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of 6
pro vyhledávání: '"Jeremy Muhlich"'
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 2, Pp 1-26 (2023)
Abstract BRAF is prototypical of oncogenes that can be targeted therapeutically and the treatment of BRAFV600E melanomas with RAF and MEK inhibitors results in rapid tumor regression. However, drug‐induced rewiring generates a drug adapted state th
Externí odkaz:
https://doaj.org/article/69084d89f94441bbac55f795548a3834
Autor:
Simon Warchol, Robert Krueger, Ajit Johnson Nirmal, Giorgio Gaglia, Jared Jessup, Cecily C. Ritch, John Hoffer, Jeremy Muhlich, Megan L. Burger, Tyler Jacks, Sandro Santagata, Peter K. Sorger, Hanspeter Pfister
Publikováno v:
IEEE Trans Vis Comput Graph
New highly-multiplexed imaging technologies have enabled the study of tissues in unprecedented detail. These methods are increasingly being applied to understand how cancer cells and immune response change during tumor development, progression, and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041acc686b30ac578d34dd9e0f4315ef
https://pubmed.ncbi.nlm.nih.gov/36170403
https://pubmed.ncbi.nlm.nih.gov/36170403
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance
BRAFV600E is prototypical of oncogenic mutations that can be targeted therapeutically and treatment of BRAF-mutant melanomas with RAF and MEK inhibitors results in rapid tumor regression. However, drug-induced rewiring causes BRAFV600E melanoma cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1889ca782ed18320e14d2f41560555a2
https://doi.org/10.1101/2022.02.17.480899
https://doi.org/10.1101/2022.02.17.480899
Autor:
Adam J. Taylor, Milen Nikolov, Ino de Brujin, Jeremy Muhlich, Mialy De Felice, Artem Sokolov, Denis Schapiro, Peter Sorger, Julie Bletz, Nikolaus Schultz, Vésteinn Thorsson, James Eddy, Ethan Cerami
Publikováno v:
Cancer Research. 82:2131-2131
The Human Tumor Atlas Network (HTAN) is a National Cancer Institute (NCI) Cancer Moonshot Initiative to generate three-dimensional molecular and spatial atlases of diverse human tumors and characterize crucial transitions in cancer progression and tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26b4c9ce7208a8cf7ee669b025f66afe
https://doi.org/10.1158/1538-7445.am2022-2131
https://doi.org/10.1158/1538-7445.am2022-2131
Autor:
Steven P. Nilsen, M. Lora D. L. M. Ong, Jeremy Muhlich, Jay Copeland, Neal Gliksman, Jerrold R. Turner
High-throughput, multiplex slide-scanning technologies have become widely-used. Advantages include the ability to archive digital copies of slides, review slides as teams using virtual microscope software, and standardize analytical approaches. One b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5bdd3da618746cc48c331159c26d5cf
https://doi.org/10.17504/protocols.io.bbitiken
https://doi.org/10.17504/protocols.io.bbitiken
Autor:
Julio Saez-Rodriguez, Arthur Goldsipe, Jeremy Muhlich, Leonidas G. Alexopoulos, Bjorn Millard, Douglas A. Lauffenburger, Peter K. Sorger
Publikováno v:
Bioinformatics. Mar2008, Vol. 24 Issue 6, p840-840. 1p.