Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Jeremy S Dittman"'
Autor:
Evan Quon, Yves Y Sere, Neha Chauhan, Jesper Johansen, David P Sullivan, Jeremy S Dittman, William J Rice, Robin B Chan, Gilbert Di Paolo, Christopher T Beh, Anant K Menon
Publikováno v:
PLoS Biology, Vol 16, Iss 5, p e2003864 (2018)
Tether proteins attach the endoplasmic reticulum (ER) to other cellular membranes, thereby creating contact sites that are proposed to form platforms for regulating lipid homeostasis and facilitating non-vesicular lipid exchange. Sterols are synthesi
Externí odkaz:
https://doaj.org/article/efa2ddef75a04ab9ab955fc705402e73
Publikováno v:
eLife, Vol 3 (2014)
The presynaptic protein complexin (CPX) is a critical regulator of synaptic vesicle fusion, but the mechanisms underlying its regulatory effects are not well understood. Its highly conserved central helix (CH) directly binds the ternary SNARE complex
Externí odkaz:
https://doaj.org/article/7e8d9e91972044a29909d61497abf177
Autor:
Helene Jahn, Ladislav Bartoš, Grace I. Dearden, Jeremy S. Dittman, Joost C. M. Holthuis, Robert Vácha, Anant K. Menon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Mitochondria are double-membrane-bounded organelles that depend critically on phospholipids supplied by the endoplasmic reticulum. These lipids must cross the outer membrane to support mitochondrial function, but how they do this is unclear.
Externí odkaz:
https://doaj.org/article/80090a11e13246b496e3a818de0be8af
Autor:
Yining Jiang, Batiste Thienpont, Vinay Sapuru, Richard K. Hite, Jeremy S. Dittman, James N. Sturgis, Simon Scheuring
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
High-Speed Atomic Force Microscopy movies of membrane proteins — diffusing and interacting in bilayers of controlled thickness — allow the determination of membrane-mediated membrane protein interaction energetics.
Externí odkaz:
https://doaj.org/article/d822ed8623bd4dad8e0d6482980b0861
Autor:
Guoqing, Xiang, Amanda, Acosta-Ruiz, Arthur, Radoux-Mergault, Melanie, Kristt, Jihye, Kim, Jared D, Moon, Johannes, Broichhagen, Asuka, Inoue, Francis S, Lee, Miriam, Stoeber, Jeremy S, Dittman, Joshua, Levitz
Publikováno v:
Science advances. 8(47)
Numerous processes contribute to the regulation of G protein-coupled receptors (GPCRs), but relatively little is known about rapid mechanisms that control signaling on the seconds time scale or regulate cross-talk between receptors. Here, we reveal t
Autor:
Guoqing Xiang, Amanda Acosta-Ruiz, Arthur Radoux-Mergault, Melanie Kristt, Jihye Kim, Jared D. Moon, Johannes Broichhagen, Asuka Inoue, Francis S. Lee, Miriam Stoeber, Jeremy S. Dittman, Joshua Levitz
Publikováno v:
Science Advances. 8
Numerous processes contribute to the regulation of G protein–coupled receptors (GPCRs), but relatively little is known about rapid mechanisms that control signaling on the seconds time scale or regulate cross-talk between receptors. Here, we reveal
Autor:
Fang Jiao, François Dehez, Tao Ni, Xiulian Yu, Jeremy S. Dittman, Robert Gilbert, Christophe Chipot, Simon Scheuring
Publikováno v:
Nature Communications. 13
Perforin-2 (PFN2, MPEG1) is a pore-forming protein that acts as a first line of defense in the mammalian immune system, rapidly killing engulfed microbes within the phagolysosome in macrophages. PFN2 self-assembles into hexadecameric pre-pore rings t
Publikováno v:
Journal of Molecular Biology. 435:167774
The molecules and mechanisms behind chemical synaptic transmission have been explored for decades. For several of the core proteins involved in synaptic vesicle fusion, we now have a reasonably detailed grasp of their biochemical, structural, and fun
Autor:
Jeremy S. Dittman
Publikováno v:
Curr Opin Neurobiol
Nervous systems are built on synaptic connections, and our understanding of these complex compartments has deepened over the past quarter century as the diverse fields of genetics, molecular biology, physiology, and biochemistry each made significant
Autor:
Jeremy S. Dittman, Timothy A. Ryan
Publikováno v:
Nature Reviews Neuroscience. 20:177-186
Exocytosis is a fundamental membrane fusion process by which the soluble or membrane-associated cargoes of a secretory vesicle are delivered to the extracellular milieu or the cell surface. While essential for all organs, the brain relies on a specia