Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jeremy K. Haakenson"'
Autor:
Jeannine A. Ott, Jeremy K. Haakenson, Abigail R. Kelly, Claire Christian, Michael F. Criscitiello, Vaughn V. Smider
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In the mammalian immune system, the surrogate light chain (SLC) shapes the antibody repertoire during B cell development by serving as a checkpoint for production of functional heavy chains (HC). Structural studies indicate that tail regions of VpreB
Externí odkaz:
https://doaj.org/article/be2d465e729c447ebc5209b913d1b86a
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Typical antibodies found in humans and mice usually have short CDR H3s and generally flat binding surfaces. However, cows possess a subset of antibodies with ultralong CDR H3s that can range up to 70 amino acids and form a unique “stalk and knob”
Externí odkaz:
https://doaj.org/article/21963ece231745aca15cc2ea3f16ece3
Autor:
Jeannine A. Ott, Christian Mitchell, Morgan Sheppard, Thad C. Deiss, J. M. Cody Horton, Jeremy K. Haakenson, Ruiqi Huang, Abigail R. Kelley, Brian W. Davis, James N. Derr, Vaughn V. Smider, Michael F. Criscitiello
Publikováno v:
Immunogenetics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::087bba0250895a5fbf1af3d1f0b2c893
https://doi.org/10.1007/s00251-023-01305-9
https://doi.org/10.1007/s00251-023-01305-9
Autor:
Jeremy K. Haakenson, Gabrielle Warner, Thaddeus C. Deiss, Michael F. Criscitiello, Waithaka Mwangi, Vaughn V. Smider
Publikováno v:
ImmunoHorizons
Ab diversity in most vertebrates results from the assortment of amino acid side chains on CDR loops formed through V(D)J recombination. Cows (Bos taurus) have a low combinatorial diversity potential because of a small number of highly homologous V, D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fc7f80a6958c790434d02422ec2652
https://doi.org/10.4049/immunohorizons.1900058
https://doi.org/10.4049/immunohorizons.1900058
Autor:
Christian D. Mitchell, Ashley J Marchand, Kelly Head, Jeremy K Haakenson, Abigail Kelley, Thaddeus C Deiss, James N Derr, Vaughn V Smider, Michael F Criscitiello
Publikováno v:
The Journal of Immunology. 206:19.08-19.08
Cattle has a restricted repository of immunoglobulin heavy chain gene segments with only one family of V, 4 J and 16 D segments functional. Among these segments are a V and D that, together, encode a heavy chain with an ultralong CDR3 region which ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b20977860179ad7b1e81924c96f048d
https://doi.org/10.4049/jimmunol.206.supp.19.08
https://doi.org/10.4049/jimmunol.206.supp.19.08
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Typical antibodies found in humans and mice usually have short CDR H3s and generally flat binding surfaces. However, cows possess a subset of antibodies with ultralong CDR H3s that can range up to 70 amino acids and form a unique "stalk and knob" str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c510b62de774325a00f6769e31eb4cf4
https://www.frontiersin.org/article/10.3389/fimmu.2018.01262/full
https://www.frontiersin.org/article/10.3389/fimmu.2018.01262/full
Autor:
Jeremy K. Haakenson, Vaughn V. Smider, Ian A. Wilson, Michael F. Criscitiello, Thaddeus C. Deiss, Robyn L. Stanfield
Antibodies are the key circulating molecules that have evolved to fight infection by the adaptive immune system of vertebrates. Typical antibodies of most species contain six complementarity determining regions (CDRs), where the third CDR of the heav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388accb4540d069dcb161bd36f625ffd
https://doi.org/10.1016/bs.ai.2017.12.004
https://doi.org/10.1016/bs.ai.2017.12.004
Autor:
James H. Adair, Jill P. Smith, Jeremy K. Haakenson, Christopher O. McGovern, Todd E. Fox, Sarah A Knupp, Evan L. Gilius, Mark Kester, Erhan I. Altinoglu, Timothy M. Ritty, Jeremy A. Hengst, Brian M. Barth, Sriram S. Shanmugavelandy, James M. Kaiser
Publikováno v:
ACS Nano. 7:2132-2144
Tumor-associated inflammation mediates the development of a systemic immunosuppressive milieu that is a major obstacle to effective treatment of cancer. Inflammation has been shown to promote the systemic expansion of immature myeloid cells which hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60fb69f3eed18a8df562677fd5426843
https://doi.org/10.1021/nn304862b
https://doi.org/10.1021/nn304862b
Autor:
Andrea Manni, Changliang Fu, Timothy K. Cooper, Andrei Khokhlatchev, Mark Kester, Samuel S. Linton, Junjia Zhu, Younhee J. Choi, Peter Zaki, Cheng Dong, Pu Zhang, Jeremy K. Haakenson, Todd E. Fox
Publikováno v:
The Journal of biological chemistry. 290(13)
The ceramide nanoliposome (CNL) has shown promise in being able to treat a variety of primary tumors. However, its potential for treating metastatic cancer remains unknown. In this study, we demonstrate that CNL increases anoikis while preventing can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c1d0b0d960c8db50aeae056652f3f6
https://pubmed.ncbi.nlm.nih.gov/25681441
https://pubmed.ncbi.nlm.nih.gov/25681441
Publikováno v:
Bioactive Sphingolipids in Cancer Biology and Therapy ISBN: 9783319207490
It is well established that sphingolipids are crucial signal transducers regulating several cellular processes like growth, proliferation, response to stress, differentiation, senescence, autophagy and apoptosis. The critical role of sphingolipids in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bf7b41a6aadb9925841892703fdf977
https://doi.org/10.1007/978-3-319-20750-6_18
https://doi.org/10.1007/978-3-319-20750-6_18