Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jeremy D. Baker"'
Autor:
Marangelie Criado-Marrero, Niat T. Gebru, Danielle M. Blazier, Lauren A. Gould, Jeremy D. Baker, David Beaulieu-Abdelahad, Laura J. Blair
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-16 (2021)
Abstract The microtubule associated protein tau is an intrinsically disordered phosphoprotein that accumulates under pathological conditions leading to formation of neurofibrillary tangles, a hallmark of Alzheimer’s disease (AD). The mechanisms tha
Externí odkaz:
https://doaj.org/article/96db6774e5134960a85eb9d69ac1073a
Autor:
Filippo Favretto, David Flores, Jeremy D. Baker, Timo Strohäker, Loren B. Andreas, Laura J. Blair, Stefan Becker, Markus Zweckstetter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Cyclophilin A (CypA) is a peptidylprolyl isomerase that also has chaperone activity and interacts with the intrinsically disordered protein α-Synuclein (aSyn). Here, the authors combine NMR measurements and biochemical experiments to characterise th
Externí odkaz:
https://doaj.org/article/f754601d5f914b7aaa2c4a5fef0fc9ba
Autor:
Leslie A. Sandusky-Beltran, Andrii Kovalenko, Chao Ma, John Ivan T. Calahatian, Devon S. Placides, Mallory D. Watler, Jerry B. Hunt, April L. Darling, Jeremy D. Baker, Laura J. Blair, Mackenzie D. Martin, Sarah N. Fontaine, Chad A. Dickey, April L. Lussier, Edwin J. Weeber, Maj-Linda B. Selenica, Kevin R. Nash, Marcia N. Gordon, Dave Morgan, Daniel C. Lee
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-24 (2019)
Abstract Background Tau stabilizes microtubules; however, in Alzheimer’s disease (AD) and tauopathies, tau becomes hyperphosphorylated, aggregates, and results in neuronal death. Our group recently uncovered a unique interaction between polyamine m
Externí odkaz:
https://doaj.org/article/f6fdfce93d6549e184299e4d7d512e9b
Autor:
Javier Oroz, Bliss J. Chang, Piotr Wysoczanski, Chung-Tien Lee, Ángel Pérez-Lara, Pijush Chakraborty, Romina V. Hofele, Jeremy D. Baker, Laura J. Blair, Jacek Biernat, Henning Urlaub, Eckhard Mandelkow, Chad A. Dickey, Markus Zweckstetter
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The chaperone Hsp90 plays a key role in maintaining cellular homeostasis. Here the authors provide structural insights into substrate recognition and the pro-folding mechanism of Hsp90/co-chaperone complexes by studying the complex of Hsp90 with its
Externí odkaz:
https://doaj.org/article/3a370245b8a44bedbc69cc4763edff90
Correction to: Hsp90 co‑chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild‑type mice
Autor:
Marangelie Criado-Marrero, Niat T. Gebru, Danielle M. Blazier, Lauren A. Gould, Jeremy D. Baker, David Beaulieu-Abdelahad, Laura J. Blair
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-2 (2021)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/46ce15823dae4f4db34d871dcda27a46
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 1, p 79 (2018)
The hypothalamus-pituitary-adrenal (HPA) axis directly controls the stress response. Dysregulation of this neuroendocrine system is a common feature among psychiatric disorders. Steroid hormone receptors, like glucocorticoid receptor (GR), function a
Externí odkaz:
https://doaj.org/article/123beaf70fde4170a83a45b3de04c0e8
Autor:
Pamela McMillan, Sarah J Benbow, Rikki Uhrich, Misa Baum, Timothy J Strovas, Jeremy D Baker, Brian C Kraemer
Publikováno v:
Alzheimer's & Dementia. 18
Publikováno v:
SLAS Discov
Tauopathies are neurological disorders characterized by intracellular tau deposits forming neurofibrillary tangles, neuropil threads, or other disease-specific aggregates composed of the protein tau. Tauopathy disorders include frontotemporal lobar d
Targeting Pathological Tau by Small Molecule Inhibition of the Poly(A):MSUT2 RNA–Protein Interaction
Publikováno v:
ACS Chem Neurosci
Neurofibrillary tangles composed of aberrantly aggregating tau protein are a hallmark of Alzheimer’s disease and related dementia disorders. Recent work has shown that mammalian suppressor of tauopathy 2 (MSUT2), also named ZC3H14 (Zinc Finger CCCH
Autor:
Laura J. Blair, Loren B. Andreas, Jeremy D. Baker, Markus Zweckstetter, Timo Strohäker, Filippo Favretto, Stefan Becker
Publikováno v:
Angewandte Chemie (International Ed. in English)
Angewandte Chemie / International edition 59(14), 5643-5646 (2020). doi:10.1002/anie.201914878
Angewandte Chemie / International edition 59(14), 5643-5646 (2020). doi:10.1002/anie.201914878
Peptidylprolyl isomerases (PPIases) catalyze cis/trans isomerization of prolines. The PPIase CypA colocalizes with the Parkinson's disease (PD)‐associated protein α‐synuclein in cells and interacts with α‐synuclein oligomers. Herein, we descr