Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jeremy Dennison"'
Autor:
Brandon Swift, Lee Crossman, Graeme Young, Robin L. O'Connor-Semmes, Megan M. McLaughlin, David Kenworthy, David A. Bershas, Matthew Allinder, Jill L. Pirhalla, Mitesh Sanghvi, Maciej J. Zamek-Gliszczynski, Karl M. Thorpe, Jeremy Dennison, Jennypher Mudunuru, Adrian Pereira
Publikováno v:
Drug Metabolism and Disposition. 49:1109-1117
Linerixibat, an oral small molecule ileal bile acid transporter inhibitor under development for cholestatic pruritus in primary biliary cholangitis, was designed for minimal intestinal absorption (site of pharmacological action). This study character
Autor:
Naoki Honda, Jeremy Dennison, Dominic Beale, Malcolm Boyce, Francesca Mazzo, Paul Smith, Mark Bruce
Publikováno v:
British Journal of Clinical Pharmacology
Aims The objectives of this study were to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of ONO-7684, a novel activated factor XI (FXIa) inhibitor, in healthy subjects. Methods This was a
Autor:
Saidee J. Hyder, Dustin F. Garig, Robert Colvin, Brian R. Kreiser, Sarah C. Sweat, Luke Pearson, Taylor Simmonds, Andrew J. Feltmann, Joshua R. Ennen, Jeremy Dennison, Jon M. Davenport
Publikováno v:
Chelonian Conservation and Biology. 20
Western alligator snapping turtles, Macrochelys temminckii, have experienced population declines throughout most of their distribution. The present study is the first to systematically sample aquatic habitats of western Tennessee to assess the status
Autor:
Andrew J Pollard, Odile Launay, Jean-Daniel Lelievre, Christine Lacabaratz, Sophie Grande, Neil Goldstein, Cynthia Robinson, Auguste Gaddah, Viki Bockstal, Aurelie Wiedemann, Maarten Leyssen, Kerstin Luhn, Laura Richert, Christine Bétard, Malick M Gibani, Elizabeth A Clutterbuck, Matthew D Snape, Yves Levy, Macaya Douoguih, Rodolphe Thiebaut, Christopher McShane, Benoit Callendret, Stephanie Dincq, Camille Ferrault, Siew Pin Chai, Maire Paule Gyselen, Marleen van Looveren, Sylvia van Ballert, Tinne de Cnodder, Len Roza, Chiara Forcheh, Kate Stevens, Carmela Mastrandrea, Sanne de Ridder, Rachana Gundluru, Nathalie Swales, Vanessa Errijegers, Wouter Willems, Veronika Roorda, Nicola Orzabal, Magdalena Assenberg, Karine Vialatte, Frédéric Remblier, Elodie Porcar, Anton Ottavi, Eugénie Destandau, Christine Schwimmer, Laetitia Moinot, Cédrick Wallet, Florence Allais, Hélène Savel, Naouel Nedjaai, Anaïs Maugard, Nehza Lenzi, Pierre Loulergue, Mathilde Bahuaud, Fabrice Lainé, Bruno Laviolle, Nolwenn Boissel, Elise Thébault, David Vallée, Jean-François Nicolas, Sophie Gilbert, Karima Dahel, Karen Sagorny, Frédéric Lucht, Stéphane Paul, Alice Haccourt Chanavat, Florent Charra, Catherine Mutter, Monique Lambour, Caroline Muller, Anne Hutt-Clauss, Olivia Aranda, Louis Bernard, Valérie Gissot, Marie-Charlotte Hallouin-Bernard, Alain Goudeau, Steve Suzzoni, Eva Auostin, Lysiane Brick, Jose-Luis Lopez-Zaragoza, Giovanna Melic, Murial Carvalho, Chrystel Chesnel, Hakim Hocini, Aurélie Wiedemann, Laurent Hanot, Véronique Rieux, Adeep Puri, Temitope Adeloye, Malcolm Boyce, Jeremy Dennison, Inge Loewenstein, Omar Sahgal, Frans van den Berg, Wendy Calvert, Mary Faldon, Bruce McClain, Marie-Lousie Newell, Geert Molenberghs
Publikováno v:
The Lancet Infectious Diseases
The Lancet Infectious Diseases, New York, NY : Elsevier Science ; The Lancet Pub. Group, 2001-, 2020, ⟨10.1016/S1473-3099(20)30476-X⟩
The Lancet Infectious Diseases, New York, NY : Elsevier Science ; The Lancet Pub. Group, 2001-, 2020, ⟨10.1016/S1473-3099(20)30476-X⟩
Summary Background To address the unmet medical need for an effective prophylactic vaccine against Ebola virus we assessed the safety and immunogenicity of three different two-dose heterologous vaccination regimens with a replication-deficient adenov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43c24659b62a3ec06bc9708186876d5
http://hdl.handle.net/20.500.12278/26684
http://hdl.handle.net/20.500.12278/26684
Autor:
Sabine Specht, Natalie Strub-Wourgaft, Heino Stass, Belen Pedrique, Jeremy Dennison, Karen Dequatre-Cheeseman, Frans van den Berg, Sophie Delhomme, Frédéric Monnot, Claudia Peña-Rossi, Susanne Skrabs, Jean-Yves Gillon, Maria-Luisa Rodriguez
Aims: Emodepside is an anthelmintic, originally developed for veterinary use. We investigated the safety, pharmacokinetics, relative bioavailability and dose linearity of four oral formulations of emodepside in healthy male subjects. Methods: Three r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f70ac7813971a74eb5028e30b0fa036b
https://doi.org/10.22541/au.159863472.25422049
https://doi.org/10.22541/au.159863472.25422049
Autor:
Stephen J. Baker, Nathalie Hopchet, Jeremy Dennison, Graeme Young, Shuying Yang, Andrew W Harrell, Andy Gillies, Amanda Oliver, Frans van den Berg, David C Starbuck, Etienne Dumont, Vijayalakshmi Chandrasekaran, Anirban Lahiry, Alex Georgiou, Chris Ioannou, Julia Billiard
Publikováno v:
Antimicrobial Agents and Chemotherapy
Chronic obstructive pulmonary disease (COPD) is an inflammatory lung condition, causing progressive decline in lung function leading to premature death. Acute exacerbations in COPD patients are predominantly associated with respiratory viruses. Ribav
Autor:
Atholl Johnston, Omair Sahgal, Temitope Adeloye, Adeep Puri, Jeremy Dennison, Steve Warrington, Takamasa Endo
Publikováno v:
Clinical Pharmacology in Drug Development
Amenamevir (formerly ASP2151) is a helicase‐primase inhibitor being developed for the treatment of herpesvirus infection. Amenamevir is both a substrate and inducer of cytochrome P450 (CYP) 3A4. Three studies were done in healthy volunteers to inve
Publikováno v:
Clinical Pharmacology in Drug Development
Amenamevir (formerly ASP2151) induces cytochrome P450 (CYP)2B6 and CYP3A4 and inhibits CYP2C8. We conducted 2 studies, 1 using montelukast as a probe to assess CYP2C8 and the other bupropion to assess CYP2B6. The montelukast study examined the effect