Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Jeremy G, Owen"'
Autor:
Peng Hou, Vincent V. Nowak, Chanel J. Taylor, Mark J. Calcott, Allison Knight, Jeremy G. Owen
Publikováno v:
mSystems, Vol 8, Iss 2 (2023)
ABSTRACT Actinomycetes are prolific producers of industrially valuable and medically important compounds. Historically, the most efficient method of obtaining compounds has been bioactivity-guided isolation and characterization of drug-like molecules
Externí odkaz:
https://doaj.org/article/fe7a14c330e647c58c37aae6bec0848f
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Non-ribosomal peptide synthases are multimodular enzymes comprised of adenylation (A), condensation (C) and thiolation domains. Here, the authors show that non-ribosomal peptides can be generated solely by A domain substitutions, providing evidence t
Externí odkaz:
https://doaj.org/article/48924e1b8e5f493994a0d6dff8b81874
Autor:
Vincent Libis, Niv Antonovsky, Mengyin Zhang, Zhuo Shang, Daniel Montiel, Jeffrey Maniko, Melinda A. Ternei, Paula Y. Calle, Christophe Lemetre, Jeremy G. Owen, Sean F. Brady
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Soil microorganisms are a rich source of bioactive molecules. Here, the authors present a targeted sequencing workflow that reconstructs the clustered organization of biosynthetic domains in metagenomic libraries from amplicon data, thus guiding the
Externí odkaz:
https://doaj.org/article/2be2b1b1e1544062afa735e20fcd1c7b
Autor:
Peng Hou, V. Helen Woolner, Joe Bracegirdle, Patricia Hunt, Robert A. Keyzers, Jeremy G. Owen
Publikováno v:
Journal of Natural Products. 86:526-532
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46b5e9803aee9e4d30d727ed13e535da
https://doi.org/10.1021/acs.jnatprod.2c00801
https://doi.org/10.1021/acs.jnatprod.2c00801
Autor:
Mathew A. Storey, Sarah K. Andreassend, Joe Bracegirdle, Alistair Brown, Robert A. Keyzers, David F. Ackerley, Peter T. Northcote, Jeremy G. Owen
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Marine sponges have been a prolific source of unique bioactive compounds that are presumed to act as a deterrent to predation. Many of these compounds have potential therapeutic applications; however, the lack of efficient and sustainable sy
Externí odkaz:
https://doaj.org/article/94c3f8add06a48ba9ee2fb71c7a960c2
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 1066 (2021)
A recently-validated and underexplored drug target in Mycobacterium tuberculosis is PptT, an essential phosphopantetheinyl transferase (PPTase) that plays a critical role in activating enzymes for both primary and secondary metabolism. PptT possesses
Externí odkaz:
https://doaj.org/article/b870eb6d4c1a4c61969570b604b5c562
Autor:
Michelle H Rich, Abigail V Sharrock, Timothy S Mulligan, Frazer Matthews, Alistair S Brown, Hannah R Lee-Harwood, Elsie M Williams, Janine N Copp, Rory F Little, Jenni JB Francis, Claire N Horvat, Luke J Stevenson, Jeremy G Owen, Meera T Saxena, Jeff S Mumm, David F Ackerley
Publikováno v:
bioRxiv
SummaryFunctional screening of environmental DNA (eDNA) libraries is a potentially powerful approach to discover enzymatic “unknown unknowns”, but is usually heavily biased toward the tiny subset of genes preferentially transcribed and translated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a912240b02a0284245439c0f64bc50dc
https://doi.org/10.1101/2023.03.24.534183
https://doi.org/10.1101/2023.03.24.534183
Publikováno v:
Marine Drugs, Vol 18, Iss 7, p 337 (2020)
Global natural products social (GNPS) molecular networking is a useful tool to categorize chemical space within samples and streamline the discovery of new natural products. Here, we demonstrate its use in chemically profiling the extract of the mari
Externí odkaz:
https://doaj.org/article/0446c41c1c77449aae840751ec9e8c5d
Publikováno v:
Methods in Molecular Biology ISBN: 9781071632130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb813ec9ebd966aafeec61883d3d5a47
https://doi.org/10.1007/978-1-0716-3214-7_7
https://doi.org/10.1007/978-1-0716-3214-7_7
Autor:
Vincent V. Nowak, Peng Hou, David F. Ackerley, Robert A. Keyzers, Joe Bracegirdle, Jeremy G. Owen
Publikováno v:
Journal of Natural Products. 84:2536-2543
The skyllamycins are a class of heavily modified, non-ribosomal peptides, first isolated from Streptomyces sp. KY11784. A Streptomyces strain with potent antibiotic activity against Bacillus subtilis was isolated from a sample of the New Zealand lich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbc4d67faa25807a63faf945694f4b3f
https://doi.org/10.1021/acs.jnatprod.1c00547
https://doi.org/10.1021/acs.jnatprod.1c00547