Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jeremy R. Kenseth"'
Publikováno v:
Journal of Pharmaceutical Sciences. 97:2581-2606
Evaluation of a multiplexed capillary electrophoresis (CE) method for pK(a) measurements of organic compounds, including low solubility compounds, is presented. The method is validated on a set of 105 diverse compounds, mostly drugs, and results are
Autor:
Kenneth R. Wehmeyer, Yingkun Jin, William R. Heineman, Jeremy R. Kenseth, Mark Edward Stella, Caixia Zhou
Publikováno v:
Journal of Pharmaceutical Sciences. 94:576-589
A rapid approach for estimating the pK(a) value of small organic molecules was developed using vacuum-assisted multiplexed capillary electrophoresis (VAMCE) with ultraviolet detection. The VAMCE method employed a 96-capillary array, arranged in a sta
Publikováno v:
Drug Discovery Today. 9:1072-1080
The demand for high-throughput analytical tools to support drug discovery applications has led to the development of multiplexed capillary electrophoresis and multichannel microfluidic devices to characterize libraries of compounds and alleviate back
Autor:
Shelley J Coldiron, Jeremy R Kenseth
Publikováno v:
Current Opinion in Chemical Biology. 8:418-423
To fully realize the potential of combinatorial synthesis and high-throughput screening for increasing the efficiency of the drug discovery and development process, issues related to compound purity must be addressed. Impurities, often present after
Publikováno v:
Langmuir. 17:4105-4112
This paper investigates three different approaches to patterning proteins within ultrathin resist layers formed from self-assembled monolayers using scanning probe lithography (SPL) at the submicrometer length scale. The first approach uses a “nano
Autor:
Jeremy R. Kenseth, Gerald J. Small, Ryszard Jankowiak, George P. Casale, Scott D. Duhachek, Marc D. Porter
Publikováno v:
Analytical Chemistry. 72:3709-3716
A new direct readout methodology for detection and quantitation of fluorescent carcinogen-DNA adducts is described. It combines the binding specificity of an immobilized monoclonal antibody (MAb) with high-resolution, low-temperature fluorescence spe
Publikováno v:
Analytical Chemistry. 70:1233-1241
This paper combines the topographic imaging capability of the atomic force microscope (AFM) with a compositionally patterned array of immobilized antigenic rabbit IgG on gold as an approach to performing immunoassays. The substrates are composed of m
Autor:
John-Bruce D. Green, Vivian W. Jones, Jianhong Wang, Jeremy R. Kenseth, Mark T. McDermott, Marc D. Porter
Publikováno v:
Journal of the American Chemical Society. 119:12796-12799
This paper reports on the use of a scanning force microscope (SFM) for the tip-assisted base hydrolysis of an ester-terminated alkanethiolate monolayer on Au(111). We have found that contact imaging accelerates the base hydrolysis of a dithiobis(succ
Publikováno v:
ChemInform. 30
Autor:
Julia F. Ridpath, Karen M. Kwarta, Marc D. Porter, Jeremy R. Kenseth, Jeremy D. Driskell, John D. Neill
Publikováno v:
Combinatorial Materials Science
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc1c4addf6fb383d790139d5db858741
https://doi.org/10.1002/9780470140475.ch4
https://doi.org/10.1002/9780470140475.ch4