Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jeremy P. Springhorn"'
Autor:
Krista Johnson, Katherine S. Bowdish, Jeremy P. Springhorn, Yi Wang, Mark Renshaw, Xiao Su, Shana Frederickson, Lynette M. Smith, Peter Calveley, Bing Lin, Yamin Shen
Publikováno v:
Proceedings of the National Academy of Sciences. 103:14307-14312
By using rational design, antibody fragments (Fabs) that mimic thrombopoietin (TPO) were created. A peptide with cMpl receptor-binding capability was grafted into different complementarity-determining regions of a fully human Fab scaffold. Functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89538ee593496987aa70b59fcc06b5d1
https://doi.org/10.1073/pnas.0602658103
https://doi.org/10.1073/pnas.0602658103
Autor:
Stephen P. Squinto, Russell P. Rother, Jeremy P. Springhorn, Scott A. Rollins, William L. Fodor
Publikováno v:
Advanced Drug Delivery Reviews. 17:213-226
The use of retroviral-mediated gene transfer as an in vivo approach for the treatment of human disease has been limited by the inability of retroviral vectors to survive the host humoral immune system. The rapid inactivation of retroviruses that ensu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf257ba78f94e2f4546852ff29bae639
https://doi.org/10.1016/0169-409x(95)00054-b
https://doi.org/10.1016/0169-409x(95)00054-b
Publikováno v:
Transplantation. 60:1284-1292
The hyperacute rejection (HAR) of xenotransplanted organs is initiated by the deposition of natural antibodies on donor endothelium followed by the activation of the recipient complement system, which rapidly destroys the graft. Studies of the role o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9c0bb5da0c775d7b4f3e03e7710f8e6
https://doi.org/10.1097/00007890-199512000-00017
https://doi.org/10.1097/00007890-199512000-00017
Publikováno v:
In Vitro Cellular & Developmental Biology - Animal. 31:473-481
We have developed a novel isolation technique for harvesting human capillary endothelial cells. We compared the use of either Ulex Europaeus Agglutinin (UEA) lectin or anti-platelet endothelial cell adhesion molecule (PECAM) antibody conjugated to ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac81c6148bf0652a24e0648d3995ed99
https://doi.org/10.1007/bf02634261
https://doi.org/10.1007/bf02634261
Autor:
Jeremy P. Springhorn
Publikováno v:
Cold Spring Harbor protocols. 2011(5)
INTRODUCTIONThe protocol described below outlines a technique to isolate and maintain pure populations of human capillary endothelial cells using an active selection technique that targets the platelet endothelial cell adhesion molecule (PECAM or CD3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340b529f5e141055483a0ec92a662bed
https://pubmed.ncbi.nlm.nih.gov/21536770
https://pubmed.ncbi.nlm.nih.gov/21536770
Autor:
Conor Mullaney, Yi Wang, Krista Johnson, Eric D. Lombardini, Paul P. Tamburini, Jeremy P. Springhorn, Patrick H. Ney, Merriline M. Satyamitra, John Graves, Venkataraman Srinivasan, Jeffrey W. Hunter
Publikováno v:
Radiation research. 175(6)
Thrombopoietin (TPO) receptor agonists lacking sequence homology to TPO were designed by grafting a known peptide sequence into the hinge and/or kappa constant regions of a human anti-anthrax antibody. Some of these proteins were equipotent to TPO in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d87131d88e8200e91fa4af32c622ea
https://pubmed.ncbi.nlm.nih.gov/21476857
https://pubmed.ncbi.nlm.nih.gov/21476857
Autor:
C W Birks, Scott A. Rollins, Russell P. Rother, Eva Setter, Stephen P. Squinto, M S Sandrin, Jeremy P. Springhorn, William L. Fodor
Publikováno v:
The Journal of Experimental Medicine
Type C retroviruses endogenous to various nonprimate species can infect human cells in vitro, yet the transmission of these viruses to humans is restricted. This has been attributed to direct binding of the complement component C1q to the viral envel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ead2325d89c90827e5327398b89f41
https://pubmed.ncbi.nlm.nih.gov/7595205
https://pubmed.ncbi.nlm.nih.gov/7595205
Autor:
Jeremy P. Springhorn
Publikováno v:
Cold Spring Harbor Protocols. 2011:pdb.prot4537
INTRODUCTIONThis protocol outlines a technique to isolate human capillary endothelial cells from human abdominal wall adipose tissue. The relative lack of cell-type complexity within fat tissue makes it an attractive source of endothelial cells. In a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ac5a79390a9b8016fbd367a077899f
https://doi.org/10.1101/pdb.prot4537
https://doi.org/10.1101/pdb.prot4537
Publikováno v:
Journal of Molecular and Cellular Cardiology. 24:242
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93ee2a4fd837393675378a1e7d94e545
https://doi.org/10.1016/0022-2828(92)90751-k
https://doi.org/10.1016/0022-2828(92)90751-k
Publikováno v:
Journal of Molecular and Cellular Cardiology. 24:176
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2d747c9ff479b4c2fdb76619311984e
https://doi.org/10.1016/0022-2828(92)90554-d
https://doi.org/10.1016/0022-2828(92)90554-d