Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Jeremy R. Everett"'
Autor:
Sunil Veeravalli, Dorsa Varshavi, Flora H. Scott, Dorna Varshavi, Frank S. Pullen, Kirill Veselkov, Ian R. Phillips, Jeremy R. Everett, Elizabeth A. Shephard
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
We previously showed that Fmo5−/− mice exhibit a lean phenotype and slower metabolic ageing. Their characteristics include lower plasma glucose and cholesterol, greater glucose tolerance and insulin sensitivity, and a reduction in age-related wei
Externí odkaz:
https://doaj.org/article/876d2d8e8e49435d902d309b10fb2e2a
Autor:
Anthony C. Dona, Michael Kyriakides, Flora Scott, Elizabeth A. Shephard, Dorsa Varshavi, Kirill Veselkov, Jeremy R. Everett
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 14, Iss C, Pp 135-153 (2016)
Metabonomics/metabolomics is an important science for the understanding of biological systems and the prediction of their behaviour, through the profiling of metabolites. Two technologies are routinely used in order to analyse metabolite profiles in
Externí odkaz:
https://doaj.org/article/a8fcb20adfea45aeaf5c79ae303b66db
Autor:
Dorsa Varshavi, Flora H. Scott, Dorna Varshavi, Sunil Veeravalli, Ian R. Phillips, Kirill Veselkov, Nicole Strittmatter, Zoltan Takats, Elizabeth A. Shephard, Jeremy R. Everett
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
It was recently demonstrated in mice that knockout of the flavin-containing monooxygenase 5 gene, Fmo5, slows metabolic ageing via pleiotropic effects. We have now used an NMR-based metabonomics approach to study the effects of ageing directly on the
Externí odkaz:
https://doaj.org/article/ce1b0b72cb444c9f87e5f4b0a1085222
Autor:
Jeremy R. Everett
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 13, Iss C, Pp 131-144 (2015)
A new paradigm is proposed for assessing confidence in the identification of known metabolites in metabonomics studies using NMR spectroscopy approaches. This new paradigm is based upon the analysis of the amount of metabolite identification informat
Externí odkaz:
https://doaj.org/article/1dcd71adc1a74ca59a30c2590ca35e0b
Autor:
Kirill Veselkov, Jeremy R. Everett, Hector C. Keun, Dorna Varshavi, Dorsa Varshavi, Nicola McCarthy
Publikováno v:
Metabolomics
Introduction KRAS was one of the earliest human oncogenes to be described and is one of the most commonly mutated genes in different human cancers, including colorectal cancer. Despite KRAS mutants being known driver mutations, KRAS has proved diffic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef4760c2e41829a72a4e9bd41da4bd9
Autor:
Ian Phillips, Sunil Veeravalli, Rafael Teixeira Freire, Elizabeth A. Shephard, Dorsa Varshavi, Jeremy R. Everett
Publikováno v:
Drug Metabolism and Disposition. 48:378-385
Taurine is one of the most abundant amino acids in mammalian tissues. It is obtained from the diet and by de novo synthesis from cysteic acid or hypotaurine. Despite the discovery in 1954 that the oxygenation of hypotaurine produces taurine, the iden
Autor:
Jeremy R, Everett
Publikováno v:
Handbook of experimental pharmacology. 260
Metabonomics, also known as metabolomics, is concerned with the study of metabolite profiles in humans, animals, plants and other systems in order to assess their health or other status and their responses to experimental interventions. Metabonomics
Understanding metabotype (multicomponent metabolic characteristics) variation can help to generate new diagnostic and prognostic biomarkers, as well as models, with potential to impact on patient management. We present a suite of conceptual approache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82864c5efd7c2aa6c549afc627a57047
Autor:
Rafael Teixeira Freire, Jeremy R. Everett, Ian Phillips, Sunil Veeravalli, Dorna Varshavi, Elizabeth A. Shephard
Taurine is one of the most abundant amino acids in mammalian tissues. It is obtained from the diet and byde novosynthesis, from cysteic acid or hypotaurine. Despite the discovery in 1954 that the oxygenation of hypotaurine produces taurine, the ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d28ca9cafeb870a0c8274168853f70
https://doi.org/10.1101/750273
https://doi.org/10.1101/750273
Autor:
Jeremy R. Everett
Drug discovery and development is a long, complex and expensive process that has suffered lapses in productivity recently. A variety of new sciences and technologies has been applied in order to improve its productivity, especially in the drug discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e37bf459daf3dad5660162993431700
https://doi.org/10.1016/b978-0-12-812293-8.00014-1
https://doi.org/10.1016/b978-0-12-812293-8.00014-1