Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jeremy M. Richter"'
Autor:
Phil S. Baran, Narendra B. Ambhaikar, Carlos A. Guerrero, Benjamin D. Hafensteiner, David W. Lin, Jeremy M. Richter
Publikováno v:
ARKIVOC, Vol 2006, Iss 7, Pp 310-325 (2006)
Externí odkaz:
https://doaj.org/article/9e2831838cbd463dbe03794ff3458b47
Autor:
Maximilian D. Palkowitz, Gabriele Laudadio, Simon Kolb, Jin Choi, Martins S. Oderinde, Tamara El-Hayek Ewing, Philippe N. Bolduc, TeYu Chen, Hao Zhang, Peter T. W. Cheng, Benxiang Zhang, Michael D. Mandler, Vanna D. Blasczak, Jeremy M. Richter, Michael R. Collins, Ryan L. Schioldager, Martin Bravo, T. G. Murali Dhar, Benjamin Vokits, Yeheng Zhu, Pierre-Georges Echeverria, Michael A. Poss, Scott A. Shaw, Sebastian Clementson, Nadia Nasser Petersen, Pavel K. Mykhailiuk, Phil S. Baran
Publikováno v:
Journal of the American Chemical Society. 144:17709-17720
A useful protocol for achieving decarboxylative cross-coupling (DCC) of redox-active esters (RAE, isolated or generated in situ) and halo(hetero)arenes is reported. This pragmatically focused study employs a unique Ag-Ni electrocatalytic platform to
Autor:
E. Scott Priestley, Jacques Banville, Daniel Deon, Laurence Dubé, Marc Gagnon, Julia Guy, Philippe Lapointe, Jean-François Lavallée, Alain Martel, Serge Plamondon, Roger Rémillard, Edward Ruediger, François Tremblay, Shana L. Posy, Victor R. Guarino, Jeremy M. Richter, Jianqing Li, Anuradha Gupta, Muthalagu Vetrichelvan, T. J. Balapragalathan, Arvind Mathur, Ji Hua, Mario Callejo, Jocelyne Guay, Chi Shing Sum, Mary Ellen Cvijic, Carol Watson, Pancras Wong, Jing Yang, Michel Bouvier, David A. Gordon, Ruth R. Wexler, Anne Marinier
Publikováno v:
Journal of Medicinal Chemistry. 65:8843-8854
Protease-activated receptor 4 (PAR4) is a G-protein coupled receptor that is expressed on human platelets and activated by the coagulation enzyme thrombin. PAR4 plays a key role in blood coagulation, and its importance in pathological thrombosis has
Autor:
Jeremy M. Richter, J. Alex Bates, Peter Gargalovic, Joelle M. Onorato, Claudia Generaux, Tao Wang, David A. Gordon, Ruth R. Wexler, Heather J. Finlay
Publikováno v:
Bioorganicmedicinal chemistry letters. 73
Agonism of the apelin receptor (APJ) has demonstrated beneficial effects in models of heart failure. We have previously disclosed compounds such as 4, which showed good APJ agonist activity but were metabolized to the mono-demethylated, non-interconv
Autor:
Minyan Li, Jennifer X. Qiao, Jason S. Chen, Jin-Quan Yu, Jeremy M. Richter, Martin D. Eastgate, Shaoqun Qian, William R. Ewing, Zi-Qi Li, Steven R. Wisniewski
Publikováno v:
Organic Letters. 22:3960-3963
Pd(II)-catalyzed C-H lactonization of o-methyl benzoic acid substrates has been achieved using molecular oxygen as the oxidant. This finding provides a rare example of C-H oxygenation through Pd(II)/Pd(0) catalysis as well as a method to construct bi
Publikováno v:
Journal of the American Chemical Society. 142:5117-5125
Saturated azacycles are commonly encountered in bioactive compounds and approved therapeutic agents. The development of methods for functionalization of the α-methylene C-H bonds of these highly privileged building blocks is of great importance, esp
Autor:
Shaoqun, Qian, Zi-Qi, Li, Minyan, Li, Steven R, Wisniewski, Jennifer X, Qiao, Jeremy M, Richter, William R, Ewing, Martin D, Eastgate, Jason S, Chen, Jin-Quan, Yu
Publikováno v:
Org Lett
Pd(II)-catalyzed C–H lactonization of o-methyl benzoic acid substrates has been achieved using molecular oxygen as the oxidant. This finding provides a rare example of C–H oxygenation through Pd(II)/Pd(0) catalysis, as well as a method to constru
Autor:
Dietmar A. Seiffert, Bates J Alex, Pancras C. Wong, Rangaraj Narayanan, Joseph M. Luettgen, E. Scott Priestley, Alan R. Rendina, Jeremy M. Richter, Daniel L. Cheney, Timothy M. Harper, Anzhi Wei, Ruth R. Wexler
Publikováno v:
ACS medicinal chemistry letters. 8(1)
Two novel series of meta-linked phenylglycine-based macrocyclic FVIIa inhibitors have been designed to improve the rodent metabolic stability and PK observed with the precursor para-linked phenylglycine macrocycles. Through iterative structure-based
Publikováno v:
Angewandte Chemie International Edition. 44:609-612