Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jeremy F. Atherton"'
Autor:
Joshua W. Callahan, Juan Carlos Morales, Jeremy F. Atherton, Dorothy Wang, Selena Kostic, Mark D. Bevan
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114495- (2024)
Summary: The subthalamic nucleus (STN) is traditionally thought to restrict movement. Lesion or prolonged STN inhibition increases movement vigor and propensity, while optogenetic excitation has opposing effects. However, STN neurons often exhibit mo
Externí odkaz:
https://doaj.org/article/f1430c32f4eb4c638e490d4bc07fceed
Autor:
Jeremy F Atherton, Eileen L McIver, Matthew RM Mullen, David L Wokosin, D James Surmeier, Mark D Bevan
Publikováno v:
eLife, Vol 5 (2016)
The subthalamic nucleus (STN) is an element of cortico-basal ganglia-thalamo-cortical circuitry critical for action suppression. In Huntington's disease (HD) action suppression is impaired, resembling the effects of STN lesioning or inactivation. To
Externí odkaz:
https://doaj.org/article/1ce7a2909744475281264f266529e3b2
Autor:
Jyothisri Kondapalli, Eileen L. McIver, Hong Yuan Chu, D. James Surmeier, Jeremy F. Atherton, Mark D. Bevan, David L. Wokosin, Kathleen E. Cosgrove
Highlightsdecorrelating autonomous STN activity was downregulated in both toxin and genetic models of PDelevation of D2-striatal projection neuron transmission was sufficient for downregulationdownregulation was dependent on activation of STN NMDA re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0adb48b6498dc6b1231ae19a402b8aba
https://doi.org/10.1101/385443
https://doi.org/10.1101/385443
Publikováno v:
Mov Disord
SummaryThe two principal movement-suppressing pathways of the basal ganglia, the so-called hyperdirect and indirect pathways, interact within the subthalamic nucleus (STN). An appropriate level and pattern of hyperdirect pathway cortical excitation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6a159d83206543bcc6f18911e0719e
Autor:
Hong Yuan Chu, David L. Wokosin, D. James Surmeier, Mark D. Bevan, Eileen L. McIver, Jeremy F. Atherton, Jyothisri Kondapalli, Kathleen E. Cosgrove
Publikováno v:
Cell reports
SUMMARY Abnormal subthalamic nucleus (STN) activity is linked to impaired movement in Parkinson’s disease (PD). The autonomous firing of STN neurons, which contributes to their tonic excitation of the extrastriatal basal ganglia and shapes their in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2192a90aeed28404a763801bc28393
http://europepmc.org/articles/PMC6699776
http://europepmc.org/articles/PMC6699776
Publikováno v:
The Journal of Neuroscience. 33:7130-7144
The frequency and pattern of activity in the reciprocally connected GABAergic external globus pallidus (GPe) and glutamatergic subthalamic nucleus (STN) are closely related to motor function. Although phasic, unitary GPe–STN inputs powerfully patte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7375c1b0130046094627469b417c4a0c
https://doi.org/10.1523/jneurosci.3576-12.2013
https://doi.org/10.1523/jneurosci.3576-12.2013
Publikováno v:
The Journal of Neuroscience. 29:15531-15541
Burst firing of substantia nigra dopamine (SN DA) neurons is believed to represent an important teaching signal that instructs synaptic plasticity and associative learning. However, the mechanisms through which synaptic excitation overcomes the limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57dcb9bdd9610f07745ab0fb7ee0f93
https://doi.org/10.1523/jneurosci.2961-09.2009
https://doi.org/10.1523/jneurosci.2961-09.2009
Publikováno v:
The Journal of Physiology. 586:5679-5700
The activity of the subthalamic nucleus (STN) is intimately related to movement and is generated, in part, by voltage-dependent Na(+) (Na(v)) channels that drive autonomous firing. In order to determine the principles underlying the initiation and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3248e436b2f2c768d59fd822ea4f311f
https://doi.org/10.1113/jphysiol.2008.155861
https://doi.org/10.1113/jphysiol.2008.155861
Publikováno v:
The Journal of Physiology. 586:817-833
The autonomous firing pattern of neurons in the rat subthalamic nucleus (STN) is shaped by action potential afterhyperpolarization currents. One of these is an apamin-sensitive calcium-dependent potassium current (SK). The duration of SK current is u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b76a5395c3d547ef05db1d9f16f20674
https://doi.org/10.1113/jphysiol.2007.141929
https://doi.org/10.1113/jphysiol.2007.141929