Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Jeremy R Duvall"'
Autor:
Marek M Nagiec, Adam P Skepner, Joseph Negri, Michelle Eichhorn, Nicolas Kuperwasser, Eamon Comer, Giovanni Muncipinto, Aravind Subramanian, Clary Clish, Kiran Musunuru, Jeremy R Duvall, Michael Foley, Jose R Perez, Michelle A J Palmer
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120295 (2015)
Recent genome wide association studies have linked tribbles pseudokinase 1 (TRIB1) to the risk of coronary artery disease (CAD). Based on the observations that increased expression of TRIB1 reduces secretion of VLDL and is associated with lower plasm
Externí odkaz:
https://doaj.org/article/462e5962fcb24652928b7b20d53c53e5
Autor:
Jeremy R. Duvall, Raghida A. Bukhalid, Naniye M. Cetinbas, Kalli C. Catcott, Kelly Lancaster, Keith W. Bentley, Suzanna Clark, Susan Clardy, Scott D. Collins, Anouk Dirksen, Elizabeth Ditty, Bingfan Du, Eugene W. Kelleher, Travis Monnell, Marina Protopopova, Caitlin Routhier, Cheri Stevenson, Elena Ter-Ovanesyan, Joshua D. Thomas, Alex Uttard, Jason Wang, Phonphimon Wongthida, Ling Xu, Annika Yau, Jeffrey Zurita, Dorin Toader, Marc Damelin, Timothy B. Lowinger
Publikováno v:
Cancer Research. 82:3503-3503
We present here a novel therapeutic agent, XMT-2056, that results in robust anti-tumor activity mediated by an immune response through targeted delivery of a STING agonist to the tumor microenvironment. By leveraging an antibody-drug conjugate (ADC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0104b7acc0fcee8f20a6655acfc9a034
https://doi.org/10.1158/1538-7445.am2022-3503
https://doi.org/10.1158/1538-7445.am2022-3503
Autor:
Susan M. Clardy, Eugene W. Kelleher, Raghida A. Bukhalid, LiuLiang Qin, Rebecca Mosher, Timothy B. Lowinger, Dorin Toader, Joshua D. Thomas, Kalli C. Catcott, Pamela Shaw, Chen-Ni Chin, Kenneth Avocetien, Marc Damelin, Brian D. Jones, Kelly Slocum, Jeremy R. Duvall, Travis Monnell, Keith W. Bentley, Naniye Malli Cetinbas, Winnie Lee
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background STING pathway agonism has emerged as a potential therapeutic mechanism to stimulate an innate anti-tumor immune response. While in principle systemic administration of a STING agonist would have many therapeutic benefits, including the del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81256e4265903f4d896728e7189e96e3
https://doaj.org/article/b5031bee1db5458fb014131f0b1a8d8c
https://doaj.org/article/b5031bee1db5458fb014131f0b1a8d8c
Autor:
Timothy Eitas, Naniye Malli, Cheri A. Stevenson, Kelly Lancaster, Anouk Dirksen, Alex Uttard, Marc Damelin, Jeremy R. Duvall, Dorin Toader, Raghida A. Bukhalid, Joshua D. Thomas, Pamela Shaw, Keith W. Bentley, Phonphimon Wongthida, Kalli C. Catcott, Bingfan Du, Marina Protopopova, Rebecca Mosher, Timothy B. Lowinger, Eugene W. Kelleher
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundThe tumor microenvironment is a complex, multicellular system, composed not only of malignant cancer cells but also of a diversity of stromal cells including vascular cells, immune cells, and fibroblasts that support tumorigenesis. Antigens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4616d3e3455f17ac369fc5a3dc2fa5
https://doi.org/10.1136/jitc-2021-sitc2021.785
https://doi.org/10.1136/jitc-2021-sitc2021.785
Autor:
Naniye Malli Cetinbas, Pamela Shaw, Dorin Toader, Keith W. Bentley, Eoin Kelleher, Susan M. Clardy, Marc Damelin, Jeremy R. Duvall, Rebecca Mosher, Winnie Lee, Brian D. Jones, Kenneth Avocetien, Travis Monnell, Kelly Slocum, Raghida A. Bukhalid, Joshua D. Thomas, Timothy B. Lowinger, Kalli C. Catcott
Publikováno v:
Cancer Research. 81:1773-1773
STING pathway plays a critical role in inducing anti-tumor immunity by upregulating Type 1 Interferon (IFN) and IFN-stimulated genes within the tumor microenvironment in response to cytosolic nucleic acid ligands. Therefore, the STING pathway agonism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9908c2e672c4e4b79e304926c0b68f5d
https://doi.org/10.1158/1538-7445.am2021-1773
https://doi.org/10.1158/1538-7445.am2021-1773
Autor:
