Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jeremy D. Eastwood"'
Autor:
Tsung-Han Chou, Zixuan Hao, Diego Alba, Angelina Lazo, Gabriele Gallo Afflitto, Jeremy D. Eastwood, Vittorio Porciatti, John Guy, Hong Yu
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 17068 (2023)
Leber’s hereditary optic neuropathy (LHON) is a common mitochondrial genetic disease, causing irreversible blindness in young individuals. Current treatments are inadequate, and there is no definitive cure. This study evaluates the effectiveness of
Externí odkaz:
https://doaj.org/article/008312915d954d5db99727ffe44c89e7
Autor:
Sindhu Velmurugan, Tsung-Han Chou, Jeremy D. Eastwood, Vittorio Porciatti, Yuan Liu, William W. Hauswirth, John Guy, Hong Yu
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionTherapies for Leber hereditary optic neuropathy (LHON), in common with all disorders caused by mutated mitochondrial DNA, are inadequate. We have developed two gene therapy strategies for the disease: mitochondrial-targeted and allotopic
Externí odkaz:
https://doaj.org/article/024aabcbb22546efaaa4cc2fc2fb0bfa
Autor:
Yuan Liu, Jeremy D. Eastwood, Diego E. Alba, Sindhu Velmurugan, Ning Sun, Vittorio Porciatti, Richard K. Lee, William W. Hauswirth, John Guy, Hong Yu
Publikováno v:
Gene therapy. 29(6)
Therapies for genetic disorders caused by mutated mitochondrial DNA are an unmet need, in large part due barriers in delivering DNA to the organelle and the absence of relevant animal models. We injected into mouse eyes a mitochondrially targeted Ade
Autor:
Chou, Tsung-Han1 (AUTHOR) tchou@med.miami.edu, Hao, Zixuan1 (AUTHOR), Alba, Diego1 (AUTHOR), Lazo, Angelina1 (AUTHOR), Gallo Afflitto, Gabriele1 (AUTHOR), Eastwood, Jeremy D.1 (AUTHOR), Porciatti, Vittorio1 (AUTHOR) vporciatti@med.miami.edu, Guy, John1 (AUTHOR), Yu, Hong1 (AUTHOR) vporciatti@med.miami.edu
Publikováno v:
International Journal of Molecular Sciences. Dec2023, Vol. 24 Issue 23, p17068. 14p.
Publikováno v:
Gene Therapy Weekly; 12/25/2023, p2733-2733, 1p