Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Jeremy N Burrows"'
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009384 (2021)
It is estimated that more than 1 billion people across the world are affected by a neglected tropical disease (NTD) that requires medical intervention. These diseases tend to afflict people in areas with high rates of poverty and cost economies billi
Externí odkaz:
https://doaj.org/article/1c007e1d50c645f39fc22e11900307c2
Autor:
Kirandeep Samby, Hanu Ramachandruni, Jaya Banerji, Jeremy N Burrows, Penny Grewal Daumerie, Rob A.M. Hooft van Huijsduijnen, Stephan Duparc, Timothy N.C. Wells
Publikováno v:
Journal of Vector Borne Diseases, Vol 56, Iss 1, Pp 15-24 (2019)
The global fight against malaria requires continual development of new tools. Collaborations in India have played a key role in MMV’s partnerships to discover, develop and deliver new medicines. Over the last decade, India has become a focal point
Externí odkaz:
https://doaj.org/article/70cb6f3d29644a3ea1ac654f654e3f2b
Autor:
Reagan M. Mogire, Silviane A. Miruka, Dennis W. Juma, Case W. McNamara, Ben Andagalu, Jeremy N. Burrows, Elodie Chenu, James Duffy, Bernhards R. Ogutu, Hoseah M. Akala
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Drug discovery is an intricate and costly process. Repurposing existing drugs and active compounds offers a viable pathway to develop new therapies for various diseases. By leveraging publicly available biomedical information, it is possible
Externí odkaz:
https://doaj.org/article/9abd7be432b44ac9ad401606323a2e80
Autor:
Thomas Spangenberg, Jeremy N Burrows, Paul Kowalczyk, Simon McDonald, Timothy N C Wells, Paul Willis
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e62906 (2013)
Historically, one of the key problems in neglected disease drug discovery has been identifying new and interesting chemotypes. Phenotypic screening of the malaria parasite, Plasmodium falciparum has yielded almost 30,000 submicromolar hits in recent
Externí odkaz:
https://doaj.org/article/86732646cc42429a92be6409345df320
Autor:
Laura M Sanz, Benigno Crespo, Cristina De-Cózar, Xavier C Ding, Jose L Llergo, Jeremy N Burrows, Jose F García-Bustos, Francisco-Javier Gamo
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30949 (2012)
Chemotherapy is still the cornerstone for malaria control. Developing drugs against Plasmodium parasites and monitoring their efficacy requires methods to accurately determine the parasite killing rate in response to treatment. Commonly used techniqu
Externí odkaz:
https://doaj.org/article/f895316721144aa198f0982b7d046429
Autor:
Nada Abla, Eleanor Howgate, Karen Rowland‐Yeo, Maurice Dickins, Mackenzie C. Bergagnini‐Kolev, Kuan‐Fu Chen, Savannah McFeely, Jennifer J. Bonner, Laura G. A. Santos, Nathalie Gobeau, Howard Burt, Zoe Barter, Hannah M. Jones, David Wesche, Susan A. Charman, Jörg J. Möhrle, Jeremy N. Burrows, Lisa M. Almond
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 9, Pp 1335-1346 (2023)
Abstract As part of a collaboration between Medicines for Malaria Venture (MMV), Certara UK and Monash University, physiologically‐based pharmacokinetic (PBPK) models were developed for 20 antimalarials, using data obtained from standardized in vit
Externí odkaz:
https://doaj.org/article/9ba16da913cf47668851fe83f723f4b5
Autor:
Camilla Valente Pires, Debora Cassandra, Shulin Xu, Benoit Laleu, Jeremy N. Burrows, John H. Adams
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Malaria parasites have adaptive mechanisms to modulate their intracellular redox status to tolerate the enhanced oxidizing effects created by malaria fever, hemoglobinopathies and other stress conditions, including antimalaria drugs. Emergin
Externí odkaz:
https://doaj.org/article/76188a7284fa440fbb34f23d01b7d90d
Autor:
Annabelle Walz, Maëlle Duffey, Ghaith Aljayyoussi, Sibylle Sax, Didier Leroy, Dominique Besson, Jeremy N. Burrows, Mohammed H. Cherkaoui-Rbati, Nathalie Gobeau, Marie-Anne Westwood, Christoph Siethoff, Francisco-Javier Gamo, Pascal Mäser, Sergio Wittlin
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 163 (2023)
With artemisinin-resistant Plasmodium falciparum parasites emerging in Africa, the need for new antimalarial chemotypes is persistently high. The ideal pharmacodynamic parameters of a candidate drug are a rapid onset of action and a fast rate of para
Externí odkaz:
https://doaj.org/article/ed61e47142b2471096b9a830abacea17
Autor:
Martin A. Lowe, Alvaro Cardenas, Jean-Pierre Valentin, Zhaoning Zhu, Jan Abendroth, Jose L. Castro, Reiner Class, Annie Delaunois, Renaud Fleurance, Helga Gerets, Vitalina Gryshkova, Lloyd King, Donald D. Lorimer, Malcolm MacCoss, Julian H. Rowley, Marie-Luce Rosseels, Leandro Royer, Richard D. Taylor, Melanie Wong, Oliver Zaccheo, Vishal P. Chavan, Gokul A. Ghule, Bapusaheb K. Tapkir, Jeremy N. Burrows, Maëlle Duffey, Matthias Rottmann, Sergio Wittlin, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Josefine Striepen, Kate J. Fairhurst, Tomas Yeo, David A. Fidock, Alan F. Cowman, Paola Favuzza, Benigno Crespo-Fernandez, Francisco Javier Gamo, Daniel E. Goldberg, Dominique Soldati-Favre, Benoît Laleu, Teresa de Haro
Publikováno v:
Journal of Medicinal Chemistry. 65:14121-14143
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec94f8ff9ea22504d996591d0d9a232d
https://doi.org/10.1021/acs.jmedchem.2c01336
https://doi.org/10.1021/acs.jmedchem.2c01336
Autor:
Katherine T. Andrews, Gillian M. Fisher, Meaghan Firmin, Andris J. Liepa, Tony Wilson, James Gardiner, Yacine Mohri, Anjana Rai, Andrew K. Davey, Antoine Masurier, Alix Delion, Alexandos A. Mouratidis, Oliver Hutt, Jeremy N. Burrows, John H. Ryan, Andrew G. Riches, Tina S. Skinner-Adams
To achieve malaria eradication, new preventative agents that act differently to front-line treatment drugs are needed. To identify potential chemoprevention starting points we screened a sub-set of the CSIRO Australia Compound Collection for compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5f71c16c50f3313b0dd97d54fc96a3e
https://doi.org/10.1101/2023.03.09.531229
https://doi.org/10.1101/2023.03.09.531229
