovan, Pierre Fumoleau, Jeremy Skrzypski, Mélanie Gauthier, Corinne Veyret, Jacques Bonneterre, Cécile Guillemet, Séverine Guiu, Nicolas Isambert, Florence Dalenc, Audrey Mailliez, Sylvie Zanetta

Publikováno v: Journal of Clinical Oncology. 31:e11529-e11529

e11529 Background: Previous studies evidenced that the combination docetaxel (D) (75 mg/m²) + lapatinib (L) (1,250 mg/d) is well tolerated in heavily pretreated HER2-positive metastatic breast cancer patients (pts) in association with systematic G-C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16dc6e800000ab40b260848425acca1e
https://doi.org/10.1200/jco.2013.31.15_suppl.e11529