Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jeremy M. Rock"'
Autor:
Monique E. Theriault, Davide Pisu, Kaley M. Wilburn, Gabrielle Lê-Bury, Case W. MacNamara, H. Michael Petrassi, Melissa Love, Jeremy M. Rock, Brian C. VanderVen, David G. Russell
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
An inhibitor of Mycobacterium tuberculosis (Mtb) survival acts as an iron chelator, demonstrating that iron deprivation alters Mtb cholesterol and central carbon metabolism.
Externí odkaz:
https://doaj.org/article/ab9219f46bfa49c894494067d5bb497b
Autor:
Nicholas C. Poulton, Jeremy M. Rock
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Tuberculosis (TB) is among the most difficult infections to treat, requiring several months of multidrug therapy to produce a durable cure. The reasons necessitating long treatment times are complex and multifactorial. However, one major difficulty o
Externí odkaz:
https://doaj.org/article/bf094f16b5034145aaa5bbcd70bf90d1
Autor:
Katherine S. Wetzel, Carlos A. Guerrero-Bustamante, Rebekah M. Dedrick, Ching-Chung Ko, Krista G. Freeman, Haley G. Aull, Ashley M. Divens, Jeremy M. Rock, Kira M. Zack, Graham F. Hatfull
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
Abstract Genome engineering of bacteriophages provides opportunities for precise genetic dissection and for numerous phage applications including therapy. However, few methods are available for facile construction of unmarked precise deletions, inser
Externí odkaz:
https://doaj.org/article/b1b89e6a2de841798e39f54d739bc4c6
Autor:
Gregory H. Babunovic, Michael A. DeJesus, Barbara Bosch, Michael R. Chase, Thibault Barbier, Amy K. Dickey, Bryan D. Bryson, Jeremy M. Rock, Sarah M. Fortune
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Macrophages are a protective replicative niche for Mycobacterium tuberculosis (Mtb) but can kill the infecting bacterium when appropriately activated. To identify mechanisms of clearance, we compared levels of bacterial restriction by human
Externí odkaz:
https://doaj.org/article/92eb1a5d9c3648df89b29579cd8c4859
Autor:
Allison Fay, Nadine Czudnochowski, Jeremy M. Rock, Jeffrey R. Johnson, Nevan J. Krogan, Oren Rosenberg, Michael S. Glickman
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Mycolic acids are the signature lipid of mycobacteria and constitute an important physical component of the cell wall, a target of mycobacterium-specific antibiotics and a mediator of Mycobacterium tuberculosis pathogenesis. Mycolic acids ar
Externí odkaz:
https://doaj.org/article/0c61a1c4c8a74e1dae2c681040bf409e
Autor:
Xiangwu Ju, Shuqi Li, Ruby Froom, Ling Wang, Mirjana Lilic, Elizabeth A. Campbell, Jeremy M. Rock, Shixin Liu
Publikováno v:
bioRxiv
Mycobacterium tuberculosis(Mtb) is a bacterial pathogen that causes tuberculosis, an infectious disease that inflicts major health and economic costs around the world1. Mtb encounters a diversity of environments during its lifecycle, and responds to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea28363027a23d26f470832fb89b4f8d
https://doi.org/10.1101/2023.03.10.532058
https://doi.org/10.1101/2023.03.10.532058
Autor:
Shuqi Li, Nicholas C. Poulton, Jesseon S. Chang, Zachary A. Azadian, Michael A. DeJesus, Nadine Ruecker, Matthew D. Zimmerman, Kathryn A. Eckartt, Barbara Bosch, Curtis A. Engelhart, Daniel F. Sullivan, Martin Gengenbacher, Véronique A. Dartois, Dirk Schnappinger, Jeremy M. Rock
Publikováno v:
Nature Microbiology. 7:766-779
Mycobacterium tuberculosis (Mtb) infection is notoriously difficult to treat. Treatment efficacy is limited by Mtb’s intrinsic drug resistance, as well as its ability to evolve acquired resistance to all antituberculars in clinical use. A deeper un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f52c73c301fb7cfa3028e65af38ad33
https://doi.org/10.1038/s41564-022-01130-y
https://doi.org/10.1038/s41564-022-01130-y
Publikováno v:
Antimicrob Agents Chemother
Tuberculosis (TB) is the leading cause of death from any bacterial infection, causing 1.5 million deaths worldwide each year. Due to the emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) there have been significant efforts aimed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57002db8e3a3f552ccf5c85e4d876f8a
https://europepmc.org/articles/PMC9487612/
https://europepmc.org/articles/PMC9487612/
Autor:
Felipe B. d’Andrea, Nicholas C. Poulton, Ruby Froom, Kayan Tam, Elizabeth A. Campbell, Jeremy M. Rock
Publikováno v:
Science Advances. 8
The Clp protease system is a promising, noncanonical drug target against Mycobacterium tuberculosis (Mtb). Unlike in Escherichia coli , the Mtb Clp protease consists of two distinct proteolytic subunits, ClpP1 and ClpP2, which hydrolyze substrates de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52a298020d1bb0f5feb1e83814c410e9
https://doi.org/10.1126/sciadv.abn7943
https://doi.org/10.1126/sciadv.abn7943
Autor:
Felipe B, d'Andrea, Nicholas C, Poulton, Ruby, Froom, Kayan, Tam, Elizabeth A, Campbell, Jeremy M, Rock
Publikováno v:
Science advances. 8(18)
The Clp protease system is a promising, noncanonical drug target against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26e2088c9128a5bf99b3e77b1cd54ddc
https://pubmed.ncbi.nlm.nih.gov/35507665
https://pubmed.ncbi.nlm.nih.gov/35507665