Výsledky vyhledávání - "Jeremy M. Zimbron"

Insights into the antiproliferative mechanism of (C^N)-chelated half-sandwich iridium complexes

Autor: Annie Munier, Serge Thorimbert, Michèle Salmain, Lise-Marie Chamoreau, Joëlle Sobczak-Thépot, Jeremy M. Zimbron, Anthi Karaiskou, Candice Botuha, Robin Ramos

Publikováno v: Dalton Transactions
Dalton Transactions, Royal Society of Chemistry, In press, ⟨10.1039/D0DT03414B⟩

International audience; Transition metal-based anticancer compounds, as an alternative to platinum derivatives, are raising scientific interest as they may present distinct although poorly understood mechanisms of action. We used a structure–activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3442af608a8642cb746812939a9d5f0c
https://pubmed.ncbi.nlm.nih.gov/33226042

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pH‐Sensitive Poly(ethylene glycol)/Poly(ethoxyethyl glycidyl ether) Block Copolymers: Synthesis, Characterization, Encapsulation, and Delivery of a Hydrophobic Drug

Autor: Michèle Salmain, Nicolas Illy, Philippe Guégan, Vincent Corcé, Vincent Molinié, Jéril Degrouard, Mélanie Labourel, Guillaume Tresset, Jeremy M. Zimbron

Publikováno v: Macromolecular Chemistry and Physics
Macromolecular Chemistry and Physics, Wiley-VCH Verlag, 2019, 220 (16), pp.1900210. ⟨10.1002/macp.201900210⟩

International audience; Curcumin is a natural polyphenolic compound known for its numerous pharmacological properties. However, its low water solubility and instability at neutral pH are serious drawbacks preventing its use as an oral drug. Well‐de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81447d6508ff5b70484fc1232cbca85
https://hal.sorbonne-universite.fr/hal-02282220

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Noyori–Ikariya catalyst supported on tetra-arylphosphonium salt for asymmetric transfer hydrogenation in water

Autor: Maxime Dauphinais, Jeremy M. Zimbron, André B. Charette

Publikováno v: Green Chemistry. 17:3255-3259

A straightforward synthesis of a tetraarylphosphonium (TAP)-supported Noyori–Ikariya catalyst is described. The TAP-supported ruthenium precatalyst provided good conversions and high enantioselectivities for the asymmetric transfer hydrogenation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9ab833bdcb8df56c8f70c362a44d01a
https://doi.org/10.1039/c5gc00086f

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Synthesis, Photophysical Properties, and Living Cell Imaging of Theranostic Half-Sandwich Iridium-4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) Dyads

Autor: Blaise Gatin-Fraudet, Kevin Passador, Damian Plażuk, Claude-Marie Bachelet, Lise-Marie Chamoreau, Serge Thorimbert, Michèle Salmain, Jeremy M. Zimbron, Candice Botuha

Publikováno v: Organometallics
Organometallics, American Chemical Society, 2017, 36 (18), pp.3435-3442. ⟨10.1021/acs.organomet.7b00250⟩
Organometallics, 2017, 36 (18), pp.3435-3442. ⟨10.1021/acs.organomet.7b00250⟩

International audience; We report the synthesis, characterization, and photophysical properties of two new cyclometalated half-sandwich iridium(III) complexes having the general formula [(η5-Cp*)Ir(ppy)Z]PF6 where η5-Cp* = pentamethylcyclopentadien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e26b79245a1adfb250be0c8f2189e3
https://hal.sorbonne-universite.fr/hal-01537852/document

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Expanding the Chemical Diversity in Artificial Imine Reductases Based on the Biotin-Streptavidin Technology

Autor: Thomas R. Ward, Valentin Köhler, Tommaso Quinto, Albert Morina, Jeremy M. Zimbron, Fabian Schwizer

Publikováno v: ChemCatChem. 6:1010-1014

We report on the optimization of an artificial imine reductase based on the biotin-streptavidin technology. With the aim of rapidly generating chemical diversity, a novel strategy for the formation and evaluation of biotinylated complexes is disclose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4dd145db57ac88952b731b81ca7c726
https://doi.org/10.1002/cctc.201300825

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Chemo-Genetic Optimization of DNA Recognition by Metallodrugs using a Presenter-Protein Strategy

Autor: Therese Wohlschlager, Alessia Sardo, Tilman Schirmer, Tillmann Heinisch, Claudia Massa, Jeremy M. Zimbron, Julieta Gradinaru, Thomas R. Ward, Marc Creus

Publikováno v: Chemistry

The mode of action of precious metal anticancer metallodrugs is generally believed to involve DNA as a target. However, the poor specificity of such drugs often requires high doses and leads to undesirable side-effects. With the aim of improving the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159a399dbd104d45aed07b3a78b674e8
https://doi.org/10.1002/chem.201001573

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A Dual Anchoring Strategy for the Localization and Activation of Artificial Metalloenzymes Based on the Biotin-Streptavidin Technology

Autor: Maurus Schmid, Jeremy M. Zimbron, Tillmann Heinisch, Thomas R. Ward, Didier R. Hamels, Elisa S. Nogueira, Tilman Schirmer

Artificial metalloenzymes result from anchoring an active catalyst within a protein environment. Toward this goal, various localization strategies have been pursued: covalent, supramolecular, or dative anchoring. Herein we show that introduction of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea3cf5db5c6797dc74caea75c16fbeb

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