Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Jeremy M Sivak"'
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract Lipoxins are small lipids that are potent endogenous mediators of systemic inflammation resolution in a variety of diseases. We previously reported that Lipoxins A4 and B4 (LXA4 and LXB4) have protective activities against neurodegenerative
Externí odkaz:
https://doaj.org/article/6dbf4018fefc4d41be13e85194369231
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83049 (2013)
Astrocytes are the most abundant glial cell in the retinal nerve fiber layer (NFL) and optic nerve head (ONH), and perform essential roles in maintaining retinal ganglion cell (RGC) detoxification and homeostasis. Mature astrocytes are relatively qui
Externí odkaz:
https://doaj.org/article/065243d7f64a4ca1a4522751b671e2e2
Autor:
Arthur Aubry, Joel D. Pearson, Jason Charish, Tao Yu, Jeremy M. Sivak, Dimitris P. Xirodimas, Hervé Avet-Loiseau, Jill Corre, Philippe P. Monnier, Rod Bremner
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113711- (2024)
Externí odkaz:
https://doaj.org/article/e123ac04ad4e41e196e403a93c6013ec
Autor:
Arthur Aubry, Joel D. Pearson, Jason Charish, Tao Yu, Jeremy M. Sivak, Dimitris P. Xirodimas, Hervé Avet-Loiseau, Jill Corre, Philippe P. Monnier, Rod Bremner
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112925- (2023)
Summary: The neddylation inhibitor MLN4924/Pevonedistat is in clinical trials for multiple cancers. Efficacy is generally attributed to cullin RING ligase (CRL) inhibition, but the contribution of non-CRL targets is unknown. Here, CRISPR screens map
Externí odkaz:
https://doaj.org/article/98133b06f2024ab69e0484aa57d6b411
Publikováno v:
Journal of Cellular Physiology. 237
Publikováno v:
J Cell Physiol
Glaucoma is a common neurodegenerative blinding disease that is closely associated with chronic biomechanical strain at the optic nerve head (ONH). Yet, the cellular injury and mechanosensing mechanisms underlying the resulting damage have remained c
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Glaucoma is a chronic and progressive neurodegenerative disease of the optic nerve resulting in loss of retinal ganglion cells (RGCs) and vision. The most prominent glaucoma risk factor is increased intraocular pressure (IOP), and most models focus o
Publikováno v:
Experimental Eye Research. 183:88-97
Glaucoma describes a distinct optic neuropathy with complex etiology and a variety of associated risk factors, but with similar pathological endpoints. Risk factors such as age, increased intraocular pressure (IOP), low mean arterial pressure, and au
Autor:
Alejandro Fernandez-Escobar, Jeremy M Sivak, C. Justin Lee, Amy J. Ramsey, Junhui Wang, Beverley A. Orser, Nathan K. Chan, Junsung Woo, Dian Shi Wang, Darren Chan, Sinziana Avramescu, Robert P. Bonin, Fariya Mostafa, Irene Lecker, Yu-Feng Xie, Gang Lei, Kirusanthy Kaneshwaran
Publikováno v:
Anesthesiology. 129:477-489
What We Already Know about This Topic What This Article Tells Us That Is New Background Postoperative delirium is associated with poor long-term outcomes and increased mortality. General anesthetic drugs may contribute to delirium because they increa
Autor:
Gerold Schmitt-Ulms, Samih Alqawlaq, Joseph D'Ercole, Anita H. Corbett, Declan Williams, Jeffrey L. Wrana, Alessandro Datti, Darren Chan, Sara W. Leung, Jeremy M Sivak, Alessandra Tuccitto, Izhar Livne-Bar
Publikováno v:
The Journal of Biological Chemistry
Astrocytes can support neuronal survival through a range of secreted signals that protect against neurotoxicity, oxidative stress, and apoptotic cascades. Thus, analyzing the effects of the astrocyte secretome may provide valuable insight into these