Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jeremy N. Stables"'
Autor:
Jeremy N. Stables, Robert Shaw, Peter Topley, Irene M. Leigh, Connie J. Sexton, A. T. Williams, Carol Lovegrove
Publikováno v:
Journal of General Virology. 76:3107-3112
Human papillomaviruses (HPVs) are important human pathogens associated with a range of epithelial neoplasia. The rising incidence of HPV infection and association of HPV with malignancy has led to increased interest in appropriate management of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634474d32ede114a42f59e4095cdfcee
https://doi.org/10.1099/0022-1317-76-12-3107
https://doi.org/10.1099/0022-1317-76-12-3107
Autor:
Jeremy N. Stables, Connie J. Sexton, Kenneth L. Powell, Irene M. Leigh, Lawrence Banks, Charlotte M. Proby, Harshad Navsaria
Publikováno v:
Journal of General Virology. 74:755-761
We have examined intrinsic and external factors that influence human papillomavirus type 16 (HPV-16)-mediated immortalization of oral keratinocytes. The efficiency with which HPV can immortalize human oral keratinocytes was quantified and a considera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0636b38e3a689927565639be9550ac
https://doi.org/10.1099/0022-1317-74-4-755
https://doi.org/10.1099/0022-1317-74-4-755
Autor:
Dagmar Alber, G. Stuart Cockerill, Jeremy N. Stables, Kenneth L. Powell, Verity C. L. Dowdell, Richard D. Kelsey, Sian K. Bithell, James Lumley, Ann Chubb, Robert Alan Harris, Robert C. Baxter, Elisa Henderson, Natasha Weerasekera, Joanna Budworth, Ian J Fraser, Lara J. Wilson, Malcolm Clive Carter, Sally J. Keegan
Publikováno v:
Journal of medicinal chemistry. 50(7)
Respiratory syncytial virus (RSV) is the cause of one-fifth of all lower respiratory tract infections worldwide and is increasingly being recognized as representing a serious threat to patient groups with poorly functioning or immature immune systems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27cc877fe8ac62cbc5c1e4b79f51be1
https://pubmed.ncbi.nlm.nih.gov/17341059
https://pubmed.ncbi.nlm.nih.gov/17341059
Autor:
David Spalding, Stuart Cockerill, Malcolm Clive Carter, Peter Topley, Lindy L. Thomsen, D. J. Hayes, Patrick M. Woollard, Jeremy N. Stables, Karen Affleck, Malcolm Willson, Colin Stubberfield, Robert D. Shaw, Amanda Jowett, Steve McKeown, Kathryn Jane Smith, Stephen Barry Guntrip
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(11)
Described herein is the design and synthesis of indazolylaminopyridopyrimidines and quinazolines as inhibitors of the class 1 tyrosine kinase receptor family. Data is presented for N(4)-(1-benzyl-1H-indazol-5-yl)-N(6),N(6)-dimethylpyrido[3,4-d]pyrimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48edb70e191bcbba4e0e927907dd7f9
https://pubmed.ncbi.nlm.nih.gov/11378364
https://pubmed.ncbi.nlm.nih.gov/11378364
Autor:
David L. Selwood, David Madge, David G. Brummell, Ian G. Charles, Sylvie Meillerais, Robert C. Glen, Marcel Kling, Mark A. Tatlock, Qian Liu, Karen Reynolds, Grant Wishart, Joanna Budworth, Kenneth L. Powell, Jeremy N. Stables, Patricia A. Fernandez, Maria C. Goggin, Richard O. Campbell, Guillaume E. Burtin, Chi-Kit Woo, Kerry A. Wheeler, Graham D. Spacey, Surinder S. Chana, Adrian J. Hobbs
Publikováno v:
Journal of medicinal chemistry. 44(1)
Database searching and compound screening identified 1-benzyl-3-(3-dimethylaminopropyloxy)-indazole (benzydamine, 3) as a potent activator of the nitric oxide receptor, soluble guanylate cyclase. A comprehensive structure-activity relationship study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf9a2fbf7680e57afd4057e7b9a213a
https://pubmed.ncbi.nlm.nih.gov/11141091
https://pubmed.ncbi.nlm.nih.gov/11141091
Autor:
D. J. Hayes, David L. Selwood, Alan B. O'dowd, Jeremy N. Stables, John C.W. Comley, Mike J. Rees
Publikováno v:
Molecular and biochemical parasitology. 38(2)
The effects of two novel analogues of antimycin A (BWA466C and BWA728C) on filarial oxygen consumption, energy generation and survival were investigated in vitro. For comparison, incubations were performed with a range of mitochondrial respiration in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4573a52143d1ef8d462968b9911bef
https://pubmed.ncbi.nlm.nih.gov/2325703
https://pubmed.ncbi.nlm.nih.gov/2325703
Autor:
David J. Livingstone, Valerie S. Rose, Alan B. O'dowd, David L. Selwood, Peter K. Jackson, Jeremy N. Stables, Karamjit S. Jandu, John C.W. Comley, Hudson Alan Thomas
Publikováno v:
Journal of medicinal chemistry. 33(1)
The structure-activity relationships of a series of novel antifilarial antimycin A1 analogues have been investigated by using computational chemistry and multivariate statistical techniques. The physiochemical descriptors calculated in this way conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274c44027597a3ff6accecd3ea1084a3
https://pubmed.ncbi.nlm.nih.gov/2296013
https://pubmed.ncbi.nlm.nih.gov/2296013
Autor:
Elisa A. Henderson, Dagmar G. Alber, Robert C. Baxter, Sian K. Bithell, Joanna Budworth, Malcolm C. Carter, Ann Chubb, G. Stuart Cockerill, Verity C. L. Dowdell, Ian J. Fraser, Robert A. Harris, Sally J. Keegan, Richard D. Kelsey, James A. Lumley, Jeremy N. Stables, Natasha Weerasekera, Lara J. Wilson, Kenneth L. Powell
Publikováno v:
Journal of Medicinal Chemistry; Apr2007, Vol. 50 Issue 7, p1685-1692, 8p
Publikováno v:
Molecular and Biochemical Parasitology. 19:265-271
Adult Brugia pahangi and Dipetalonema viteae utilise a percentage of absorbed glucose (ca. 15%) in the formation of the disaccharide trehalose [8]. This paper reports an investigation, employing 13C-NMR techniques, of the utilisation of trehalose by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e2e8965c52e42cff95478eaa321305
https://doi.org/10.1016/0166-6851(86)90009-5
https://doi.org/10.1016/0166-6851(86)90009-5
Publikováno v:
Molecular and biochemical parasitology. 18(2)
This study followed the metabolism of [13C]glucose under anaerobic and aerobic conditions in the adult filarial nematodes Brugia pahangi and Dipetalonema viteae using non-invasive 13C nuclear magnetic resonance techniques. Adult B. pahangi and D. vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b03a3c3cc950ba0790c8b0ec2e866e
https://pubmed.ncbi.nlm.nih.gov/3960053
https://pubmed.ncbi.nlm.nih.gov/3960053