Kelly Slocum, Rebecca Mosher, Jeffrey Zurita, Kenneth Avocetien, Joshua D. Thomas, Timothy B. Lowinger, Kalli C. Catcott, Susan M. Clardy, Marc Damelin, Jeremy R. Duvall, Marina Protopopova, Naniye Malli Cetinbas, Scott D. Collins, Ling Xu, Keith W. Bentley, Brian D. Jones, Elena Ter-Ovanesyan, Eugene W. Kelleher, Timothy Eitas, Raghida A. Bukhalid, Dorin Toader, Liping Yang, Travis Monnell, Elizabeth Ditty, LiuLiang Qin, Winnie Lee, Pamela Shaw, Phonphimon Wongthida, Stephen Bradley
Publikováno v:
Cancer Research. 81:1738-1738
STING pathway agonism has emerged as a potential therapeutic mechanism to stimulate an innate anti-tumor immune response. However, the systemic administration of a free STING agonist may be limited by toxicity, and broad biodistribution may not be id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dd4080a98b5a36ec4e0e10f0f535b90
https://doi.org/10.1158/1538-7445.am2021-1738
https://doi.org/10.1158/1538-7445.am2021-1738
Autor:
Wenye Sun, Zhenmin He, Adel M. Naylor-Olsen, Deming Xu, Joseph P. Vacca, Leanne Bedard, Ashlee M. Earl, Christina Scherer, Abigail L. Manson, Maurice D. Lee, Diane M Rush, Mark E. Fitzgerald, Mingliang Zhang, Huisheng Xu, Michelle Palmer, Joshua A. Bittker, Michael Foley, Jean-Charles Marie, Jeremy R. Duvall, Giovanni Muncipinto
Publikováno v:
ACS Infectious Diseases. 3:349-359
In 2013, the Centers for Disease Control highlighted Clostridium difficile as an urgent threat for antibiotic-resistant infections, in part due to the emergence of highly virulent fluoroquinolone-resistant strains. Limited therapeutic options current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f791f91a622ab9ee165e311f645c00d1
https://doi.org/10.1021/acsinfecdis.6b00206
https://doi.org/10.1021/acsinfecdis.6b00206
Autor:
Rachel Fearns, Qin Yu, Michael Foley, Paul Robert Fleming, Jeremy R. Duvall, Barbara Ludeke, Christina Scherer, Carol A. Mulrooney, Michelle Palmer, Maurice D. Lee, Karthick Vishwanathan, Sarah M. McLeod, Lynn VerPlank, Sebastian T. Le Quement
Publikováno v:
Antiviral Research. 131:19-25
Respiratory syncytial virus (RSV) infections affect millions of children and adults every year. Despite the significant disease burden, there are currently no safe and effective vaccines or therapeutics. We employed a replicon-based high throughput s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa878efee1369c35a8f9d01d24cbc4d5
https://doi.org/10.1016/j.antiviral.2016.03.015
https://doi.org/10.1016/j.antiviral.2016.03.015
Autor:
Daniel E. Neafsey, Dyann F. Wirth, Jon Clardy, Arvind Sharma, Ping S. Lui, Anne-Marie Zeeman, Sean Eckley, Yvonne Van Gessel, Mathias Wawer, Matthias Marti, Elizabeth A. Winzeler, Elamaran Meibalan, Nobutaka Kato, Benito Munoz, Emily R. Derbyshire, Stuart L. Schreiber, Marshall L. Morningstar, Jeremy R. Duvall, Clemens H. M. Kocken, Eli L. Moss, Bennett C. Meier, Joshua A. Bittker, Vicky M. Avery, Manmohan Sharma, John E. Burke, Eamon Comer, Jacob A. McPhail, Maurice A. Itoe, Jessica Bastien, Nicolas M. B. Brancucci, Branko Mitasev, David Clarke, Timothy A. Lewis, Victoria C. Corey, Sandra Duffy, Tomoyo Sakata-Kato, Fabian Gusovsky, Sandra March, Takashi Yoshinaga, Gillian L. Dornan, Flaminia Catteruccia, Morgane Sayes, Emily Lund, Christina Scherer, Sangeeta N. Bhatia, Michael Foley, Amit Sharma, Amanda K. Lukens, Paul A. Clemons, Koen J. Dechering, Karin M. J. Koolen, Micah Maetani
Publikováno v:
Nature
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of action could be discovered using a diverse collection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7124959dd9190076f4edcf04f4cc1a3b
Autor:
Kalli C. Catcott, Kelly Slocum, Marina Protopopova, Liping Yang, Joshua D. Thomas, Mark Nazzaro, Scott D. Collins, Chen-Ni Chin, Dorin Toader, LiuLiang Qin, Rebecca Mosher, Ling Xu, Jeffrey Zurita, Kenneth Avocetien, Tyler Carter, Raghida A. Bukhalid, Elena Ter-Ovanesyan, Keith W. Bentley, Marc Damelin, Jeremy R. Duvall, Naniye Malli Cetinbas, Timothy Eitas, Brian D. Jones, Stephen Bradley, Pamela Shaw, Susan M. Clardy, Timothy B. Lowinger, Eugene W. Kelleher
Publikováno v:
Cancer Research. 80:6706-6706
STING pathway agonism has emerged as a potential therapeutic mechanism to stimulate an innate anti-tumor immune response. While in principle systemic administration of a STING agonist would have many therapeutic benefits, including the delivery of ST
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb8874b5832868b1dcd0fa515563fcc7
https://doi.org/10.1158/1538-7445.am2020-6706
https://doi.org/10.1158/1538-7445.am2020-6706