Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Jeremy R Graff"'
Autor:
Anissa S H Chan, Adria Bykowski Jonas, Xiaohong Qiu, Nadine R Ottoson, Richard M Walsh, Keith B Gorden, Ben Harrison, Peter J Maimonis, Steven M Leonardo, Kathleen E Ertelt, Michael E Danielson, Kyle S Michel, Mariana Nelson, Jeremy R Graff, Myra L Patchen, Nandita Bose
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0165909 (2016)
Imprime PGG (Imprime), an intravenously-administered, soluble β-glucan, has shown compelling efficacy in multiple phase 2 clinical trials with tumor targeting or anti-angiogenic antibodies. Mechanistically, Imprime acts as pathogen-associated molecu
Externí odkaz:
https://doaj.org/article/357100ff914f42d797e55b32fe9e7a5d
Autor:
Blake A Jacobson, Saritha C Thumma, Joseph Jay-Dixon, Manish R Patel, K Dubear Kroening, Marian G Kratzke, Ryan G Etchison, Bruce W Konicek, Jeremy R Graff, Robert A Kratzke
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81669 (2013)
BACKGROUND: Aberrant cap-dependent translation is implicated in tumorigenesis in multiple tumor types including mesothelioma. In this study, disabling the eIF4F complex by targeting eIF4E with eIF4E-specific antisense oligonucleotide (4EASO) is asses
Externí odkaz:
https://doaj.org/article/1e96907a0d2d40609b463c257cacb5d9
Autor:
Anissa S. H. Chan, Takashi O. Kangas, Xiaohong Qiu, Mark T. Uhlik, Ross B. Fulton, Nadine R. Ottoson, Keith B. Gorden, Yumi Yokoyama, Michael E. Danielson, Trinda M. Jevne, Kyle S. Michel, Jeremy R. Graff, Nandita Bose
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Imprime PGG (Imprime) is in late-stage clinical development as a combinatorial agent with several therapeutic modalities. Here we present pre-clinical mechanistic data supportive of Imprime, a soluble yeast β-1,3/1,6-glucan pathogen-associated molec
Externí odkaz:
https://doaj.org/article/3ecab3a75dcc4fa29265f88741647ad9
Autor:
Xiang S. Ye, Yong Wang, Juan A. Velasco, Courtney Tate, James J. Starling, Louis F. Stancato, Chuan Shih, Susan E. Pratt, Stephen H. Parsons, Songqing Na, Denis McCann, Mary Mader, Enrique Jambrina, Jeremy R. Graff, Raymond Gilmour, Alfonso De Dios, Edward M. Chan, Harold B. Brooks, Nathan A. Brooks, Bryan D. Anderson, Robert M. Campbell
p38α mitogen-activated protein kinase (MAPK) is activated in cancer cells in response to environmental factors, oncogenic stress, radiation, and chemotherapy. p38α MAPK phosphorylates a number of substrates, including MAPKAP-K2 (MK2), and regulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22628225105d10e01b1823421dc49781
https://doi.org/10.1158/1535-7163.c.6536578.v1
https://doi.org/10.1158/1535-7163.c.6536578.v1
Autor:
Xiang S. Ye, Yong Wang, Juan A. Velasco, Courtney Tate, James J. Starling, Louis F. Stancato, Chuan Shih, Susan E. Pratt, Stephen H. Parsons, Songqing Na, Denis McCann, Mary Mader, Enrique Jambrina, Jeremy R. Graff, Raymond Gilmour, Alfonso De Dios, Edward M. Chan, Harold B. Brooks, Nathan A. Brooks, Bryan D. Anderson, Robert M. Campbell
PDF file - 43K, Effect of LY2228820 on MK2 phosphorylation in mouse peripheral blood mononuclear cells (PBMC) and from patients with multiple myeloma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22324d5e3fb3ac4e9a4d4c1e89f1bae3
