Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Jeremy Saklatvala"'
Autor:
Jonathan Crowe, Anna Aubareda, Kay McNamee, Paulina M Przybycien, Xin Lu, Richard O Williams, George Bou-Gharios, Jeremy Saklatvala, Jonathan L E Dean
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77383 (2013)
There is large literature describing in vitro experiments on heat shock protein (hsp)B1 but understanding of its function in vivo is limited to studies in mice overexpressing human hspB1 protein. Experiments in cells have shown that hspB1 has chapero
Externí odkaz:
https://doaj.org/article/5e0d1e534624428a84b6788f6b5660f1
Autor:
Holger Buss, Katja Handschick, Nadine Jurrmann, Pirita Pekkonen, Knut Beuerlein, Helmut Müller, Robin Wait, Jeremy Saklatvala, Päivi M Ojala, M Lienhard Schmitz, Michael Naumann, Michael Kracht
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51847 (2012)
Nuclear factor kappa-B (NF-κB) activates multiple genes with overlapping roles in cell proliferation, inflammation and cancer. Using an unbiased approach we identified human CDK6 as a novel kinase phosphorylating NF-κB p65 at serine 536. Purified a
Externí odkaz:
https://doaj.org/article/f0f07af112614169b2d732e1310cee77
Autor:
Jeremy Saklatvala
Publikováno v:
Biological Regulation of the Chondrocytes ISBN: 9781315138329
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e16ca3d690390152770568b5f4e45c49
https://doi.org/10.1201/9781315138329-7
https://doi.org/10.1201/9781315138329-7
Autor:
Jeremy Saklatvala
Publikováno v:
Osteoarthritis and Cartilage. 29:1094-1095
Publikováno v:
BioMed Research International, Vol 2020 (2020)
BioMed Research International
BioMed Research International
Adult articular cartilage synthesises very little type II collagen in comparison to young cartilage. The age-related difference in collagen II synthesis is poorly understood. This is the first systematic investigation of age-related differences in ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98564af77fefdd947ca10066cf1d3c3d
https://doi.org/10.1155/2020/4060135
https://doi.org/10.1155/2020/4060135
Autor:
Heba M. Ismail, Jeremy Saklatvala, Kazuhiro Yamamoto, Hideaki Nagase, Linda Troeberg, Tonia L. Vincent
Publikováno v:
Arthritis & Rheumatology. 67:1826-1836
OBJECTIVE: Aggrecan enables articular cartilage to bear load and resist compression. Aggrecan loss occurs early in osteoarthritis and rheumatoid arthritis and can be induced by inflammatory cytokines such as interleukin-1 (IL-1). IL-1 induces cleavag
Autor:
Jeremy Saklatvala, George Bou-Gharios, C. Driscoll, Tonia L. Vincent, A Burleigh, Hideaki Nagase, Anastasios Chanalaris, Gardiner
Publikováno v:
Osteoarthritis and Cartilage
Summary Objective Identify gene changes in articular cartilage of the medial tibial plateau (MTP) at 2, 4 and 8 weeks after destabilisation of the medial meniscus (DMM) in mice. Compare our data with previously published datasets to ascertain dysregu
Autor:
Jeremy Saklatvala, Leandro Lo Cascio, Anastasios Chanalaris, Ngee Han Lim, George Bou-Gharios, Grace Chu, Hiro Nakamura, Hideaki Nagase, Ke Liu
Publikováno v:
genesis. 52:110-119
We have used an aggrecan gene enhancer to generate a transgenic murine line (Acan-CreER-Ires-Luc) expressing firefly luciferase and tamoxifen activatable Cre recombinase (Cre-ER(T2) ). The expression and efficiency of the inducible Cre recombinase ac
p38 mitogen-activated protein kinase (MAPK) is activated by inflammatory stimuli such as bacterial lipopolysaccharide (LPS), interleukin-1, and tumor necrosis factor. We have previously shown that the pyridinyl imidazole SB 203580, which inhibits it,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124eba157ce1f14ccbf264103ca116c6
https://doi.org/10.1074/jbc.274.1.264
https://doi.org/10.1074/jbc.274.1.264