A genome-wide search for determinants of survival in 1926 patients with advanced colorectal cancer with follow-up in over 22,000 patients

Autor: Valentina Escott-Price, Jeremy Peter Cheadle, Victoria Gray, Christopher Wills, Yazhou He, Malcolm G. Dunlop, Daniel D. Buchanan, Steve Gallinger, Tim Maughan, Richard Kaplan, Katie Watts, Polly A. Newcomb, Philip J. Law, Matthew G. Summers, Steven R. Alberts, Amanda I. Phipps, Andrew T. Chan, Richard S. Houlston, Qian Shi, Loic Le Marchand, Ulrike Peters, Hannah West, Yi Lin, Nada Al-Tassan, Rish K. Pai

Publikováno v: Eur J Cancer

BACKGROUND: While genome-wide association studies (GWAS) have identified germline variants influencing the risk of developing colorectal cancer (CRC), there has been limited examination of the possible role of inherited variation as a determinant of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8366e9523dc53ab804ea32ebeff9f363
https://doi.org/10.1016/j.ejca.2021.09.047

Role for Nucleotide Excision Repair Gene Variants in Oxaliplatin-Induced Peripheral Neuropathy

Autor: Oliver Fleck, Jeremy Peter Cheadle, Rebecca Harris, Michael J. Wagner, Howard L. McLeod, Richard Adams, Tim Maughan, Richard Kaplan, Michelle Coffey, David Fisher, Hannah West, James Colley

Publikováno v: JCO precision oncology. 2

Purpose Oxaliplatin forms part of routine treatment of advanced colorectal cancer; however, it often causes severe peripheral neuropathy, resulting in treatment discontinuation. We sought to determine the molecular and cellular mechanism underlying t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9195367898bf25117221eb49ba005a
https://pubmed.ncbi.nlm.nih.gov/35135151

Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci

Autor: Fredrick R. Schumacher, Pekka Jousilahti, Antti-Pekka Sarin, Veikko Salomaa, Heikki Järvinen, Salma M. Wakil, Anna Lepistö, Jukka-Pekka Mecklin, Graham Casey, Jan Böhm, Tim Maughan, Ian Tomlinson, Ella Barclay, Lauri A. Aaltonen, Ulrika A. Hänninen, Harry Campbell, Niko Välimäki, Aung Ko Win, Alexandra E. Gylfe, David V. Conti, Tomas Tanskanen, Jeremy Peter Cheadle, Albert Tenesa, Nada Al-Tassan, Eivind Ness-Jensen, Linda van den Berg, David J. Kerr, Samuli Ripatti, Steve Gallinger, Daniel D. Buchanan, Claire Palles, Eero Pukkala, Elinor Bexe Lindskog, Rachel Kerr, Lynn Martin, Susan M. Farrington, Richard Kaplan, Kaisa Silander, Shelley Idziaszczyk, Andres Metspalu, Tatiana Cajuso, Mark A. Jenkins, Sari Tuupanen, Laura Renkonen-Sinisalo, Kristian Hveem, Brian F. Meyer, Mervi Aavikko, Polly A. Newcomb, Malcolm G. Dunlop, Aarno Palotie, Neeme Tõnisson, Kimmo Palin, Yvonne Wettergren, John L. Hopper, Giulia Orlando, Christopher Smith, Philip J. Law, Maria Timofeeva, Richard S. Houlston, Johanna Kondelin

Publikováno v: Tanskanen, T, van den Berg, L M, Välimäki, N, Aavikko, M, Ness-Jensen, E, Hveem, K, Wettergen, Y, Bexe Lindskog, E, Tonisson, N, Metspalu, A, Silander, K, Orlando, G, Law, P J, Tuupanen, S, Gylfe, A, Hanninen, U A, Cajuso, T, Kondelin, J, Sarin, A-P, Pukkala, E, Jousilahti, P, Salomaa, V, Ripatti, S, Palotie, A, Järvinen, H, Renkonen-Sinisalo, L, Lepisto, A, Bohm, J, Mecklin, J-P, Al-Tassan, N A, Palles, C, Martin, L, Barclay, E, Tenesa, A, Farrington, S, Timofeeva, M, Meyer, B F, Wakil, S M, Campbell, H, Smith, C G, Idziaszczyk, S, Maughan, T, Kaplan, R, Kerr, R, Kerr, D, Buchanan, D D, Win, A K, Hopper, J L, Jenkins, M C, Newcomb, P, Gallinger, S, Conti, D, Schumacher, F, Casey, G, Cheadle, J P, Dunlop, M, Tomlinson, I P M, Houlston, R S, Palin, K & Aaltonen, L A 2017, ' Genome-wide asociation study and meta-analysis in Northrn European populations replicate multiple colorectal cancer risk loci : GWAS and meta-analysis of CRC ', International Journal of Cancer, vol. 142, no. 3, pp. 540-546 . https://doi.org/10.1002/ijc.31076

Genome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer, but there remains unexplained variability in genetic risk. To identify new risk variants and to confirm reported associations, we conducted a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9574bee520a5afc6a67baf31a985e7
https://doi.org/10.1002/ijc.31076

Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer

Autor: Daniel D. Buchanan, Jussi Taipale, Lynn Martin, Tim Maughan, Susan M. Farrington, Ella Barclay, Rachel Kerr, David V. Conti, Aung Ko Win, Jeremy Peter Cheadle, Tomas Tanskanen, Shelley Idziaszczyk, Aarno Palotie, Kimmo Palin, Christopher Smith, Samuli Ripatti, Harri Rissanen, Heikki Järvinen, Mark A. Jenkins, David Jarvis, Brian F. Meyer, Jonathan S. Mitchell, Salma M. Wakil, Jaakko Kaprio, Ian Tomlinson, Noralane M. Lindor, Alexandra E. Gylfe, Laura Renkonen-Sinisalo, Eero Pukkala, Eevi Kaasinen, Richard S. Houlston, Claire Palles, Nada Al-Tassan, Richard Kaplan, Anna Lepistö, David J. Kerr, Polly A. Newcomb, Sari Tuupanen, Fred Schumacher, Antti-Pekka Sarin, Veikko Salomaa, Malcolm G. Dunlop, Lauri A. Aaltonen, Graham Casey, Johan G. Eriksson, S. Gallinger, Ulrika A. Hänninen, Pekka Jousilahti, Harry Campbell, Jan Böhm, Tatiana Cajuso, Philip J. Law, Paul Knekt, Maria Timofeeva, John L. Hopper, Johanna Kondelin, Jukka Pekka Meklin

Publikováno v: British Journal of Cancer
Jarvis, D, Mitchell, J S, Law, P J, Palin, K, Tuupanen, S, Gylfe, A, Hänninen, U A, Cajuso, T, Tanskanen, T, Kondelin, J, Kaasinen, E, Sarin, A-P, Kaprio, J, Eriksson, J G, Rissanen, H, Knekt, P, Pukkala, E, Jousilahti, P, Salomaa, V, Ripatti, S, Palotie, A, Järvinen, H, Renkonen-Sinisalo, L, Lepistö, A, Böhm, J, Meklin, J-P, Al-Tassan, N A, Palles, C, Martin, L, Barclay, E, Farrington, S M, Timofeeva, M N, Meyer, B F, Wakil, S M, Campbell, H, Smith, C G, Idziaszczyk, S, Maughan, T S, Kaplan, R, Kerr, R, Kerr, D, Buchanan, D D, Win, A K, Hopper, J L, Jenkins, M A, Lindor, N M, Newcomb, P A, Gallinger, S, Conti, D, Schumacher, F, Casey, G, Taipale, J, Aaltonen, L A, Cheadle, J P, Dunlop, M G, Tomlinson, I P & Houlston, R S 2016, ' Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer ', British Journal of Cancer . https://doi.org/10.1038/bjc.2016.188

Article
Background: Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a Mendelian rando

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15b0ef86c5f4fd05343ea582b8c305e
http://europepmc.org/articles/PMC4947703

Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer

Autor: Aarno Palotie, Mark A. Jenkins, Kimmo Palin, Paul Knekt, Harri Rissanen, Eero Pukkala, Tatiana Cajuso, Tim Maughan, Antti-Pekka Sarin, Michael N. Passarelli, Salma M. Wakil, Ian Tomlinson, David V. Conti, Laura Renkonen-Sinisalo, Pekka Jousilahti, Johan G. Eriksson, Fred Schumacher, Amit Sud, David J. Kerr, Nada Al-Tassan, Sari Tuupanen, Claire Palles, Samuli Ripatti, Polly A. Newcomb, Lauri A. Aaltonen, Richard Kaplan, Ulrika A. Hänninen, Harry Campbell, Henry Rodriguez-Broadbent, Maria Timofeeva, Veikko Salomaa, Susan M. Farrington, Noralane M. Lindor, Lynn Martin, Richard S. Houlston, Steven Gallinger, Johanna Kondelin, Jeremy Peter Cheadle, John L. Hopper, Graham Casey, Alexandra E. Gylfe, Eevi Kaasinen, Christopher Smith, Malcolm G. Dunlop, Rachel Kerr, Jane C. Figueiredo, Philip J. Law, Anna Lepistö, Jukka-Pekka Mecklin, Jan Böhm, Brian F. Meyer, Ella Barclay, Aung Ko Win, Tomas Tanskanen, Shelley Idziaszczyk, Daniel D. Buchanan

Publikováno v: Rodriguez-Broadbent, H, J. Law, P, Sud, A, Palin, K, Tuupanen, S, Gylfe, A, Hanninen, U A, Cajuso, T, Tanskanen, T, Kondelin, J, Kaasinen, E, Sarin, A-P, Ripatti, S, Eriksson, J G, Rissanen, H, Knekt, P, Pukkala, E, Jousilahti, P, Salomaa, V, Palotie, A, Renkonen-Sinisalo, L, Lepisto, A, Bohm, J, Mecklin, J-P, Al-Tassan, N A, Palles, C, Martin, L, Barclay, E, Farrington, S, Timofeeva, M N, Meyer, B F, Wakil, S M, Campbell, H, Smith, C G, Idziaszczyk, S, Maughan, T S, Kaplan, R, Kerr, R, Kerr, D, Passarelli, M N, Figueiredo, J C, Buchanan, D D, Win, A K, Hopper, J L, Jenkins, M A, Lindor, N M, Newcomb, P A, Gallinger, S, Conti, D, Schumacher, F, Casey, G, Aaltonen, L A, Cheadle, J P, Tomlinson, I, Dunlop, M & Houlston, R S 2017, ' Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer. ', International Journal of Cancer . https://doi.org/10.1002/ijc.30709

While elevated blood cholesterol has been associated with an increased risk of colorectal cancer (CRC) in observational studies, causality is uncertain. Here we apply a Mendelian randomisation (MR) analysis to examine the potential causal relationshi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba65fa984ff63d9af76c46992976007
https://ora.ox.ac.uk/objects/uuid:fac7b2b4-e22c-4eae-8652-00cb59e79b83