Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jeremy R. Hershfield"'
Autor:
Jeremy R. Hershfield, Seongjin Park, Tucker Maxson, Taekjip Ha, Nathan E. Schroeder, Kristen M. Flatt, Douglas A. Mitchell, Katie J. Molohon, Patricia M. Blair, James R. Doroghazi
Publikováno v:
ACS Infectious Diseases. 2:207-220
Plantazolicin (PZN) is a ribosomally synthesized and post-translationally modified natural product from Bacillus methylotrophicus FZB42 and Bacillus pumilus. Extensive tailoring to twelve of the fourteen amino acid residues in the mature natural prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d728a5922f7402ce54ad066166a5d448
https://doi.org/10.1021/acsinfecdis.5b00115
https://doi.org/10.1021/acsinfecdis.5b00115
Autor:
Stephanie Halasohoris, S. Ken Tanaka, Judith N. Steenbergen, Jeremy R. Hershfield, Lynda Miller
Publikováno v:
Antimicrobial Agents and Chemotherapy
The in vitro activity and in vivo efficacy of omadacycline (OMC) were evaluated against the causative pathogens of anthrax and plague, Bacillus anthracis and Yersinia pestis , respectively. MICs of OMC were determined by broth microdilution according
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4646c2af559008dc893e471e4317f65
http://europepmc.org/articles/PMC5404541
http://europepmc.org/articles/PMC5404541
Autor:
Lynda Miller, Patricia L. Worsham, Bret K. Purcell, Stephanie Halasohoris, Charles L. Marchand, Jeremy R. Hershfield, Henry S. Heine
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:1919-1921
In vitro susceptibilities to 45 antibiotics were determined for 30 genetically and geographically diverse strains of Yersinia pestis by the broth microdilution method at two temperatures, 28°C and 35°C, following Clinical and Laboratory Standards I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc00507f3523f24b02eac9223471bf9
https://doi.org/10.1128/aac.04548-14
https://doi.org/10.1128/aac.04548-14
Autor:
Jeremy R. Hershfield, Ajit Jadhav, Charles L. Marchand, Patricia M. Legler, Kelly L. Robertson, Xin Hu, Arthur M. Friedlander, Jaimee R. Compton, Anders Wallqvist, Dagmar H. Leary, Mohamed Diwan M. AbdulHameed
Publikováno v:
Journal of Medicinal Chemistry. 56:5275-5287
In this study, we describe novel inhibitors against Francisella tularensis SchuS4 FabI identified from structure-based in silico screening with integrated molecular dynamics simulations to account for induced fit of a flexible loop crucial for inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50953e0ceb34677b85820c448ac2418c
https://doi.org/10.1021/jm4001242
https://doi.org/10.1021/jm4001242
Autor:
Jeremy R. Hershfield, M. A. Aryan Namboodiri, Nagarajan Pattabiraman, Chikkathur N. Madhavarao
Publikováno v:
Brain Research. 1148:1-14
Mutations that result in near undetectable activity of aspartoacylase, which catalyzes the deacetylation of N-acetyl-l-aspartate, correlate with Canavan Disease, a neurodegenerative disorder usually fatal during childhood. The underlying biochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46453dbb5958e08667d1d4efe0853511
https://doi.org/10.1016/j.brainres.2007.02.069
https://doi.org/10.1016/j.brainres.2007.02.069
Autor:
Chikkathur N. Madhavarao, Jeremy R. Hershfield, M. A. Aryan Namboodiri, John R. Moffett, Peethambaran Arun
Publikováno v:
NeuroReport. 15:1167-1170
N-Acetylaspartylglutamate (NAAG) is a neuropeptide that is thought to modulate neurotransmitter release through pre-synaptic mGluR3 receptors. Despite years of research into NAAG biochemistry, almost nothing is known about NAAG biosynthesis. To date,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99daa6a33a2fcc3c730e6b291281323e
https://doi.org/10.1097/00001756-200405190-00017
https://doi.org/10.1097/00001756-200405190-00017
Autor:
Jeremy A. Miller, Elizabeth Wasbrough, Brandon Somerville, Floyd E. Romesberg, Stephanie Halasohoris, Jian Liu, Danielle Barrios Steed, Lynda Miller, Jeremy R. Hershfield
Publikováno v:
Antimicrobial agents and chemotherapy. 59(7)
Yersinia pestis is the etiologic agent of the plague. Reports of Y. pestis strains that are resistant to each of the currently approved first-line and prophylactic treatments point to the urgent need to develop novel antibiotics with activity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d10c9d19c90dd37de8707fff649877b
https://pubmed.ncbi.nlm.nih.gov/25896690
https://pubmed.ncbi.nlm.nih.gov/25896690
Autor:
Jeremy R. Hershfield, Katherine A. Hurley, Samandra T. Demons, Douglas B. Weibel, Victoria A. Heinrich
Publikováno v:
ACS medicinal chemistry letters. 6(4)
We performed a structure-activity relationship study of 2-((3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)amino)-2-(hydroxymethyl)propane-1,3-diol (DCAP), which is an antibacterial agent that disrupts the membrane potential and permeability of ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142c7e9e861ed4e8d3c2e095ae19d476
https://pubmed.ncbi.nlm.nih.gov/25941556
https://pubmed.ncbi.nlm.nih.gov/25941556
Autor:
Asha Potti, Jeremy R. Hershfield, Sreela Namboodiri, Batool F. Kirmani, Chikkathur N. Madhavarao, Raji Mathew, David M. Jacobowitz, John R. Moffett, Aryan M.A. Namboodiri, Peethambaran Arun
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9780387301716
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb6ec5d1e2e55e4d0fc6fac69366d4f4
https://doi.org/10.1007/0-387-30172-0_10
https://doi.org/10.1007/0-387-30172-0_10
Autor:
Jeremy R. Hershfield, Raji Mathew, Prasanth A. Sambhu, Chikkathur N. Madhavarao, Arun Peethambaran, John R. Moffett, Aryan M.A. Namboodiri
Publikováno v:
Molecular and cellular endocrinology. 252(1-2)
Canavan disease (CD) is an autosomal-recessive neurodegenerative disorder caused by inactivation of the enzyme aspartoacylase (ASPA, EC 3.5.1.15) due to mutations. ASPA releases acetate by deacetylation of N-acetylaspartate (NAA), a highly abundant a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e236fe652a5e41a80ca200a61768ed1f
https://pubmed.ncbi.nlm.nih.gov/16647192
https://pubmed.ncbi.nlm.nih.gov/16647192