Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jeremy Lotto"'
Autor:
Avinash Thakur, Kwangjin Park, Rebecca Cullum, Bettina M. Fuglerud, Mina Khoshnoodi, Sibyl Drissler, Tabea L. Stephan, Jeremy Lotto, Donghwan Kim, Frank J. Gonzalez, Pamela A. Hoodless
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Hepatocyte nuclear factor 4A (HNF4A/NR2a1), a transcriptional regulator of hepatocyte identity, controls genes that are crucial for liver functions, primarily through binding to enhancers. In mammalian cells, active and primed enhancers are
Externí odkaz:
https://doaj.org/article/509818b666a44a0e9f65dd70f8d00e81
Autor:
Jeremy Lotto, Rebecca Cullum, Sibyl Drissler, Martin Arostegui, Victoria C. Garside, Bettina M. Fuglerud, Makenna Clement-Ranney, Avinash Thakur, T. Michael Underhill, Pamela A. Hoodless
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Epithelial-to-mesenchymal transitions (EMTs) of both endocardium and epicardium guide atrioventricular heart valve formation, but the cellular complexity and small scale of this tissue have restricted analyses. To circumvent these issues, we
Externí odkaz:
https://doaj.org/article/a8e5d6366264478ba5947de946bd31c2
Publikováno v:
Nature Reviews Gastroenterology & Hepatology.
Autor:
Bettina M Fuglerud, Sibyl Drissler, Jeremy Lotto, Tabea L Stephan, Avinash Thakur, Rebecca Cullum, Pamela A Hoodless
Publikováno v:
Nucleic acids research. 50(15)
The transcription factor SOX9 is activated at the onset of endothelial-to-mesenchymal transition (EndMT) during embryonic development and in pathological conditions. Its roles in regulating these processes, however, are not clear. Using human umbilic
Autor:
Jeremy Lotto, Rebecca Cullum, Sibyl Drissler, Martin Arostegui, Victoria Garside, Bettina Fuglerud, Avinash Thakur, Tully Underhill, Pamela Hoodless
The epithelial-to-mesenchymal transition (EMT) is a process critical for wound healing, fibrosis, and cancer metastasis, but is also essential for atrioventricular valve formation, where distinct EMTs of endocardium (EndMT) and epicardium (EpiMT) gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e21f63775427b978bd7aa6d67c2a132b
https://doi.org/10.21203/rs.3.rs-1647065/v1
https://doi.org/10.21203/rs.3.rs-1647065/v1
Autor:
Steven J. Cooke, Jeremy Lotto, Scott G. Hinch, David A. Patterson, Erika J. Eliason, Melissa Dick, Kendra A. Robinson
Publikováno v:
Canadian Journal of Fisheries and Aquatic Sciences. 77:1749-1757
Numerous laboratory and field studies have found that female Pacific salmon have higher mortality than males during their once-in-a-lifetime upriver spawning migration. However, the proximate cause(s) of this increased mortality are poorly understood
Autor:
Tabea L. Stephan, Sibyl Drissler, Pamela A. Hoodless, Stephanie A. Campbell, Jeremy Lotto, Rebecca Cullum
Publikováno v:
Development. 148
Liver development is controlled by key signals and transcription factors that drive cell proliferation, migration, differentiation and functional maturation. In the adult liver, cell maturity can be perturbed by genetic and environmental factors that
Autor:
Sibyl Drissler, Pamela A. Hoodless, Erin M. Bell, Dana Pe'er, Vidur Garg, Sonja Nowotschin, Rebecca Cullum, Wei Wei, Ying-Yi Kuo, Deanna M. Church, Anna-Katerina Hadjantonakis, Manu Setty, Jeremy Lotto, Stéphane C. Boutet
Publikováno v:
Cell
The cellular complexity and scale of the early liver have constrained analyses examining its emergence during organogenesis. To circumvent these issues, we analyzed 45,334 single-cell transcriptomes from embryonic day (E)7.5, when endoderm progenitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60556a0f955df3cb2f52bf57a334c8dd
https://europepmc.org/articles/PMC7643810/
https://europepmc.org/articles/PMC7643810/
Autor:
Tabea L. Stephan, Bettina M. Fuglerud, Sibyl Drissler, Pamela A. Hoodless, Rebecca Cullum, Avinash Thakur, Jeremy Lotto
The transcription factor SOX9 is expressed in multiple tissues during embryogenesis and directs developmental processes. SOX9 is activated upon endothelial-to-mesenchymal transition (EndMT) in the developing heart, but its role in regulating this pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ff8d7593e243307db2cd2c07d083815
https://doi.org/10.1101/2020.09.11.293993
https://doi.org/10.1101/2020.09.11.293993
Autor:
Vaishali Moudgil, Jung-Chien Cheng, Wei Wei, Frank J. Gonzalez, Jeremy Lotto, Evan Y. Wang, Bettina M. Fuglerud, Misha Bilenky, Pamela A. Hoodless, Jasper Wong, Colum P. Walsh, Donghwan Kim, Shu Huei Tsai, Mohammad M. Karimi, Nafeel Ahmed, Matthew Mingay, Martin Hirst, Tabea L. Stephan, Rebecca Cullum, Avinash Thakur
Publikováno v:
Hepatology
Cell-fate determination is influenced by interactions between master transcription factors (TFs) and cis-regulatory elements. Hepatocyte nuclear factor 4 alpha (HNF4A), a liver-enriched TF, acts as a master controller in specification of hepatic prog