Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Jeremy D. Baker"'
Autor:
Marangelie Criado-Marrero, Niat T. Gebru, Danielle M. Blazier, Lauren A. Gould, Jeremy D. Baker, David Beaulieu-Abdelahad, Laura J. Blair
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-16 (2021)
Abstract The microtubule associated protein tau is an intrinsically disordered phosphoprotein that accumulates under pathological conditions leading to formation of neurofibrillary tangles, a hallmark of Alzheimer’s disease (AD). The mechanisms tha
Externí odkaz:
https://doaj.org/article/96db6774e5134960a85eb9d69ac1073a
Autor:
Filippo Favretto, David Flores, Jeremy D. Baker, Timo Strohäker, Loren B. Andreas, Laura J. Blair, Stefan Becker, Markus Zweckstetter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Cyclophilin A (CypA) is a peptidylprolyl isomerase that also has chaperone activity and interacts with the intrinsically disordered protein α-Synuclein (aSyn). Here, the authors combine NMR measurements and biochemical experiments to characterise th
Externí odkaz:
https://doaj.org/article/f754601d5f914b7aaa2c4a5fef0fc9ba
Autor:
Leslie A. Sandusky-Beltran, Andrii Kovalenko, Chao Ma, John Ivan T. Calahatian, Devon S. Placides, Mallory D. Watler, Jerry B. Hunt, April L. Darling, Jeremy D. Baker, Laura J. Blair, Mackenzie D. Martin, Sarah N. Fontaine, Chad A. Dickey, April L. Lussier, Edwin J. Weeber, Maj-Linda B. Selenica, Kevin R. Nash, Marcia N. Gordon, Dave Morgan, Daniel C. Lee
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-24 (2019)
Abstract Background Tau stabilizes microtubules; however, in Alzheimer’s disease (AD) and tauopathies, tau becomes hyperphosphorylated, aggregates, and results in neuronal death. Our group recently uncovered a unique interaction between polyamine m
Externí odkaz:
https://doaj.org/article/f6fdfce93d6549e184299e4d7d512e9b
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0245962 (2021)
Effective SARS-CoV-2 antiviral drugs are desperately needed. The SARS-CoV-2 main protease (Mpro) appears as an attractive target for drug development. We show that the existing pharmacopeia contains many drugs with potential for therapeutic repurposi
Externí odkaz:
https://doaj.org/article/895a0ece70cf42ddbee160139b5c757c
Autor:
Javier Oroz, Bliss J. Chang, Piotr Wysoczanski, Chung-Tien Lee, Ángel Pérez-Lara, Pijush Chakraborty, Romina V. Hofele, Jeremy D. Baker, Laura J. Blair, Jacek Biernat, Henning Urlaub, Eckhard Mandelkow, Chad A. Dickey, Markus Zweckstetter
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The chaperone Hsp90 plays a key role in maintaining cellular homeostasis. Here the authors provide structural insights into substrate recognition and the pro-folding mechanism of Hsp90/co-chaperone complexes by studying the complex of Hsp90 with its
Externí odkaz:
https://doaj.org/article/3a370245b8a44bedbc69cc4763edff90
Correction to: Hsp90 co‑chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild‑type mice
Autor:
Marangelie Criado-Marrero, Niat T. Gebru, Danielle M. Blazier, Lauren A. Gould, Jeremy D. Baker, David Beaulieu-Abdelahad, Laura J. Blair
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-2 (2021)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/46ce15823dae4f4db34d871dcda27a46
Autor:
Pamela McMillan, Sarah J Benbow, Rikki Uhrich, Misa Baum, Timothy J Strovas, Jeremy D Baker, Brian C Kraemer
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f7d1ed7d36f996fa667d21a501c9aef
https://doi.org/10.1002/alz.065960
https://doi.org/10.1002/alz.065960
Autor:
Jeremy D Baker, Lindsey B Shelton, Dali Zheng, Filippo Favretto, Bryce A Nordhues, April Darling, Leia E Sullivan, Zheying Sun, Parth K Solanki, Mackenzie D Martin, Amirthaa Suntharalingam, Jonathan J Sabbagh, Stefan Becker, Eckhard Mandelkow, Vladimir N Uversky, Markus Zweckstetter, Chad A Dickey, John Koren, Laura J Blair
Publikováno v:
PLoS Biology, Vol 15, Iss 6, p e2001336 (2017)
The accumulation of amyloidogenic proteins is a pathological hallmark of neurodegenerative disorders. The aberrant accumulation of the microtubule associating protein tau (MAPT, tau) into toxic oligomers and amyloid deposits is a primary pathology in
Externí odkaz:
https://doaj.org/article/b8e1004e37a14f80868d70e4b48f50e7
Publikováno v:
SLAS Discov
Tauopathies are neurological disorders characterized by intracellular tau deposits forming neurofibrillary tangles, neuropil threads, or other disease-specific aggregates composed of the protein tau. Tauopathy disorders include frontotemporal lobar d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7834495d39d519e418512dbecfeea84
https://doi.org/10.1177/2472555220958387
https://doi.org/10.1177/2472555220958387
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 1, p 79 (2018)
The hypothalamus-pituitary-adrenal (HPA) axis directly controls the stress response. Dysregulation of this neuroendocrine system is a common feature among psychiatric disorders. Steroid hormone receptors, like glucocorticoid receptor (GR), function a
Externí odkaz:
https://doaj.org/article/123beaf70fde4170a83a45b3de04c0e8