Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jeremy D. Grevet"'
Autor:
Ross C. Hardison, Gerd A. Blobel, Zhe Zhang, Junwei Shi, Xianjiang Lan, Eugene Khandros, Peng Huang, Osheiza Abdulmalik, Jeremy D. Grevet, Carly L. Geronimo, Cheryl A. Keller, Belinda Giardine, Scott A. Peslak
Publikováno v:
Blood Adv
Increasing fetal hemoglobin (HbF) provides clinical benefit in patients with sickle cell disease (SCD). We recently identified heme-regulated inhibitor (HRI, EIF2AK1), as a novel HbF regulator. Because HRI is an erythroid-specific protein kinase, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aaa084bf9e3f779e750f035faadc8c8
https://doi.org/10.1182/bloodadvances.2020002475
https://doi.org/10.1182/bloodadvances.2020002475
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
Autor:
Ross C. Hardison, Saurabh K. Bhardwaj, Carolyne J. Face, Stella T. Chou, Christopher R. Edwards, Stephen A. Liebhaber, Gerd A. Blobel, Xianjiang Lan, Ben A. Garcia, Junwei Shi, Laavanya Sankaranarayanan, David Posocco, Simone Sidoli, Belinda Giardine, Nicole Hamagami, Osheiza Abdulmalik, Jeremy D. Grevet, Cheryl A. Keller, Xinjun Ji
Publikováno v:
Science. 361:285-290
A CRISPR screen for RBC regulators Hemoglobin in red blood cells (RBCs) carries oxygen to the tissues. Sickle cell disease is an inherited condition that involves abnormal hemoglobin. Current treatments entail modulating the level of fetal hemoglobin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5109cfea70f05b8aa327d5970f3421e6
https://doi.org/10.1126/science.aao0932
https://doi.org/10.1126/science.aao0932
Autor:
Gerd A. Blobel, Jim R. Hughes, Cheryl A. Keller, Belinda Giardine, James O.J. Davies, Jeremy D. Grevet, Ryo Kurita, Ross C. Hardison, Peng Huang, Yukio Nakamura
Chromatin structure is tightly intertwined with transcription regulation. Here we compared the chromosomal architectures of fetal and adult human erythroblasts and found that, globally, chromatin structures and compartments A/B are highly similar at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10997500530e057f4866df62f94809c0
https://ora.ox.ac.uk/objects/uuid:2363a4b5-17c0-41fb-8498-e54a603df1f4
https://ora.ox.ac.uk/objects/uuid:2363a4b5-17c0-41fb-8498-e54a603df1f4
Autor:
Ross C. Hardison, Osama El Demerdash, Cheryl A. Keller, Xiaoli S. Wu, Belinda Giardine, Emily R. Duffner, Eugene Khandros, Xianjiang Lan, Benjamin A. Garcia, Jeremy D. Grevet, Osheiza Abdulmalik, Hongxin Wang, Gerd A. Blobel, Christopher R. Vakoc, Saurabh K. Bhardwaj, Junwei Shi, Scott A. Peslak, Peng Huang, Josue Baeza
Publikováno v:
Blood advances. 3(10)
Reactivation of fetal hemoglobin (HbF) production benefits patients with sickle cell disease and β-thalassemia. To identify new HbF regulators that might be amenable to pharmacologic control, we screened a protein domain–focused CRISPR-Cas9 librar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf816b8159b621cf9249cdcfd7b4ed7
https://pubmed.ncbi.nlm.nih.gov/31126914
https://pubmed.ncbi.nlm.nih.gov/31126914
Autor:
Nicholas Aboreden, Merlin Crossley, Ren Ren, Thiyagaraj Mayuranathan, Xianjiang Lan, Jeremy D. Grevet, Osheiza Abdulmalik, Kunhua Qin, Yemin Lan, Cheryl A. Keller, Gerd A. Blobel, Zhe Zhang, Mitchell J. Weiss, John R. Horton, Ruopeng Feng, Xiaodong Cheng, Belinda Giardine, Junwei Shi, Ross C. Hardison, Lana C. Ly
Publikováno v:
Mol Cell
Transcription factors typically regulate a large number of genes. Here we found that transcription factor ZNF410 binds and activates the expression of a single direct target gene, CHD4, to enforce the silencing of the fetal hemoglobin genes (HBG1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6372c6e0d4ee7a67499645dd714ae0f
https://doi.org/10.1182/blood-2020-137564
https://doi.org/10.1182/blood-2020-137564
Publikováno v:
Blood. 134:966-966
Elevated levels of fetal hemoglobin (HbF) can alleviate symptoms of hemoglobinopathies, such as sickle cell disease (SCD). Hydroxyurea is the only FDA approved drug that works through this mechanism of HbF induction; however, its efficacy is variable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::130024b7724db1926900b16d3976ccfd
https://doi.org/10.1182/blood-2019-125901
https://doi.org/10.1182/blood-2019-125901
Publikováno v:
Journal of Biological Chemistry. 288:6140-6153
CALHM1 (calcium homeostasis modulator 1) forms a plasma membrane ion channel that mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration. Six human CALHM homologs exist with no homology to other proteins, although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c28905f9f838675fe6c91ceb75010dc
https://doi.org/10.1074/jbc.m112.409789
https://doi.org/10.1074/jbc.m112.409789
Autor:
Ville Leinonen, Donna Dello Iacono, Lata G. Menon, Juha E. Jääskeläinen, Jeremy D. Grevet, Peter McL. Black, Rona S. Carroll
Publikováno v:
International Journal of Alzheimer's Disease
International Journal of Alzheimer's Disease, Vol 2011 (2011)
International Journal of Alzheimer's Disease, Vol 2011 (2011)
The diagnosis of idiopathic normal pressure hydrocephalus (iNPH) is still challenging. Alzheimer's disease (AD), along with vascular dementia, the most important differential diagnosis for iNPH, has several potential cerebrospinal fluid (CSF) biomark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18960131bc80251d6b67661964e19b38
https://doi.org/10.4061/2011/312526
https://doi.org/10.4061/2011/312526
Autor:
Junwei Shi, Gerd A. Blobel, Eugene Khandros, Xianjiang Lan, Ross C. Hardison, Scott A. Peslak, Jeremy D. Grevet, Belinda Giardine, Ben A. Garcia, Cheryl A. Keller, Saurabh K. Bhardwaj
Publikováno v:
Blood. 132:414-414
Elevated levels of fetal hemoglobin (HbF) are beneficial to patients with sickle cell disease (SCD) and b-thalassemia. The identification of pharmacologically controllable pathways that regulate HbF levels remains an important goal in the treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d732a926d5300194f9361b8b8adf7c0
https://doi.org/10.1182/blood-2018-99-119518
https://doi.org/10.1182/blood-2018-99-119518
Autor:
Gerd A. Blobel, Junwei Shi, Xianjiang Lan, Jeremy D. Grevet, Osheiza Abdulmalik, Scott A. Peslak
Publikováno v:
Blood. 132:721-721
Increasing fetal hemoglobin (HbF) provides significant clinical benefit for patients with sickle cell disease (SCD) and is a critical goal that is being pursued with a variety of pharmacologic strategies. Hydroxyurea (HU) is currently the only FDA-ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::063d1d8bbeaca7cb47ddbefb4ee7fad8
https://doi.org/10.1182/blood-2018-99-117436
https://doi.org/10.1182/blood-2018-99-117436