Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jeremy Fordham"'
Autor:
Jacqui Lockey, Klaus Lindauer, Ray Jupp, Elizabeth Allen, Ian Hayes, Hans-Christoph Schneider, Roger Temple, Kenny Pollock, Simon Phipps, Jeremy Fordham
Publikováno v:
Scopus-Elsevier
The increase in eosinophils at the site of antigen challenge has been used as evidence to suggest that this cell type plays a role in the pathophysiology of asthma. Aberrant production of several different cytokines, particularly interleukin (IL)-5,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b438c33f524a4638f6851c88e9f88974
https://doi.org/10.1165/ajrcmb.25.4.4456
https://doi.org/10.1165/ajrcmb.25.4.4456
Autor:
Mei S. Duguid, Jurcak John G, Ram Dharanipragada, Rachel Wang, Matthew A. Smicker, Kwon Yon Musick, Xiping Bi, Ashfaq Parkar, Jane Peppard, Ying Zhang, Zhicheng Zhao, Nisha Zaidi, Choi Yong-Mi, Jeremy Fordham, Gillespy Timothy Alan, Dorothea Kominos, Matthieu Barrague, Larry R. McLean
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(9)
Beginning with a screening hit, unique thienopyrazole-indole inhibitors of Itk (interleukin-2-inducible tyrosine kinase) were designed, synthesized, and crystallized in the target kinase. Although initial compounds were highly active in Itk, they wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7571214176f5282eafced780512a7d95
https://pubmed.ncbi.nlm.nih.gov/22464456
https://pubmed.ncbi.nlm.nih.gov/22464456
Autor:
Roy J. Vaz, Larry R. McLean, Ying Zhang, Hua Li, Yi Li, Joy Prisco, Ziyu Li, Choi Yong-Mi, Joseph T. Tsay, Zuoning Han, Stephan Reiling, Ulrike Lukasczyk, Jeremy Fordham
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(23)
Biochemical and X-ray crystallographic studies confirmed that hydroxyquinoline derivatives identified by virtual screening were actually covalent inhibitors of the MIF tautomerase. Adducts were formed by N-alkylation of the Pro-1 at the catalytic sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd383e8d558cc5b0cf5ee20754de94e
https://pubmed.ncbi.nlm.nih.gov/19836948
https://pubmed.ncbi.nlm.nih.gov/19836948