Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jeremy Little"'
Autor:
Yan Weng, Christopher T. Salatto, Robert V. Stanton, Debra Moshinsky, Debra A. DiMattia, Mei Liu, John M. Kreeger, Robert Dullea, Jessie Qian, Marc D. Roy, Tracey Clark, Jeremy Little, Evan Walters, Simone Sciabola, Tracy Chen
Publikováno v:
Nucleic Acid Therapeutics. 22:344-359
A series of insertion patterns for chemically modified nucleotides [2'-O-methyl (2'-OMe), 2'-fluoro (2'-F), methoxyethyl (MOE), locked nucleic acid (LNA), and G-Clamp] within antisense gapmers is studied in vitro and in vivo in the context of the glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7c8f19b047c941c55b125e110c3fdf
https://doi.org/10.1089/nat.2012.0366
https://doi.org/10.1089/nat.2012.0366
Autor:
Matthew O. Duffey, Tricia J. Vos, Ruth Adams, Jennifer Alley, Justin Anthony, Cynthia Barrett, Indu Bharathan, Douglas Bowman, Nancy J. Bump, Ryan Chau, Courtney Cullis, Denise L. Driscoll, Amy Elder, Nancy Forsyth, Jonathan Frazer, Jianping Guo, Luyi Guo, Marc L. Hyer, David Janowick, Bheemashankar Kulkarni, Su-Jen Lai, Kerri Lasky, Gang Li, Jing Li, Debra Liao, Jeremy Little, Bo Peng, Mark G. Qian, Dominic J. Reynolds, Mansoureh Rezaei, Margaret Porter Scott, Todd B. Sells, Vaishali Shinde, Qiuju Judy Shi, Michael D. Sintchak, Francois Soucy, Kevin T. Sprott, Stephen G. Stroud, Michelle Nestor, Irache Visiers, Gabriel Weatherhead, Yingchun Ye, Natalie D’Amore
Publikováno v:
Journal of medicinal chemistry. 55(1)
This article describes the discovery of a series of potent inhibitors of Polo-like kinase 1 (PLK1). Optimization of this benzolactam-derived chemical series produced an orally bioavailable inhibitor of PLK1 (12c, MLN0905). In vivo pharmacokinetic-pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71360d15b44c1a6fcfa39401ef5e4fbf
https://pubmed.ncbi.nlm.nih.gov/22070629
https://pubmed.ncbi.nlm.nih.gov/22070629
Autor:
Sergei Timofeevski, William R. Tschantz, Maura E. Charlton, Jeremy Little, Paul Bauer, Tracy Chen, Robert V. Stanton, Natasha M. Kablaoui, Junli Feng, Ping Chen
Publikováno v:
The Biochemical journal. 420(2)
JNK1 (c-Jun N-terminal kinase 1) plays a crucial role in the regulation of obesity-induced insulin resistance and is implicated in the pathology of Type 2 diabetes. Its partner, JIP1 (JNK-interacting protein 1), serves a scaffolding function that fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058c6af091742224c6a3e73aadb5f356
https://pubmed.ncbi.nlm.nih.gov/19243309
https://pubmed.ncbi.nlm.nih.gov/19243309
Autor:
Tracy Chen, Natasha Kablaoui, Jeremy Little, Sergei Timofeevski, William R. Tschantz, Ping Chen, Junli Feng, Maura Charlton, Robert Stanton, Paul Bauer
Publikováno v:
Biochemical Journal; May2009, Vol. 420 Issue 2, p283-294, 12p