Design, Synthesis, and Antiprotozoal Evaluation of New Promising 2,9-Bis[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline Derivatives, a Potential Alternative Scaffold to Drug Efflux

Autor: Jean Guillon, Anita Cohen, Clotilde Boudot, Sarah Monic, Solène Savrimoutou, Stéphane Moreau, Sandra Albenque-Rubio, Camille Lafon-Schmaltz, Alexandra Dassonville-Klimpt, Jean-Louis Mergny, Luisa Ronga, Mikel Bernabeu de Maria, Jeremy Lamarche, Cristina Dal Lago, Eric Largy, Valérie Gabelica, Serge Moukha, Pascale Dozolme, Patrice Agnamey, Nadine Azas, Catherine Mullié, Bertrand Courtioux, Pascal Sonnet

Publikováno v: Pathogens, Vol 11, Iss 11, p 1339 (2022)

A series of novel 2,9-bis[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline derivatives was designed, synthesized, and evaluated in vitro against three protozoan parasites (Plasmodium falciparum, Leishmania donovani and Trypanosoma brucei bru

Externí odkaz: https://doaj.org/article/b961a7f728654f89bcdb5422415e1f2c

Comparative reactivity of medicinal gold(i) compounds with the cyclic peptide vasopressin and its diselenide analogue

Autor: Lara Massai, Emmanuelle Cordeau, Luisa Ronga, Ryszard Lobinski, Jeremy Lamarche, Luigi Messori, Christine Enjalbal, Enrique Alcoceba Álvarez

Publikováno v: Dalton Transactions
Dalton Transactions, Royal Society of Chemistry, 2021, 50 (47), pp.17487-17490. ⟨10.1039/d1dt03470g⟩

International audience; The reactions of the medicinal gold(i) compound auranofin and its close analogues with vasopressin and the diselenide analogue were comparatively investigated by LC-electrospray MS/MS. Evidence is gained of the possible cleava

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d10cfd980e17b66cbd84f5eb0fb207
https://doi.org/10.1039/d1dt03470g

Design, synthesis, and antiproliferative effect of 2,9-bis[4-(pyridinylalkylaminomethyl)phenyl]-1,10-phenanthroline derivatives on human leukemic cells by targeting G-quadruplex

Autor: Sandra Rubio, Jean Guillon, Solène Savrimoutou, Marie-Claude Viaud-Massuard, Jean-Louis Mergny, Luisa Ronga, Eric Largy, Matthieu Ranz, Marie Brachet-Botineau, Frédéric Rosu, Jacky Ferrer, Jeremy Lamarche, Fabrice Gouilleux, Valérie Gabelica, Vittoria Milano, Aurore Guédin-Beaurepaire, Edith Chevret, Vanessa Desplat, Caroline Denevault-Sabourin, Stéphane Moreau

Publikováno v: Archiv der Pharmazie / Chemistry in Life Sciences
Archiv der Pharmazie / Chemistry in Life Sciences, Wiley-VCH Verlag, In press, ⟨10.1002/ardp.202000450⟩
Archiv der Pharmazie / Chemistry in Life Sciences, 2021, 354, pp.e2000450. ⟨10.1002/ardp.202000450⟩

International audience; Current multiagent chemotherapy regimens have improved the cure rate in acute leukemia patients, but they are highly toxic and poorly efficient in relapsed patients. To improve the treatment approaches, new specific molecules

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ccebe3fb18cf78eb441ad102fa32a0d
https://pubmed.ncbi.nlm.nih.gov/33852185

Resveratrol-Induced Xenophagy Promotes Intracellular Bacteria Clearance in Intestinal Epithelial Cells and Macrophages

Autor: Jana Al Azzaz, Aurélie Rieu, Virginie Aires, Dominique Delmas, Johanna Chluba, Pascale Winckler, Marie-Agnès Bringer, Jérémy Lamarche, Dominique Vervandier-Fasseur, Frédéric Dalle, Pierre Lapaquette, Jean Guzzo

Publikováno v: Frontiers in Immunology, Vol 9 (2019)

Autophagy is a lysosomal degradation process that contributes to host immunity by eliminating invasive pathogens and the modulating inflammatory response. Several infectious and immune disorders are associated with autophagy defects, suggesting that

Externí odkaz: https://doaj.org/article/cbe8d98d3ebf425abeddae0f38622201