Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jeremy G. Dain"'
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 40(9)
The metabolism, pharmacokinetics, and excretion of [(14)C]indacaterol were investigated in healthy male subjects. Although indacaterol is administered to patients via inhalation, the dose in this study was administered orally. This was done to avoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5602c1f1979098cab24217d854c31f3
https://pubmed.ncbi.nlm.nih.gov/22648561
https://pubmed.ncbi.nlm.nih.gov/22648561
Publikováno v:
Pharmaceutical Research. 11:925-928
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c2803be86e9fd3c94606ac4cf3c23ad
https://doi.org/10.1023/a:1018958631158
https://doi.org/10.1023/a:1018958631158
Autor:
Dario A. Otero, Philip A. Bell, Jeremy G. Dain, Thomas Daniel Aicher, Jeffrey Nadelson, Robert J. Strohschein, Leonard J. Brand, Douglas C. Knorr, James E. Foley, Douglas A. Young, Gregory Raymond Bebernitz, Ronald Simpson, William S. Fillers, Rhonda O. Deems
Publikováno v:
Journal of medicinal chemistry. 42(1)
SAH 51-641 (1) is a potent hypoglycemic agent, which acts by inhibiting hepatic gluconeogenesis. It is a prodrug of 4-(2, 2-dimethyl-1-oxopropyl)benzoic acid (2) and 4-(2, 2-dimethyl-1-hydroxypropyl)benzoic acid (3), which sequester coenzyme A (CoA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744d8ab1f1a528d95ddc2bf1adb00384
https://pubmed.ncbi.nlm.nih.gov/9888840
https://pubmed.ncbi.nlm.nih.gov/9888840
Publikováno v:
Biopharmaceuticsdrug disposition. 16(3)
The disposition of [3H]fluvastatin was examined following single oral doses in dogs (12.4 mg kg-1) and monkeys (0.48 and 45.5 mg kg-1) with bile fistulae. Serial plasma and complete urine, feces, and bile were collected at designated intervals for 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399df3e3cd5b469752ffb358a988d765
https://pubmed.ncbi.nlm.nih.gov/7787133
https://pubmed.ncbi.nlm.nih.gov/7787133
Autor:
Jeremy G. Dain, W R Simpson, Robert J. Strohschein, Gregory Raymond Bebernitz, Rhonda O. Deems, Dario A. Otero
Publikováno v:
Journal of Medicinal Chemistry. 45:1150-1150
The overproduction of glucose by the liver in NIDDM patients markedly contributes to their fasting hyperglycemia and is a direct consequence of the increased oxidation of excess free fatty acids (FFA) being released from the adipocyte. 2-(1,1-Dimethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ca9d7de3bb24b33475af3d96b7d45c
https://doi.org/10.1021/jm010571h
https://doi.org/10.1021/jm010571h
Autor:
Jeremy G. Dain
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 24:499-504
Temazepam-2-14C, 7-Chloro-1,3,-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one-2-14C, was prepared in a five-step synthesis. Chloroacetic-1-14C acid was converted to the acid chloride with thionyl chloride. The acid chloride was allowe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::562e5d04fa5d7ad7cde74e20585ed788
https://doi.org/10.1002/jlcr.2580240504
https://doi.org/10.1002/jlcr.2580240504
Publikováno v:
The Journal of Clinical Pharmacology. 24:47-57
The pharmacokinetics of 4-[(3-methoxyphenyl)methyl] -2,2,6,6-tetramethyl-1-oxa-4-aza-2,6-disilacyclohexane (Sandoz compound 58-112), a new chemical entity with a unique myotonolytic effect, was studied in 12 healthy male volunteers who received an or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9690bdd8e8fd83d221e2f6bed0d64a6
https://doi.org/10.1002/j.1552-4604.1984.tb01813.x
https://doi.org/10.1002/j.1552-4604.1984.tb01813.x
Autor:
Jeremy G. Dain, Bernard T. Gillis
Publikováno v:
The Journal of Organic Chemistry. 36:518-521
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba2914e2761559768ef4508b5f30ae23
https://doi.org/10.1021/jo00803a006
https://doi.org/10.1021/jo00803a006
Autor:
Jeremy G. Dain, Ronald Bentley
Publikováno v:
Bioorganic Chemistry. 1:374-379
Mycobacterium phlei has been shown by tracer techniques to utilize malonate in the biosynthesis of 6-methylsalicylic acid. The labeling pattern of 6-methylsalicylic acid obtained by chemical degradation is consistent with the acetate polymalonate bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dab9f9eb559db1d3be62ca309cfdb1b6
https://doi.org/10.1016/0045-2068(71)90040-x
https://doi.org/10.1016/0045-2068(71)90040-x
Autor:
Bernard T. Gillis, Jeremy G. Dain
Publikováno v:
Journal of Heterocyclic Chemistry. 8:339-339
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58c8afd26a66d08ef4cfb6752c528f83
https://doi.org/10.1002/jhet.5570080237
https://doi.org/10.1002/jhet.5570080237