Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jeremy J Gam"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression but many quantitative aspects of miRNA biology remain to be elucidated. Based on a library of miRNA sensors, the authors quantify miRNA regulation at single cell leve
Externí odkaz:
https://doaj.org/article/9713160e9e0b4de492ec105715c1bd3d
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
In the originally published version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include support from the National Science Foundation (NSF), award number 1745645.
Externí odkaz:
https://doaj.org/article/558552b5a82d4fe6b2ccb5c68391b175
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature
Nature Communications
Nature
Nature Communications
MicroRNAs (miRNAs) regulate a majority of protein-coding genes, affecting nearly all biological pathways. However, the quantitative dimensions of miRNA-based regulation are not fully understood. In particular, the implications of miRNA target site lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694b37bca5b46a1dc243a779275a3195
https://doaj.org/article/9713160e9e0b4de492ec105715c1bd3d
https://doaj.org/article/9713160e9e0b4de492ec105715c1bd3d
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
MicroRNAs (miRNAs) regulate a majority of protein-coding genes, affecting nearly all biological pathways. However, the quantitative dimensions of miRNA-based regulation are not fully understood. In particular, the implications of miRNA target site lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c442854a81f2ffc50bd90bde3fcc71
http://europepmc.org/articles/PMC6214934
http://europepmc.org/articles/PMC6214934
A ‘poly-transfection’ method for rapid, one-pot characterization and optimization of genetic systems
Publikováno v:
Nucleic Acids Research
Biological research is relying on increasingly complex genetic systems and circuits to perform sophisticated operations in living cells. Performing these operations often requires simultaneous delivery of many genes, and optimizing the stoichiometry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b02fbb3fae86529927172663e37dd0
https://doi.org/10.1093/nar/gkz623
https://doi.org/10.1093/nar/gkz623
Autor:
David S. Kong, Ron Weiss, Scott T. Wick, Jeremy J Gam, Jonathan Babb, Todd Thorsen, Peter A. Carr
Publikováno v:
Nature
Microfluidic devices have the potential to automate and miniaturize biological experiments, but open-source sharing of device designs has lagged behind sharing of other resources such as software. Synthetic biologists have used microfluidics for DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ed707844944fea613d7b227413f14c
https://pubmed.ncbi.nlm.nih.gov/28591125
https://pubmed.ncbi.nlm.nih.gov/28591125
Autor:
Pascale R. Leroueil, Yuehua Zhang, Jeremy J. Gam, James R. Baker, Kyung Hoon Lee, Alina Kotlyar, Hong Zong, Thommey P. Thomas, Ming Hsin Li, Mark M. Banaszak Holl, Ankur Desai
Publikováno v:
Biomacromolecules. 13:982-991
Our group previously developed a multifunctional, targeted cancer therapeutic based on Generation 5 (G5) polyamidoamine (PAMAM) dendrimers. In those studies we conjugated the targeting molecule folic acid (FA) and the chemotherapeutic drug methotrexa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f31747bd040409ffffa390eb417f7a6
https://doi.org/10.1021/bm201639c
https://doi.org/10.1021/bm201639c
Autor:
Jeremy J. Gam, Christine M. Timmer, Bradford G. Orr, Seok-Ki Choi, Mark M. Banaszak Holl, Kumar Sinniah, James R. Baker, Amanda Witte
Publikováno v:
Biomacromolecules. 13:507-516
The present study describes the biophysical characterization of generation-five poly(amidoamine) (PAMAM) dendrimers conjugated with riboflavin (RF) as a cancer-targeting platform. Two new series of dendrimers were designed, each presenting the ribofl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e9f7b984d5f91d41492912c4fa1c05
https://doi.org/10.1021/bm201566g
https://doi.org/10.1021/bm201566g
Autor:
David S. Kong, Ron Weiss, Peter A. Carr, Scott T. Wick, Jeremy J Gam, Jonathan Babb, Todd Thorsen
Publikováno v:
Nature Biotechnology. 36:368-368
Nat. Biotechnol. 35, 523–529 (2017); published online 7 June 2017; corrected after print 28 February 2018 In the version of this article initially published, the wrong Creative Commons Attribution license (cc-by-nc rather than cc-by) was inserted.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e58f4801d580c2d145fbeb569557213b
https://doi.org/10.1038/nbt0418-368a
https://doi.org/10.1038/nbt0418-368a
Autor:
Jeremy J. Gam, Ankur Desai, Justin E. Silpe, Seok-Ki Choi, Alina Kotlyar, Thommey P. Thomas, Melvin Joice, Hong Zong, Baohua Huang, James R. Baker
Publikováno v:
Molecular pharmaceutics. 9(9)
Our previous studies have demonstrated that a generation 5 dendrimer (G5) conjugated with both folic acid (FA) and methotrexate (MTX) has a higher chemotherapeutic index than MTX alone. Despite this, batch-to-batch inconsistencies in the number of FA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93547df39a3fa722e57616ae7742c28d
https://pubmed.ncbi.nlm.nih.gov/22827500
https://pubmed.ncbi.nlm.nih.gov/22827500