Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jeremy Mottram"'
Publikováno v:
Bio-Protocol, Vol 12, Iss 21 (2022)
Ubiquitination is a post-translational modification conserved across eukaryotic species. It contributes to a variety of regulatory pathways, including proteasomal degradation, DNA repair, and cellular differentiation. The ubiquitination of substrate
Externí odkaz:
https://doaj.org/article/af110d8aaedd46bb9ace42bb07371454
Autor:
Helen Ashwin, Karin Seifert, Sarah Forrester, Najmeeyah Brown, Sandy MacDonald, Sally James, Dimitris Lagos, Jon Timmis, Jeremy Mottram, Simon L. Croft, Paul M. Kaye
Publikováno v:
Wellcome Open Research, Vol 3 (2018)
Background: Human visceral leishmaniasis, caused by infection with Leishmania donovani or L. infantum, is a potentially fatal disease affecting 50,000-90,000 people yearly in 75 disease endemic countries, with more than 20,000 deaths reported. Experi
Externí odkaz:
https://doaj.org/article/8266bf4fdd7b40bb9ced167a047ba2bd
Publikováno v:
Europe PubMed Central
Leishmania mexicana mutants lacking cysteine proteinase genes cpa (delta cpa), cpb (delta cpb), or both cpa and cpb (delta cpa/cpb) have been generated by targeted gene disruption. Delta cpa mutants produce a disease phenotype in BALB/c mice close to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0834b1e26338bdfa35e837962f02c194
https://pubmed.ncbi.nlm.nih.gov/9862710
https://pubmed.ncbi.nlm.nih.gov/9862710
Trypanosomes cause medically and economically severe diseases such as Sleeping Sickness and Chagas'Disease in humans and Nagana in cattle. They are also inherently interesting scientifically, being single-cell eukaryotes under constant, strong divers
Publikováno v:
Europe PubMed Central
The p34CDC2 protein kinase is a key component in the regulation of the eukaryotic cell cycle. We have isolated from the protozoan parasite Leishmania mexicana mexicana a CDC2-related kinase gene (Lmmcrk1) encoding a 34-kDa protein kinase (lmmCRK1) wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3369d92960a1b9eaea2056ce026af2f3
https://pubmed.ncbi.nlm.nih.gov/8407941
https://pubmed.ncbi.nlm.nih.gov/8407941
Publikováno v:
Europe PubMed Central
In Trypanosoma brucei the U snRNA B gene (J. C. Mottram, K. L. Perry, P. M. Lizardi, R. Lührmann, N. Agabian, and R. G. Nelson (1989) Mol. Cell. Biol. 9, 1212-1223) is very tightly linked with other small RNA genes coding for tRNA(ACGArg), tRNA(CUUL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::180a2adbf1b43f8ac9f20005357159cd
https://pubmed.ncbi.nlm.nih.gov/1717447
https://pubmed.ncbi.nlm.nih.gov/1717447
Publikováno v:
Europe PubMed Central
Trypanosomes use trans splicing to place a common 39-nucleotide spliced-leader sequence on the 5' ends of all of their mRNAs. To identify likely participants in this reaction, we used antiserum directed against the characteristic U RNA 2,2,7-trimethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0df4735bcd4f25e4307115dee6267a
https://doi.org/10.1128/mcb.9.3.1212-1223.1989
https://doi.org/10.1128/mcb.9.3.1212-1223.1989
Publikováno v:
Europe PubMed Central
Previous studies have shown that CRK3 protein kinase of Leishmania mexicana is a potential drug target. Therefore, the aim of this study was to provide an active protein kinase for chemical inhibitors testing. A system was developed to express and af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cae70a19f70efdfcb69fa548412cde1a
http://europepmc.org/abstract/med/23104649
http://europepmc.org/abstract/med/23104649