Development of a Cytopathic Effect-Based Phenotypic Screening Assay against Cryptosporidium

Autor: Alex Chao, Boon Heng Lee, Kah Fei Wan, David Beer, Peter Gedeck, Thierry T. Diagana, Jeremy J. Selva, Bin Zou, Ujjini H. Manjunatha, Ghislain M. C. Bonamy

Publikováno v: ACS Infectious Diseases. 4:635-645

Cryptosporidiosis is a diarrheal disease predominantly caused by Cryptosporidium parvum ( Cp) and Cryptosporidium hominis ( Ch), apicomplexan parasites which infect the intestinal epithelial cells of their human hosts. The only approved drug for cryp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3ddd4502b82cabe3c01150538fcfbb
https://doi.org/10.1021/acsinfecdis.7b00247

Responsiveness of sphingosine phosphate lyase insufficiency syndrome to vitamin B6 cofactor supplementation.

Autor: Zhao P; Department of Pediatrics, Division of Hematology/Oncology, University of California, San Francisco, California, USA., Liu ID; Department of Pediatrics, Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore., Hodgin JB; Department of Pathology, University of Michigan Hospitals and Health Center, Ann Arbor, Michigan, USA., Benke PI; SLING, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Selva J; SLING, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Torta F; SLING, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Wenk MR; SLING, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Endrizzi JA; Department of Pediatrics, Division of Hematology/Oncology, University of California, San Francisco, California, USA., West O; Department of Pediatrics, Division of Hematology/Oncology, University of California, San Francisco, California, USA., Ou W; Department of Pediatrics, Division of Hematology/Oncology, University of California, San Francisco, California, USA., Tang E; Department of Pediatrics, Division of Hematology/Oncology, University of California, San Francisco, California, USA., Goh DL; Department of Pediatrics, Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore., Tay SK; Department of Pediatrics, Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore., Yap HK; Department of Pediatrics, Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore., Loh A; Department of Pediatrics, Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore., Weaver N; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Sullivan B; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Division of Clinical Genetics, Children's Mercy Kansas City, Kansas City, Missouri, USA.; Department of Pediatrics, University of Missouri, Kansas City, Missouri, USA., Larson A; Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA., Cooper MA; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA., Alhasan K; Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Alangari AA; Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Salim S; Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Gumus E; Department of Medicine, Harran University, Sanliurfa, Turkey., Chen K; Department of Pediatrics, Division of Allergy and Immunology, University of Utah School of Medicine, Salt Lake City, Utah, USA., Zenker M; Institute of Human Genetics, Otto von Guericke University, Magdeburg, Germany., Hildebrandt F; Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA., Saba JD; Department of Pediatrics, Division of Hematology/Oncology, University of California, San Francisco, California, USA.

Publikováno v: Journal of inherited metabolic disease [J Inherit Metab Dis] 2020 Sep; Vol. 43 (5), pp. 1131-1142. Date of Electronic Publication: 2020 May 04.