Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Jeremy Luke"'
Publikováno v:
Human Gene Therapy. 28:125-134
We previously developed a mini-intronic plasmid (MIP) expression system in which the essential bacterial elements for plasmid replication and selection are placed within an engineered intron contained within a universal 5′ UTR noncoding exon. Like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b217e204596c4534e09210d3f3ce7f70
https://doi.org/10.1089/hum.2016.140
https://doi.org/10.1089/hum.2016.140
Autor:
James A. Williams, Douglas N. Foster, Jeremy Luke, Cheryl A. Lancto, Clague P. Hodgson, Michelle Kromm, Linda K. Foster, Aaron E. Carnes, Brian McComb
Publikováno v:
Avian Diseases. 58:566-571
Clostridium septicum and its associated cytolytic α toxin, along with several other clostridial species, has been implicated as the causative agent of gangrenous dermatitis. A recombinant noncytolytic C. septicum α toxin (NCAT) peptide was develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c716c2d5d0cf67d7625e87ffe8d69182
https://doi.org/10.1637/10826-032314-reg.1
https://doi.org/10.1637/10826-032314-reg.1
Autor:
Jeremy Luke
Publikováno v:
BMJ (Clinical research ed.). 353
I was saddened that The BMJ offered no balance to the views proposed by Barrett.1 The article should have been called “The commissioning of NHS services is doing an appalling job of helping people with gender dysphoria.” General practice is going
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644bbf615d864e111a6d1d40a9160a73
https://pubmed.ncbi.nlm.nih.gov/27118655
https://pubmed.ncbi.nlm.nih.gov/27118655
Autor:
Jonas Söderholm, James A. Williams, Clague P. Hodgson, J. Thomas August, Michael Gale, Jeremy Luke, Gregory G. Simon, John S. Errett
Publikováno v:
Journal of Virology. 85:1370-1383
Increasing levels of plasmid vector-mediated activation of innate immune signaling pathways is an approach to improve DNA vaccine-induced adaptive immunity for infectious disease and cancer applications. Retinoic acid-inducible gene I (RIG-I) is a cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba609ef3b16e00849e9ad2e5d21d408
https://doi.org/10.1128/jvi.01250-10
https://doi.org/10.1128/jvi.01250-10
Autor:
Sheryl Anderson, Clague P. Hodgson, James A. Williams, Angela Schukar, Jeremy Luke, Aaron E. Carnes, Justin M. Vincent
Publikováno v:
Biotechnology and Bioengineering. 108:354-363
Industrial plasmid DNA manufacturing processes are needed to meet the quality, economy, and scale requirements projected for future commercial products. We report development of a modified plasmid fermentation copy number induction profile that incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822afb3f86140102fdd797083f636096
https://doi.org/10.1002/bit.22936
https://doi.org/10.1002/bit.22936
Autor:
Sheryl Anderson, Aaron E. Carnes, James A. Williams, Angela Schukar, Justin M. Vincent, Jeremy Luke, Clague P. Hodgson
Publikováno v:
The Journal of Gene Medicine. 12:818-831
Background For safety considerations, regulatory agencies recommend the elimination of antibiotic resistance markers and non-essential sequences from plasmid DNA-based gene medicines. In the present study, we analyzed antibiotic-free (AF) vector desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520dc08ccf261fe8600f0321627f19fb
https://doi.org/10.1002/jgm.1499
https://doi.org/10.1002/jgm.1499
Publikováno v:
Molecular Biotechnology. 47:43-49
Some DNA vaccine and gene therapy vector-encoded transgenes are toxic to the E. coli plasmid production host resulting in poor production yields. For plasmid products undergoing clinical evaluation, sequence modification to eliminate toxicity is unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8911e54de434cfe4e9187b74a2e03d43
https://doi.org/10.1007/s12033-010-9310-5
https://doi.org/10.1007/s12033-010-9310-5
Publikováno v:
Vaccine. 27:6454-6459
To ensure safety, regulatory agencies recommend elimination of antibiotic resistance markers from therapeutic and vaccine plasmid DNA vectors. Here, we describe the development and application of a novel antibiotic-free selection system. Vectors inco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454ccdb0ba6b2771420aae394a9a54aa
https://doi.org/10.1016/j.vaccine.2009.06.017
https://doi.org/10.1016/j.vaccine.2009.06.017
Autor:
Aaron E. Carnes, Sarah Langtry, Clague P. Hodgson, James A. Williams, Jeremy Luke, Sheryl Anderson
Publikováno v:
Biotechnology and Bioengineering. 103:1129-1143
DNA vaccines have tremendous potential for rapid deployment in pandemic applications, wherein a new antigen is ‘plugged’ into a validated vector, and rapidly produced in a validated, fermentation - purification process. For this application, it i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade4f1922630459592137d56e65c6cd6
https://doi.org/10.1002/bit.22347
https://doi.org/10.1002/bit.22347
Publikováno v:
VACCINE
DNA vaccination is effective in inducing potent immunity in mice; however it appears to be less so in large animals. Increasing the dose of DNA plasmid to activate innate immunity has been shown to improve DNA vaccine adaptive immunity. Retinoic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a982009df98850deab9f32a97266e7b9
https://pubmed.ncbi.nlm.nih.gov/26079613
https://pubmed.ncbi.nlm.nih.gov/26079613