Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Jeremy M Simon"'
Autor:
Julie C Necarsulmer, Jeremy M Simon, Baggio A Evangelista, Youjun Chen, Xu Tian, Sara Nafees, Ariana B Marquez, Huijun Jiang, Ping Wang, Deepa Ajit, Viktoriya D Nikolova, Kathryn M Harper, J Ashley Ezzell, Feng-Chang Lin, Adriana S Beltran, Sheryl S Moy, Todd J Cohen
Publikováno v:
eLife, Vol 12 (2023)
TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by aggregation and mislocalization of the nucleic acid-binding protein TDP-43 and subseque
Externí odkaz:
https://doaj.org/article/1ef60b65b631406abd7b36cb7384d395
Autor:
Hyojin Kim, Eric B Gao, Adam Draper, Noah C Berens, Hanna Vihma, Xinyuan Zhang, Alexandra Higashi-Howard, Kimberly D Ritola, Jeremy M Simon, Andrew J Kennedy, Benjamin D Philpot
Publikováno v:
eLife, Vol 11 (2022)
Pitt-Hopkins syndrome (PTHS) is a neurodevelopmental disorder caused by monoallelic mutation or deletion in the transcription factor 4 (TCF4) gene. Individuals with PTHS typically present in the first year of life with developmental delay and exhibit
Externí odkaz:
https://doaj.org/article/3dc966f5e657438580d1f757ebc53175
Autor:
Wentong Fang, Chengheng Liao, Rachel Shi, Jeremy M Simon, Travis S Ptacek, Giada Zurlo, Youqiong Ye, Leng Han, Cheng Fan, Lei Bao, Christopher Llynard Ortiz, Hong-Rui Lin, Ujjawal Manocha, Weibo Luo, Yan Peng, William Y Kim, Lee-Wei Yang, Qing Zhang
Publikováno v:
eLife, Vol 10 (2021)
Triple-negative breast cancer (TNBC) is an aggressive and highly lethal disease, which warrants the critical need to identify new therapeutic targets. We show that Zinc Fingers and Homeoboxes 2 (ZHX2) is amplified or overexpressed in TNBC cell lines
Externí odkaz:
https://doaj.org/article/e24d4ed6d68f4043945935d9d6a7af3c
Autor:
Gregory R Keele, Bryan C Quach, Jennifer W Israel, Grace A Chappell, Lauren Lewis, Alexias Safi, Jeremy M Simon, Paul Cotney, Gregory E Crawford, William Valdar, Ivan Rusyn, Terrence S Furey
Publikováno v:
PLoS Genetics, Vol 16, Iss 1, p e1008537 (2020)
Gene transcription profiles across tissues are largely defined by the activity of regulatory elements, most of which correspond to regions of accessible chromatin. Regulatory element activity is in turn modulated by genetic variation, resulting in va
Externí odkaz:
https://doaj.org/article/d11b2185ebde45e2b7141adfb9f116db
Autor:
Angela M Mabb, Jeremy M Simon, Ian F King, Hyeong-Min Lee, Lin-Kun An, Benjamin D Philpot, Mark J Zylka
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156439 (2016)
Topoisomerase 1 (TOP1) inhibitors, including camptothecin and topotecan, covalently trap TOP1 on DNA, creating cleavage complexes (cc's) that must be resolved before gene transcription and DNA replication can proceed. We previously found that topotec
Externí odkaz:
https://doaj.org/article/6431e9850d2f491cb7744d9646b92266
Publikováno v:
Alcohol. 106:1-9
Alcohol exposure during the formation and closure of the neural tube, or neurulation (embryonic day [E] 8-10 in mice; ∼4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e48bdabf243f087aabd091967a869c
https://doi.org/10.1016/j.alcohol.2022.09.001
https://doi.org/10.1016/j.alcohol.2022.09.001
Autor:
William Y. Kim, Ian J. Davis, Jeremy M. Simon, Austin J. Hepperla, Kathryn H. Gessner, Janet Y. Leung, Mi Zhou
Supplementary Data from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acd9ac6ece0b1dcbf7b586a7187e348
https://doi.org/10.1158/2326-6066.22544229
https://doi.org/10.1158/2326-6066.22544229
Autor:
William Y. Kim, Ian J. Davis, Jeremy M. Simon, Austin J. Hepperla, Kathryn H. Gessner, Janet Y. Leung, Mi Zhou
Clear cell renal cell carcinoma (ccRCC) is considered an immunotherapy-responsive disease; however, the reasons for this remain unclear. Studies have variably implicated PBRM1 mutations as a predictive biomarker of immune checkpoint blockade (ICB) re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00964cde4fd0f94aabbdc277c4898b46
https://doi.org/10.1158/2326-6066.c.6550584.v1
https://doi.org/10.1158/2326-6066.c.6550584.v1
Autor:
William Y. Kim, Ian J. Davis, Jeremy M. Simon, Austin J. Hepperla, Kathryn H. Gessner, Janet Y. Leung, Mi Zhou
Supplementary Figure from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400cb2c8c6033f1649c0301e24d3ac3b
https://doi.org/10.1158/2326-6066.22544226
https://doi.org/10.1158/2326-6066.22544226
Autor:
Ian J. Davis, Kathleen Kaiser-Rogers, Scott V. Smith, Jeremy M. Simon, Travis Sapp, Andres Rojas, Sam Wu, Billie M. Moats-Staats, Andrew W. McFadden, Nicholas C. Gomez, Mukund Patel
Sup. Figure 1. MHH-ES-1 and RD-ES are triploid for chromosome 10. Sup. Figure 2. PTEN copy number variation in primary Ewing sarcoma. Sup. Figure 3. PTEN immunofluoresence is concordant with immunoblotting. Sup Figure 4. Immunofluoresence and immunoh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d59997c08d132b4db71670f217239c9
https://doi.org/10.1158/1541-7786.22511833.v1
https://doi.org/10.1158/1541-7786.22511833.v1