Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jeremy John Payne"'
Autor:
Xichen Lin, Michael E. Muratore, Huijie Li, Ami S. Lakdawala, Jakob Busch-Petersen, Ruth R. Osborn, David D. Miller, Jeffrey K. Kerns, Rick P. C. Cousins, Ian Robert Baldwin, Paul Bamborough, John Yonchuk, Ann M. Bullion, Lin Guoliang, Jeffrey C. Boehm, Wei Fu, John A. Christopher, Edward F. Webb, Roderick S. Davis, William L. Rumsey, Rita Field, Jeremy John Payne, Hong Nie
Publikováno v:
ACS Medicinal Chemistry Letters. 9:1164-1169
[Image: see text] IκB kinase β (IKKβ or IKK2) is a key regulator of nuclear factor kappa B (NF-κB) and has received attention as a therapeutic target. Herein we report on the optimization of a series of 3,5-disubstituted-indole-7-carboxamides for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782cb7b7a63c400db0be5e5461917822
https://doi.org/10.1021/acsmedchemlett.8b00291
https://doi.org/10.1021/acsmedchemlett.8b00291
Autor:
Heather Hobbs, Rick P. C. Cousins, Caroline Whitworth, Ruth R. Osborn, Cesar Ramirez-Molina, Giorgia Vicentini, Chris Ioannou, Chun-wa Chung, Jeremy John Payne, Michelle L. Heathcote, Michael David Barker, Sebastien Andre Campos, Paul Faulder, Mary A. Morse, William L. Rumsey, John Liddle, Daniel Terence Tape, John Martin Pritchard, Rick Williamson, Duncan S. Holmes, Paul Bamborough
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5222-5226
The lead optimization of a series of potent azaindole IKK2 inhibitors is described. Optimization of the human whole blood activity and selectivity over IKK1 in parallel led to the discovery of 16, a potent and selective IKK2 inhibitor showing good ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c01094b7cd1f9f02ade498d99ac86e
https://doi.org/10.1016/j.bmcl.2012.06.065
https://doi.org/10.1016/j.bmcl.2012.06.065
Autor:
Jeremy John Payne, Geoff W. Mellor, Smith Kathryn Jane, Richard A. Williamson, Sebastien Andre Campos, Geoffrey J. Cutler, Caroline Whitworth, Mary A. Morse, Michael David Barker, Heather Hobbs, Rick P. C. Cousins, Duncan S. Holmes, Daniel Terence Tape, Paul Bamborough, John Martin Pritchard, John Liddle, Chris Ioannou
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(9)
The synthesis and SAR of a novel series of IKK2 inhibitors are described. Modification around the hinge binding region of the 7-azaindole led to a series of potent and selective inhibitors with good cellular activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac9d3089c47e68ac4f0cac67941fe59
https://pubmed.ncbi.nlm.nih.gov/19349179
https://pubmed.ncbi.nlm.nih.gov/19349179
Autor:
Paul F. Lambeth, Fiona S. Lucas, Richard Howard Green, Martin E. Swarbrick, Jeremy John Payne, Lee William Page, Malcolm Clive Carter, Paul John Beswick, Alexander J. Stevens, Sharon C Stratton, Neil Anthony Pegg, John Skidmore, Savvas Kleanthous, Alastair J. Stuart, Sue D. Collins, Sharon Bingham, John Andrew Corfield, Richard Stocker, Joanne O. Wiseman, C. David Hartley, Helen Susanne Price, Neil Mathews, Laura J. Chambers, Iain P. Chessell, Robert Gleave, Nick M. Clayton, Alan Naylor, C. Bountra
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
A novel series of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidine-based cyclooxygenase-2 (COX-2) inhibitors, which have a different arrangement of substituents compared to the more common 1,2-diarylheterocycle based molecules, have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadff8d23a6fefccadd5166b5ed7fd16
https://pubmed.ncbi.nlm.nih.gov/19520573
https://pubmed.ncbi.nlm.nih.gov/19520573