Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jeremy J Ratiu"'
Autor:
Jeremy J. Ratiu, William E. Barclay, Elliot Lin, Qun Wang, Sebastian Wellford, Naren Mehta, Melissa J. Harnois, Devon DiPalma, Sumedha Roy, Alejandra V. Contreras, Mari L. Shinohara, David Wiest, Yuan Zhuang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
T cell development involves extensive proliferation of developing thymocytes. Here, the authors demonstrate that the transcription factor Zfp335 regulates the survival post-β-selection thymocytes via the cGAS/STING pathway.
Externí odkaz:
https://doaj.org/article/1986148c7cbb4df0b7b4c12b62079982
Autor:
Qi-Jing Li, Sumedha Roy, Yen-Yu Lin, Yue Xiong, Yuan Zhuang, Yanping Xu, Laura P. Hale, Jianxuan Wu, Qun Wang, Jeremy J. Ratiu, Baojun Zhang, Meifang Dai
Publikováno v:
Proceedings of the National Academy of Sciences. 117:28212-28220
Somatic mutations are major genetic contributors to cancers and many other age-related diseases. Many disease-causing somatic mutations can initiate clonal growth prior to the appearance of any disease symptoms, yet experimental models that can be us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47a97f3986a9a4b81d90f9318df867c9
https://doi.org/10.1073/pnas.2014308117
https://doi.org/10.1073/pnas.2014308117
Autor:
Jeremy J Ratiu, William Barclay, Qun Wang, Naren Mehta, Melissa J Harnois, Devon DiPalma, Sebastian Wellford, Sumedha Roy, Alejandra V Contreras, David Wiest, Yuan Zhuang
Production of a diverse peripheral T cell compartment requires massive expansion of the bone marrow progenitors that seed the thymus. There are two main phases of expansion during T cell development, following T lineage commitment at the DN2 stage an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2a60663eaa4b9d8992de715a524f621
https://doi.org/10.1101/2021.12.03.471158
https://doi.org/10.1101/2021.12.03.471158
Publikováno v:
The Journal of Immunology. 208:107.18-107.18
Production of a diverse peripheral T cell compartment requires massive expansion of the bone marrow progenitors that seed the thymus. There are two main phases of expansion during T cell development, following T lineage commitment at the DN2 stage an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e845a082c8952d71caf70a034959b597
https://doi.org/10.4049/jimmunol.208.supp.107.18
https://doi.org/10.4049/jimmunol.208.supp.107.18
Autor:
Isabel Stewart, Teresa P. DiLorenzo, Cathleen M Lutz, Kelsay Helm, Jeremy J. Ratiu, Jennifer Allocco, David V. Serreze, Jeremy J. Racine, Derry C. Roopenian, Yi-Guang Chen, Jennifer Schloss, Emily Lowell, Richard S Maser, Gregory J. Christianson
Publikováno v:
Diabetes. 67:923-935
Improved mouse models for type 1 diabetes (T1D) therapy development are needed. T1D susceptibility is restored to normally resistant NOD.β2m(−/−) mice transgenically expressing human disease–associated HLA-A*02:01 or HLA-B*39:06 class I molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e69dbecf07a48efc215b0dd7ed4ff81
https://doi.org/10.2337/db17-1467
https://doi.org/10.2337/db17-1467
Autor:
Vivek Philip, David V. Serreze, Clive Wasserfall, William H. Schott, Caroline M. Leeth, Jeremy J. Racine, Qiming Wang, Muneer G. Hasham, Harold D. Chapman, Kevin D. Mills, Jeremy J. Ratiu, Jing Zhu, Jane Branca, Mark A. Atkinson, Nina M Donghia
Publikováno v:
The Journal of Immunology. 198:4255-4267
B lymphocytes play a key role in type 1 diabetes (T1D) development by serving as a subset of APCs preferentially supporting the expansion of autoreactive pathogenic T cells. As a result of their pathogenic importance, B lymphocyte–targeted therapie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b091fc742d06983403144c9facd9089
https://doi.org/10.4049/jimmunol.1700024
https://doi.org/10.4049/jimmunol.1700024
Autor:
Estela Rosell-Mases, Jeremy J. Racine, Jorge Carrascal, Berta Arpa, Caroline M. Leeth, Qiming Wang, David V. Serreze, Leire Egia-Mendikute, Thomas Stratmann, Jorge Carrillo, Joan Verdaguer, Jeremy J. Ratiu, Harold D. Chapman
Publikováno v:
Diabetes
While the autoimmune destruction of pancreatic ß-cells underlying type 1 diabetes (1D) development is ultimately mediated by T-cells in NOD mice and also likely humans, B-lymphocytes play an additional key pathogenic role. It appears expression of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912a7613bf7a8f7e0c0f8e83c98ecc28
https://doi.org/10.2337/db15-1606
https://doi.org/10.2337/db15-1606
Autor:
Jennifer Allocco, Tim Stearns, Aron M. Geurts, Yi-Guang Chen, Maximiliano Presa, Ingo Schmitz, Deanna J. Lamont, Harold D. Chapman, David V. Serreze, Vishal Kumar Sarsani, Jennifer R. Dwyer, Jeremy J. Ratiu, Jeremy J. Racine
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950)
In both NOD mice and humans, the development of type 1 diabetes (T1D) is dependent in part on autoreactive CD8+ T cells recognizing pancreatic β cell peptides presented by often quite common MHC class I variants. Studies in NOD mice previously revea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3706ddd095e2b9a992612dbc351f4108
https://hdl.handle.net/10033/622048
https://hdl.handle.net/10033/622048
Autor:
Maximiliano, Presa, Jeremy J, Racine, Jennifer R, Dwyer, Deanna J, Lamont, Jeremy J, Ratiu, Vishal Kumar, Sarsani, Yi-Guang, Chen, Aron, Geurts, Ingo, Schmitz, Timothy, Stearns, Jennifer, Allocco, Harold D, Chapman, David V, Serreze
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 201(7)
In both NOD mice and humans, the development of type 1 diabetes (T1D) is dependent in part on autoreactive CD8(+) T-cells recognizing pancreatic ß-cell peptides presented by often quite common MHC class I variants. Studies in NOD mice previously rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2642363c4e8e868bad33016b3708f1ff
https://pubmed.ncbi.nlm.nih.gov/30127089
https://pubmed.ncbi.nlm.nih.gov/30127089
Autor:
Jennifer R. Dwyer, Jeremy J. Racine, Tim Stearns, Jeremy J. Ratiu, Maximiliano Presa, Vishal Kumar Sarsani, Jennifer Allocco, David V. Serreze, Ingo Schmitz, Deanna J. Lamont, Aron M. Geurts, Yi-Guang Chen, Harold D. Chapman
In both NOD mice and humans, the development of type 1 diabetes (T1D) is dependent in part on autoreactive CD8+ T-cells recognizing pancreatic ß-cell peptides presented by often quite common MHC class I variants. Studies in NOD mice previously revea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7e3f80f11bc6449fb2f90649ccd591