Zobrazeno 1 - 10
of 283
pro vyhledávání: '"Jeremy M. Henley"'
Autor:
Hope I. Needs, Emily Glover, Gonçalo C. Pereira, Alina Witt, Wolfgang Hübner, Mark P. Dodding, Jeremy M. Henley, Ian Collinson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Mitochondria are the powerhouses of eukaryotic cells, composed mostly of nuclear-encoded proteins imported from the cytosol. Thus, problems with the import machinery will disrupt their regenerative capacity and the cell’s energy supplies
Externí odkaz:
https://doaj.org/article/76241f22b7d343e9b3d616b1e3d7924b
Autor:
Busra P. Yucel, Enaam M. Al Momany, Ashley J. Evans, Richard Seager, Kevin A. Wilkinson, Jeremy M. Henley
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Kainate receptors (KARs) are key regulators of neuronal excitability and synaptic transmission. KAR surface expression is tightly controlled in part by post-translational modifications (PTMs) of the GluK2 subunit. We have shown previously that agonis
Externí odkaz:
https://doaj.org/article/36f0f0b461134e88a10a608d423b856d
Autor:
Jithin D. Nair, Kevin A. Wilkinson, Busra P. Yucel, Christophe Mulle, Bryce Vissel, Jack Mellor, Jeremy M. Henley
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107708- (2023)
Summary: Q/R editing of the kainate receptor (KAR) subunit GluK2 radically alters recombinant KAR properties, but the effects on endogenous KARs in vivo remain largely unexplored. Here, we compared GluK2 editing-deficient mice that express ∼95% une
Externí odkaz:
https://doaj.org/article/2e9a29431f0b4c69a47eaa9ed3c10a74
Autor:
Ericks S. Soares, Ana C. Guerra de Souza, Camila A. Zanella, Ruth E. Carmichael, Jeremy M. Henley, Kevin A. Wilkinson, Helena I. Cimarosti
Publikováno v:
IBRO Neuroscience Reports, Vol 12, Iss , Pp 142-148 (2022)
Defining the molecular changes that underlie Alzheimer’s disease (AD) is an important question in neuroscience. Here, we examined changes in protein SUMOylation, and proteins involved in mitochondrial dynamics, in an in vitro model of AD induced by
Externí odkaz:
https://doaj.org/article/19fe505ab0a34d44b3e8a17f679874ac
Autor:
Luis Solabre Valois, Vanilla (Hua) Shi, Paul Bishop, Bangfu Zhu, Yasuko Nakamura, Kevin A. Wilkinson, Jeremy M. Henley
Publikováno v:
IBRO Neuroscience Reports, Vol 10, Iss , Pp 196-207 (2021)
Botulinum neurotoxins (BoNTs) are extremely potent naturally occurring poisons that act by silencing neurotransmission. Intriguingly, in addition to preventing presynaptic vesicle fusion, BoNT serotype A (BoNT/A) can also promote axonal regeneration
Externí odkaz:
https://doaj.org/article/88b4e1fe21294079ad01e8ad984e48da
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100992- (2021)
Summary: Here, we detail a surface biotinylation technique used to label surface-expressed proteins in primary neuronal cultures. Surface proteins are labeled with membrane-impermeant Sulfo-NHS-SS-biotin, and isolated by pull-down with streptavidin b
Externí odkaz:
https://doaj.org/article/c4b4ee73db4e438090f8281c73d9409d
Autor:
Chun Guo, Keri L. Hildick, Juwei Jiang, Alice Zhao, Wenbin Guo, Jeremy M. Henley, Kevin A. Wilkinson
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Dysregulation of the mitochondrial fission machinery has been linked to cell death following ischemia. Fission is largely dependent on recruitment of Dynamin-related protein 1 (Drp1) to the receptor Mitochondrial fission factor (Mff) located on the m
Externí odkaz:
https://doaj.org/article/967a5a881ee04df5b7199baccab623ed
Autor:
Jithin D. Nair, Ellen Braksator, Busra P. Yucel, Alexandra Fletcher-Jones, Richard Seager, Jack R. Mellor, Zafar I. Bashir, Kevin A. Wilkinson, Jeremy M. Henley
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103029- (2021)
Summary: It is well established that long-term depression (LTD) can be initiated by either NMDA or mGluR activation. Here we report that sustained activation of GluK2 subunit-containing kainate receptors (KARs) leads to α-amino-3-hydroxy-5-methyl-4-
Externí odkaz:
https://doaj.org/article/1781056074164a7f8f0625a42bd074cf
Autor:
Alexandra Fletcher-Jones, Keri L. Hildick, Ashley J. Evans, Yasuko Nakamura, Jeremy M. Henley, Kevin A. Wilkinson
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Externí odkaz:
https://doaj.org/article/3f88414862e745d28f818b98f641fa70
Autor:
Alexandra Fletcher-Jones, Keri L. Hildick, Ashley J. Evans, Yasuko Nakamura, Jeremy M. Henley, Kevin A. Wilkinson
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The endocannabinoid system (ECS) acts as a negative feedback mechanism to suppress synaptic transmission and plays a major role in a diverse range of brain functions including, for example, the regulation of mood, energy balance, and learning and mem
Externí odkaz:
https://doaj.org/article/f249bbc558c142758cf642127efce12c