https://doi.org/10.1158/1535-7163.22500817.v1
https://doi.org/10.1158/1535-7163.22500817.v1
Autor:
Xiang S. Ye, Yong Wang, Juan A. Velasco, Courtney Tate, James J. Starling, Louis F. Stancato, Chuan Shih, Susan E. Pratt, Stephen H. Parsons, Songqing Na, Denis McCann, Mary Mader, Enrique Jambrina, Jeremy R. Graff, Raymond Gilmour, Alfonso De Dios, Edward M. Chan, Harold B. Brooks, Nathan A. Brooks, Bryan D. Anderson, Robert M. Campbell
PDF file - 86K, Supplemental Table 1. Kinases where LY2228820 shows >1000-fold selectivity in vitro (p38 MAPK vs. other kinase).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32264138e74601170f5f533f626867e
https://doi.org/10.1158/1535-7163.22500811.v1
https://doi.org/10.1158/1535-7163.22500811.v1
Autor:
Xiang S. Ye, Yong Wang, Juan A. Velasco, Courtney Tate, James J. Starling, Louis F. Stancato, Chuan Shih, Susan E. Pratt, Stephen H. Parsons, Songqing Na, Denis McCann, Mary Mader, Enrique Jambrina, Jeremy R. Graff, Raymond Gilmour, Alfonso De Dios, Edward M. Chan, Harold B. Brooks, Nathan A. Brooks, Bryan D. Anderson, Robert M. Campbell
PDF file - 90K, shRNA silencing of p38a MAPK in U-87MG glioma (Westerns and xenograft tumor growth data).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d956222196f28eb3db5494e81e7cc02
https://doi.org/10.1158/1535-7163.22500814.v1
https://doi.org/10.1158/1535-7163.22500814.v1
Autor:
Julia H. Carter, Larry E. Douglass, Harry W. Carter, Louis F. Stancato, Blake L. Neubauer, James A. Deddens, Bernadette M. Hurst, Jonathan W. Koop, Bruce M. Colligan, Leslie H. Brail, Stephen H. Parsons, Ann M. McNulty, Michele S. Dowless, Chad A. Dumstorf, Rebecca L. Lynch, Bruce W. Konicek, Jeremy R. Graff
Elevated eukaryotic translation initiation factor 4E (eIF4E) function induces malignancy in experimental models by selectively enhancing translation of key malignancy-related mRNAs (c-myc and BCL-2). eIF4E activation may reflect increased eIF4E expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da8315499ca53caae5c20055af1113a
https://doi.org/10.1158/0008-5472.c.6499437
https://doi.org/10.1158/0008-5472.c.6499437
Autor:
Julia H. Carter, Larry E. Douglass, Harry W. Carter, Louis F. Stancato, Blake L. Neubauer, James A. Deddens, Bernadette M. Hurst, Jonathan W. Koop, Bruce M. Colligan, Leslie H. Brail, Stephen H. Parsons, Ann M. McNulty, Michele S. Dowless, Chad A. Dumstorf, Rebecca L. Lynch, Bruce W. Konicek, Jeremy R. Graff
Supplementary Table 1 from eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2041a3ff3b409c9d7acc6936c0d246a4
https://doi.org/10.1158/0008-5472.22380054
https://doi.org/10.1158/0008-5472.22380054
Autor:
Steven M. Leonardo, Ross B. Fulton, Kathryn A. Fraser, Mark T. Uhlik, Xiaohong Qiu, Jamie Lowe, Mark A. Matson, Keith B. Gorden, Lindsay R Jordan, Nadine R. Ottoson, Nandita Bose, Blaine Rathmann, Adria Jonas, Richard Walsh, Takashi O Kangas, Ben Harrison, Anissa S.H. Chan, Kathleen E. Ertelt, Jeremy R. Graff, Richard D. Huhn
Publikováno v:
The Journal of Immunology. 202:2945-2956
Imprime PGG (Imprime) is an i.v. administered, yeast β-1,3/1,6 glucan in clinical development with checkpoint inhibitors. Imprime-mediated innate immune activation requires immune complex formation with naturally occurring IgG anti-β glucan Abs (AB