Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jeremy J, Velazquez"'
Autor:
Dongshunyi Li, Jeremy J. Velazquez, Jun Ding, Joshua Hislop, Mo R. Ebrahimkhani, Ziv Bar-Joseph
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract A major advantage of single cell RNA-sequencing (scRNA-Seq) data is the ability to reconstruct continuous ordering and trajectories for cells. Here we present TraSig, a computational method for improving the inference of cell-cell interactio
Externí odkaz:
https://doaj.org/article/8b97f126d0ac4d28a579e15ac820ce67
Autor:
Patrick Guye, Mohammad R. Ebrahimkhani, Nathan Kipniss, Jeremy J. Velazquez, Eldi Schoenfeld, Samira Kiani, Linda G. Griffith, Ron Weiss
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
There has been limited success in generating tissues from human induced pluripotent stem cells (hiPSCs). Here, the authors genetically engineer expression of the transcription factor Gata6 in a single isogenic hiPSC population resulting in complex ti
Externí odkaz:
https://doaj.org/article/9b8be1df7dff49edbe97c27e4110a2e7
Publikováno v:
Transpl Int
Preoccupied with the astounding regenerative capabilities and metabolic importance of hepatocytes in the liver, the role of the resident "plumbers" of the liver, the cholangiocytes, can be overlooked in comparison. Cholangiocytes form the ductal netw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3fff42123d3df1247ebe77dbad4b4c7
https://doi.org/10.1111/tri.13902
https://doi.org/10.1111/tri.13902
Autor:
Jeremy J. Velazquez, Dongshunyi Li, Ziv Bar-Joseph, Jun Ding, Mo R. Ebrahimkhani, Joshua Hislop
A major advantage of single cell RNA-Sequencing (scRNA-Seq) data is the ability to reconstruct continuous ordering and trajectories for cells. To date, such ordering was mainly used to group cells and to infer interactions within cells. Here we prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45c4735b288c919a9b624d3dede710c8
https://doi.org/10.1101/2021.07.28.454054
https://doi.org/10.1101/2021.07.28.454054
Autor:
Farzaneh Moghadam, Yuqi Tan, Silvia Liu, Susana M. Chuva de Sousa Lopes, Mo R. Ebrahimkhani, Joseph C. Maggiore, Joshua Hislop, Jeremy J. Velazquez, Davy Cats, Patrick Cahan, Christopher L. Plaisier, Ryan LeGraw, Samira Kiani, Jacquelyn Kilbourne
Publikováno v:
Cell Systems, 12(1), 41-55.e11. Elsevier
Trends Genet
Trends Genet
Summary Pluripotent stem cell (PSC)-derived organoids have emerged as novel multicellular models of human tissue development but display immature phenotypes, aberrant tissue fates, and a limited subset of cells. Here, we demonstrate that integrated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef984817d983a940da7411dc9fc419ff
http://hdl.handle.net/1887/3280148
http://hdl.handle.net/1887/3280148
Publikováno v:
Methods in Molecular Biology ISBN: 9781071611739
Methods Mol Biol
Methods Mol Biol
Cell-fate determination is a function of cell-intrinsic and -extrinsic signaling cues. Understanding the design principles governing fate control in multicellular systems remains difficult to understand and analyze. To address the current challenges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25910863e8cfcf1900443e3fa2820f8
https://doi.org/10.1007/978-1-0716-1174-6_2
https://doi.org/10.1007/978-1-0716-1174-6_2
Autor:
Jeremy J. Velazquez, Shi Tong Liu, Jacquelyn Kilbourne, Farzaneh Moghadam, Christopher L. Plaisier, Yuqi Tan, Ryan LeGraw, Mo R. Ebrahimkhani, Davy Cats, Susana M. Chuva de Sousa Lopes, Joshua Hislop, Samira Kiani, Patrick Cahan
SUMMARYPluripotent stem cell (PSC)-derived organoids are emerging as novel human-based microphysiological models but display immature phenotypes with limited subsets of endothelial or stromal cells. Here we demonstrate that in vitro manipulation of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90a728c6249b275459fecc216928cf9
Autor:
Jin Park, Samira Kiani, Ryan LeGraw, Farzaneh Moghadam, Chenxi Xu, Mo R. Ebrahimkhani, Jeremy J. Velazquez, Alejandro Chavez, Nan Cher Yeo
Publikováno v:
Nature cell biology
Transient modulation of the genes involved in immunity, without exerting a permanent change in the DNA code, can be an effective strategy to modulate the course of many inflammatory conditions. CRISPR-Cas9 technology represents a promising platform f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dee67a6c4a1abc88f496287780614ce
https://pubmed.ncbi.nlm.nih.gov/32884147
https://pubmed.ncbi.nlm.nih.gov/32884147
Autor:
Jeremy J. Velazquez, Jacob C. Ulirsch, Alejandra Macias-Garcia, Stuart S. Levine, Vijay G. Sankaran, Jung-Kuei Chen, Shupei Zhang, Vincent L. Butty
Iron and heme play central roles in red blood cell production. However, the mechanisms by which iron and heme levels coordinate erythropoiesis remain incompletely understood. HRI is a heme-regulated kinase that controls translation by phosphorylating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1cf65916971dddf80865b9ee4f3cb62
https://doi.org/10.1101/408054
https://doi.org/10.1101/408054
Autor:
Collin D. Edington, Wen Li Kelly Chen, Emily Geishecker, Timothy Kassis, Luis R. Soenksen, Brij M. Bhushan, Duncan Freake, Jared Kirschner, Christian Maass, Nikolaos Tsamandouras, Jorge Valdez, Christi D. Cook, Tom Parent, Stephen Snyder, Jiajie Yu, Emily Suter, Michael Shockley, Jason Velazquez, Jeremy J. Velazquez, Linda Stockdale, Julia P. Papps, Iris Lee, Nicholas Vann, Mario Gamboa, Matthew E. LaBarge, Zhe Zhong, Xin Wang, Laurie A. Boyer, Douglas A. Lauffenburger, Rebecca L. Carrier, Catherine Communal, Steven R. Tannenbaum, Cynthia L. Stokes, David J. Hughes, Gaurav Rohatgi, David L. Trumper, Murat Cirit, Linda G. Griffith
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-18 (2018)
Scientific Reports
Scientific Reports
Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion. Here, we report an approach to co-culture multiple dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4741b36a46f0d7bf6aad597469216ff
https://doi.org/10.1038/s41598-018-22749-0
https://doi.org/10.1038/s41598-018-22749-0